This document provides an overview of herbal excipients and novel herbal drug delivery systems. It discusses liposomes, phytosomes, and niosomes as delivery mechanisms that can increase the bioavailability of herbal compounds. Herbal excipients are classified and their advantages as natural, biocompatible carriers are outlined. Applications for treating conditions like diabetes and cardiovascular disease are mentioned. In conclusion, novel herbal drug delivery systems are said to increase the therapeutic value of herbs by reducing toxicity and boosting bioavailability compared to conventional methods.

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2. Course structure and contents for
PRACTICE SCHOOL (BP706PS)
B Pharm Final Year (SEM VII)
DOMAIN-14
NOVEL HERBAL DRUG DELIVERY SYSTEM
HERBAL EXCIPIENTS
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3. A Review Article By:
Roshani Ravindra Jaiswal
Final Year B Pharmacy
(2052811823017)
Guided By:
Prof. Unmesh Bhamare
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4. DOMAIN - NOVEL HERBAL DRUG DELIVERY SYSTEM
TOPIC NAME- HERBAL EXCIPIENTS
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5. INDEX-
• ABSTRACT
• INTRODUCTION
• APPROACHES
• HERBAL EXCIPIENTS
• APPLICATION
• TARGET
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6. ABSTRACT-
The kind of novel herbal formulations such as liposomes, phytosomes,
microsphere ,and ethosomes has been reported using proactive and plant
selections. The novel formulations are described to have remarkable
Phytosome is a patent technology developed by a leading maker of drugs
and nutraceuticals, to incorporate standardized plant extracts or
water-soluble phytoconstituents into phospholipids
to produce lipid-compatible molecular complexes.
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7. INTRODUCTION-
.Necessity of NDDS in herbal drug-
Novel Drug delivery System (NDDS) refers to the approaches, formulations,
technologies, and systems for transporting a pharmaceutical compound in the
body as needed to safely achieve its desired therapeutic effects.
If the novel drug delivery technology is applied in herbal medicine, it may help in
increasing the efficacy and reducing the side effects of various herbal compounds
and herbs.
This is the basic idea behind incorporating novel method of drug delivery in herbal
medicines.
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8. .Physiochemical properties of herbal drug-
. Solubility
. Partition coefficient
. Dissociation constant
. Surface activity
. Protein binding
. Complexation
. Ionisation of dug
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9. .Biological properties of herbal drug-
.Antimicrobial
.Anti-inflammatory
.Antioxidant
.Antiviral
.Antitumor
.Antimalarial
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10. . Advantages of NDDS in herbal drug –
.Enhancement of solubility
.Increase bioavailability
.Protection from toxicity
.Enhancement of stability
.Enhancement of pharmacological activity
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11. .Disadvantages of NDDS in herbal drug-
.Physical handling
.Limited drug loading
.Toxic metabolites may form
.Reduce potential for dose adjustments
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12. Different types of novel herbal formulation currently available
in the market-
. Liposomes, phytosomes, niosomes these are microparticulate or colloidal
carriers, usually 0.05–5.0 μm in diameter which forms , spontaneously
when certain lipids are hydrated in aqueous media. The liposomes are
spherical particles that encapsulate a fraction of the solvent, in which they
freely pass around or float into their interior.
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13. .Liposomes-
These are micro particulate or colloidal carriers, usually 0.05–5.0
μm in diameter which forms spontaneously when certain lipids
are hydrated in aqueous media. The liposomes are
spherical particles that encapsulate a fraction of the solvent in
which they freely pass arounder float into their interior.
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15. Liposomes-
• Advantages-
• Increase of efficacy and therapeutic index of
drug
• Increase of drug/molecules stability
• Non
toxic,flexible,biocompatibility,biodegradable.
• Improve pharmacokinetic effect
• LIMITS-
• Low solubility
• Short half life
• Possibilities of phospholipid oxidation
• Leakage and fusion of encapsulated drug
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16. .Phytosomes –
Most of the bioactive constituents of phytomedicines are flavonoids, which are
poorly bioavailable when taken orally.
Water-soluble phytoconstituent molecules (mainly polyphenols) can be converted
into lipid-compatible molecular complexes, which are called phytosomes.
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17. Phytosomes-
• Advantages-
• Better bioavailability
• Reduced dose
• Better stability
• Greater therapeutic benefit
• LIMIT-
• Limit for Orally or topically
bioavailability
• Phytoconstituents is quickly
eliminated
• Stability problem
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18. Niosomes-
Niosomes are vesicles formed from non ionic surfactants of the
alkyl or di alkyl polyglycerol ether class and cholesterol. niosomes have properties as
potential drug carriers similar to liposomes. Niosomes are different from liposomes
in that they offer certain advantages over liposomes.
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19. Niosomes-
• Advantages-
• Control and targeted drug delivery
• Stable and active
• Increase dermal penetration
• Improve therapeutic performance of
drug
• LIMIT-
• May exhibit fusion of entrapped drug
limits shelf life
• Insufficient drug loading capacity
• Specialized equipment required for
manufacture
• aggregation
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20. HERBAL EXCIPIENT-
.Introduction of excipient-
Excipients are any component other than the active substance(s) intentionally added
to formulation of a dosage form. The herbal excipients which are used in
conventional dosage forms as well as novel drug delivery systems.
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21. Classification of herbal excipient-
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22. Advantages of herbal excipients-
Natural excipients are biocompatibility, economic, easily
available, less toxic, have soothing action and non-irritant,
safe and biodegradable can be chemically modified.
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23. Disadvantages of herbal excipients-
They are microbial contamination, yield and
chemical composition of natural excipients vary in
different conditions.
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24. Application of herbal excipients-
. Specialty excipients are used to produce dosage forms that
can reduce the number of doses.
. By modifying the rate of drug release or improve drug delivery.
. By targeting drug release in a specific region in the gastrointestinal
tract where drug absorption is the highest
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25. Application Of Novel Herbal Drug Delivery system
• DIABETES-
Diabetes mellitus has been emerged as an epidemic worldwide in the
last few decades and proclaimed as fifth cause of death in most
developed countries.
Diabetes mellitus is a chronic hyperglycemic condition which is
described as a metabolic disorder of multiple etiologies characterised
by improper carbohydrate fat and protein metabolism
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26. Cardiovascular Disorder-
Cardiovascular disease are class of disease that involve
the heart or blood vessels.
Cardiovascular disease included coronary artery disease such
as angina myocardial infraction ,heart failure, heart muscle disease.
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27. Targeted herbal drug delivery system-
Plant product have been used since in ancient times for
various purpose. NDDS is also beneficial in comparison to
convential methods for cancer treatment. NDDS include various
novel carriers like liposomes, phytosomes, niosomes etc.
It has modified the herbal drugs to increase their reduce toxicity,
therapeutic value, improve solubility, bioavailability and increase
patient compliance.
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28. CONCLUSION-
In this article we overview Novel Herbal medications have been widely employed all over
the since ancient times and have been acknowledged by doctors and patients for their
better therapeutic value as they cause fewer adverse effects as compared with modern
medications. NDDS not only reduce the repeated administration to overcome
noncompliance, but also help to increase the therapeutic value by reducing toxicity and
increasing the bioavailability.
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29. REFERENCE-
1.Medina OP, Zhu Y, Kairemo K. Targeted liposomal drug delivery in
cancer. Curr Pharm Des 2004;10:2981-9.
2. Mandal SC, Mandal M. Current status and future prospects of new drug
delivery system. Pharm Times 2010;42:13-6.
3. Ajazuddin SS. Applications of novel drug delivery system for herbal
formulations. Fitoterapia 2010;81:680-9.
4. Goyal A, Kumar S, Nagpal M, Singh I, Arora S. Potential of novel
drug delivery systems for herbal drugs. Indian J Pharm Educ Res
2011;45:225-35.
5. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols:
Food sources and bioavailability. Am J Clin Nutr 2004;79:727-47.
6. Chauhan NS, Rajan G, Gopalakrishna B. Phytosomes: A potential
phyto-phospholipid carriers for herbal drug delivery. J Pharm Res
2009;2:1267-70.
7. Parakh SR, Gothoskar AV. Review of mouth dissolving tablet
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30. THANK YOU
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