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Non-Invasive Cholesterol
Measurement
Goverdhan. R
Introduction:
• Heart Attack and stroke account for 30% of total death due to
diseases[1]. Death
Heart Attack and stroke Various Diseases
Courtesy :WHO
Factors that leads to Vascular Diseases:
• Blood pressure
• Weight
• Exercise level
• Diabetes
• Cholesterol level
Most of these factors have easy or readily available ways to measure
and keep track such as weight balances, glucose meters, apps to track
of exercise.
Why Non-Invasive cholesterol measurement?
• Cholesterol is the hardest to keep track of and thus the least
monitored.
• Currently the only solution to keep track of cholesterol is to get
blood analysis done at the hospitals which is not only inconvenient
and expensive but require blood samples.
Thus it critical to have a non or less invasive cholesterol monitor to
check cholesterol as often as necessary.
Cholesterol
Basics, CAD, Score
Cholesterol score[2]:
Total cholesterol
Less than 200 mg/dL: desirable
200-239 mg/dL: borderline high risk
240 and over: high risk
HDL (high density lipoprotein)
Less than 40 mg/dL (men), less than 50
mg/dL (women): increased risk of heart
disease
Greater than 60mg/dL: some protection
against heart disease
LDL (low density lipoprotein)
Less than 100 mg/dL: optimal
100-129 mg/dL: near optimal/above
optimal
130-159 mg/dL: borderline high
160- 189 mg/dL: high
190 mg/dL and above: very high
Triglycerides
Less than n150 mg/dL: normal
150-199 mg/dL: borderline to high
200-499mg/dL: high
Above 500 mg/dL: very high
Relation between ECG and cholesterol:
• In patients after a myocardial infarction, there is an ST segment
elevation that correlates to higher blood LDL or total cholesterol[3].
• ST segment resolution 30 minutes after successful angioplasty of IRA
was observed in 116 patients (77%), who were classified as group A,
whereas 34 (23%) presented ECG signs of no-reflow (group B).
• Cholesterol increases the open probability of cardiac KACh currents[4].
Relation between Cardiac Membrane
potential and ECG[5].
References
[1] Dr. Judith MacKay, Dr. George A. Mensah “The Atlas of Heart Disease and Stroke”, World health
organization.
[2] Benjamin Wedro, William C. Shiel Jr, “Cholesterol chart”, http://www.emedicinehealth.com/,
web.
[3] S et al. Dobrzycki, "High Cholesterol in Patients with ECG signs of No-Reflow after Myocardial
Infarction," Rocz Akad Med Bialymst, pp. 118-122.
[4] Anna N. Bukiya, et al. “Chlesterol increases the open probability of cardiac KACh currents” ,
BBAMEM, 2015, pp 2406 – 2413.
[5] Birnbaum SG, Varga AW, Yuan LL, et al. Structure and function of Kv4-family transient potassium
channels. Physiol Rev 2004;84:803-833.

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Non invasive cholesterol measurement- Study

  • 2. Introduction: • Heart Attack and stroke account for 30% of total death due to diseases[1]. Death Heart Attack and stroke Various Diseases
  • 4. Factors that leads to Vascular Diseases: • Blood pressure • Weight • Exercise level • Diabetes • Cholesterol level Most of these factors have easy or readily available ways to measure and keep track such as weight balances, glucose meters, apps to track of exercise.
  • 5. Why Non-Invasive cholesterol measurement? • Cholesterol is the hardest to keep track of and thus the least monitored. • Currently the only solution to keep track of cholesterol is to get blood analysis done at the hospitals which is not only inconvenient and expensive but require blood samples. Thus it critical to have a non or less invasive cholesterol monitor to check cholesterol as often as necessary.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11. Cholesterol score[2]: Total cholesterol Less than 200 mg/dL: desirable 200-239 mg/dL: borderline high risk 240 and over: high risk HDL (high density lipoprotein) Less than 40 mg/dL (men), less than 50 mg/dL (women): increased risk of heart disease Greater than 60mg/dL: some protection against heart disease LDL (low density lipoprotein) Less than 100 mg/dL: optimal 100-129 mg/dL: near optimal/above optimal 130-159 mg/dL: borderline high 160- 189 mg/dL: high 190 mg/dL and above: very high Triglycerides Less than n150 mg/dL: normal 150-199 mg/dL: borderline to high 200-499mg/dL: high Above 500 mg/dL: very high
  • 12. Relation between ECG and cholesterol: • In patients after a myocardial infarction, there is an ST segment elevation that correlates to higher blood LDL or total cholesterol[3]. • ST segment resolution 30 minutes after successful angioplasty of IRA was observed in 116 patients (77%), who were classified as group A, whereas 34 (23%) presented ECG signs of no-reflow (group B). • Cholesterol increases the open probability of cardiac KACh currents[4].
  • 13.
  • 14. Relation between Cardiac Membrane potential and ECG[5].
  • 15. References [1] Dr. Judith MacKay, Dr. George A. Mensah “The Atlas of Heart Disease and Stroke”, World health organization. [2] Benjamin Wedro, William C. Shiel Jr, “Cholesterol chart”, http://www.emedicinehealth.com/, web. [3] S et al. Dobrzycki, "High Cholesterol in Patients with ECG signs of No-Reflow after Myocardial Infarction," Rocz Akad Med Bialymst, pp. 118-122. [4] Anna N. Bukiya, et al. “Chlesterol increases the open probability of cardiac KACh currents” , BBAMEM, 2015, pp 2406 – 2413. [5] Birnbaum SG, Varga AW, Yuan LL, et al. Structure and function of Kv4-family transient potassium channels. Physiol Rev 2004;84:803-833.