This document discusses several non-neoplastic breast conditions including inflammations like acute mastitis, granulomatous mastitis, mammary duct ectasia, fat necrosis, and galactocele. It also covers fibrocystic changes including proliferative conditions like epithelial hyperplasia and sclerosing adenosis. Gynecomastia in males is also mentioned. Histopathology images are provided to illustrate duct ectasia, epithelial hyperplasia, apocrine cysts, and intraductal papilloma.
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Benign growths in the uterus that can develop during a woman's childbearing years.Highest incidence was seen in Pakistani women 78%, then rural Indian women 37.65%, urban India 24% and Nigerian women 30%. Arobosoba from Nigeria has reported prevalence of uterine fibroids in black women was more (26%), in comparison to Caucasian women (17.9%).
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
7. NON-NEOPLASTIC CONDITIONS
INFLAMMATIONS
ACUTE MASTITIS AND BREAST ABSCESS
• Acute pyogenic infection of the breast occurs chiefly during the
first few weeks of lactation.
• Bacteria such as staphylococci and streptococci.
• Initially a localised area of acute inflammation
• may cause single or multiple breast abscesses.
• Extensive necrosis and replacement by fibrous scarring
9. Squamous Metaplasia of
Lactiferous Ducts
• Squamous metaplasia of lactiferous ducts is known by a variety of
names, including recurrent subareolar abscess, periductal mastitis, and
Zuska disease.
• Women, and sometimes men, present with a painful erythematous
subareolar mass that clinically appears to be a bacterial abscess.
• In recurrent cases, a characteristic fistula tract often tunnels under the
smooth muscle of the nipple and opens onto the areola.
• The key feature is keratinizing squamous metaplasia of the nipple ducts
10.
11. INFLAMMATIONS
MAMMARY DUCT ECTASIA
(PLASMA CELL MASTITIS)
• Duct ectasia presents as a palpable periareolar mass
• often associated with thick, white nipple secretions and occasionally
with skin retraction.
• Pain and erythema are uncommon.
• This disorder tends to occur in the fifth or sixth decade of life,
• usually in multiparous women.
12. • Patients present with a poorly defined palpable
periareolar mass, sometimes with skin retraction, often
accompanied by thick, white nipple secretions.
• This lesion is characterized chiefly by dilation of ducts,
inspissation of breast secretions, and a marked
periductal and interstitial chronic granulomatous
inflammatory reaction
13. Duct ectasia
Chronic inflammation and fibrosis surround an ectatic duct filled
with inspissated debris.
The fibrotic response can produce a firm irregular mass that mimics
invasive carcinoma on palpation or mammogram.
14. FAT NECROSIS
• generally initiated by trauma.
• The condition presents as a well-defined mass with indurated
appearance.
15. GALACTOCELE
• A galactocele is cystic dilatation of one or more ducts occurring during
lactation.
• ]
• The mammary duct is obstructed and dilated to form a thin-walled cyst
filled with milky fluid.
• Rarely, the wall of galactocele may get secondarily infected.
16. FIBROCYSTIC CHANGE
• Fibrocystic change is the most common benign breast condition
• Its incidence has been reported to range from 10-20% in adult women,
• most often between 3rd and 5th decades of life,
• dramatic decline in its incidence after menopause suggesting the role of
oestrogen in its pathogenesis.
• fibrocystic change of the female breast is characterised by :
• i) Cystic dilatation of terminal ducts.
• ii) Relative increase in inter- and intralobular fibrous tissue.
• iii) Variable degree of epithelial proliferation in the terminal ducts
17. FIBROCYSTIC CHANGE
A. NONPROLIFERATIVE FIBROCYSTIC CHANGES:
SIMPLE FIBROCYSTIC CHANGE
• Simple fibrocystic change most commonly includes 2 features—
formation of cysts of varying size, and increase in fibrous stroma.
• Cysts are formed by dilatation of obstructed collecting ducts,
• obstruction being caused by periductal fibrosis following inflammation
or fibrous overgrowth from oestrogen stimulation.
18. Simple fibrocystic change.
A, Diagrammatic view. It shows cystic dilatation of ducts and increase
in fibrous stroma. There is mild epithelial hyperplasia in terminal
ducts.
B, Non-proliferative fibrocystic changes—fibrosis, cyst formation,
19. FIBROCYSTIC CHANGE
B. PROLIFERATIVE FIBROCYSTIC CHANGES: EPITHELIAL
HYPERPLASIA AND SCLEROSING ADENOSIS
• Proliferative fibrocystic change in the breasts includes 2 entities:
• epithelial hyperplasia
• sclerosing adenosis.
20. FIBROCYSTIC CHANGE
B. PROLIFERATIVE FIBROCYSTIC CHANGES: EPITHELIAL
HYPERPLASIA AND SCLEROSING ADENOSIS
Epithelial hyperplasia
• epitheliosis is defined as increase in the layers of epithelial cells over
the basement membrane to three or more layers in the ducts
(ductal hyperplasia) or lobules (lobular hyperplasia).
21. FIBROCYSTIC CHANGE
B. PROLIFERATIVE FIBROCYSTIC CHANGES: EPITHELIAL
HYPERPLASIA AND SCLEROSING ADENOSIS
sclerosing adenosis
• Sclerosing adenosis is benign proliferation of small ductules or acini
and intralobular fibrosis.
23. A, A normal duct or acinus with a single basally located
myoepithelial cell layer (cells with dark, compact nuclei and scant
cytoplasm) and a single luminal cell layer (cells with larger open
nuclei, small nucleoli, and more abundant cytoplasm).
B, Epithelial hyperplasia. The lumen is filled by a heterogeneous,
mixed population of luminal and myoepithelial cell types. Irregular
slitlike fenestrations are prominent at the periphery
24. GYNAECOMASTIA
(HYPERTROPHY OF MALE BREAST)
• Unilateral or bilateral enlargement of the male breast is known as
gynaecomastia.
• Since the male breast does not contain secretory lobules, the
enlargement is mainly due to proliferation of ducts and increased
periductal stroma.
• Gynaecomastia occurs in response to hormonal stimulation, mainly
oestrogen.
25.
26.
27. Apocrine cysts
A, Clustered, rounded
calcifications are seen in a
specimen radiograph.
B, Gross appearance of
typical cysts filled with dark,
turbid fluid contents.
C, Cysts are lined by
apocrine cells with round
nuclei and abundant
granular cytoplasm. Note the
luminal calcifications.