AutoRE is a software developed by Microsoft to detect spam emails generated by botnets. It combines content-based and non-content-based detection methods. It first pre-processes URLs from emails, groups similar URLs into domains, and generates domain-agnostic regular expressions to identify patterns. This allows it to detect botnets even if they change domains. AutoRE's analysis of botnet characteristics informed future related work on real-time reputation systems and large-scale botnet detection using behavior analysis and IP address distribution. However, AutoRE itself was not fully implemented in real-time.