Uploaded byCairo university
Neurophysiology
The document summarizes the process of an action potential in a neuron. It discusses how: 1) In the resting state, sodium ions are concentrated outside the cell and potassium ions inside, creating a negative charge inside. 2) A stimulus causes sodium gates to open, allowing sodium ions to rush inside and depolarize the cell. 3) As the cell reaches threshold, an action potential is generated and propagates along the membrane as sodium gates open down the axon. 4) The sodium gates then close and potassium gates open, pumping ions out to repolarize the cell back to its resting potential.
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Neurophysiology
- 1.
- 2. Human cell Cell membraneconsists of phospholipids. The lipid bilayer permits passage of fat soluble substances. Other substances enter the cell through protein gates which propagates along the cell membrane. 2
- 3. Sodium ions inhigh concentration outside the cell. 3
- 4. Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state In resting state of cell membrane the sodium molecules concentrated outside of the cell membrane, while potassium concentrates inside the cell . With resultant Relative negative charges created inside the cell membrane while positive charges detected outside. 4 -70mv State of polarization 0
- 5. 5 Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state
- 6. 5 Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state
- 7. 5 Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state
- 8. 6 Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state
- 9. 7 When gates opena flow of sodium ions go through gates until equilibrium between concentration outside and inside the cell. Na Na Na K Stimulus Opening of sodium gates Influx of Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state
- 10. 7 When gates opena flow of sodium ions go through gates until equilibrium between concentration outside and inside the cell. Na Na Na K Stimulus Opening of sodium gates Influx of Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state
- 11. 7 When gates opena flow of sodium ions go through gates until equilibrium between concentration outside and inside the cell. Na Na Na K Stimulus Opening of sodium gates Influx of Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state
- 12. 8 -70mv +40mv Depolarization Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state 0
- 13. 9 Na Na Na K When gates opena flow of sodium ions go through gates until equilibrium between concentration outside and inside the cell. Na Na Na Stimulus Opening of sodium gates Influx of Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state
- 14. 10 Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state -70mv +40mv Depolarization Action potential 0
- 15. 11 Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state Propagation of action potential
- 16. Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state Repolarization Na Na Na Na Na Na Aden osine Ph Ph Ph Outside Inside Repolarization Sodium pump 12 0
- 17. Stimulus Opening of sodium gates Influxof Na ions from outside to inside cell Action potential Depolarization Propagation Repolarization Resting state Resting state Repolarization Na Na Na Na Na Na Aden osine Outside Inside Repolarization Sodium pump 12 0
- 18. 18 To prevent theaction potential. The influx of sodium ion through the gates should be prohibited. The membrane gates should be closed through Pharmacological Action of local anesthetic agents. Local Pain control