This document discusses the effects of drug abuse on both individuals and society. It explains how drugs disrupt the brain's reward system, leading to tolerance and addiction. As drug abuse continues, the brain adapts by producing less dopamine, reducing pleasure from both drugs and other activities. This compels the addict to take larger drug amounts. The document also notes the economic costs of drug abuse and health issues like HIV/AIDS that can result from injection drug use. Over 500,000 Americans die each year due to drug abuse and its consequences.