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Nerve Fibers
K Krupa Sagar
Dept. of Pharmacology
Neuron
Nerve Fiber
1.Depending on the Structure
Myelin sheath
2.Depending on Distribution
Somatic nerve fibers
• These are α type motor nerve fibers.
• The neurotransmitter released at the neuron endings is
acetylcholine(Ach).
• It always leads to muscles excitation . Inhibition takes place
centrally due to participation of interneurons.
Autonomic nerve fibers
• They innervate smooth muscles , cardiac muscles
and Glands.
• Their main work is to maintain homeostasis with the
help of autonomic nervous system.
• They can lead to either excitation or inhibition of
Effector organs.
Properties of Nerve Fiber
Important Properties
• Excitability
• Conductivity
• Unfatigability
• Refractive period
• All or none response
• Summation
• Accommodation
Excitability:
• nerve fibres are highly excitable tissue
• respond to various stimuli
• Capable of generating electrical impulse
Conductivity:
• action potential is generated in the nerve fibre,
which is propagated along its entire length to the
axon terminal.
Refractive period:
• during action potential the excitability of a nerve
become reduced
• that is a new impulse cannot be generated during a
Action Potential
• Types:
a. Absolute refractory period (ARP)
b. Relative refractory period( RRP)
Unfatiguability :
• Nerve fibres can not be fatigued even when they are
stimulated continuously.
All or none response:
• Either all of the action potential is seen or none at all
• If a stimulus of threshold strength is applied action
Potential will be generated
• Further increase in strength of stimulus or duration
has no effect on amplitude of action Potential
• But can affect frequency
Summation:
• Application of a sub threshold stimulus does not
evoke an action potential. However if sub threshold
stimuli are applied in rapid succession they are
added and they produce an action potential.
Accommodation:
• Application of continuous stimuli may decrease the
excitability of nerve fibre.
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
nervefibers-210720082756.pdf
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nervefibers-210720082756.pdf

  • 1. Nerve Fibers K Krupa Sagar Dept. of Pharmacology
  • 3.
  • 4.
  • 6.
  • 7.
  • 8.
  • 9. 1.Depending on the Structure
  • 10.
  • 12.
  • 14. Somatic nerve fibers • These are α type motor nerve fibers. • The neurotransmitter released at the neuron endings is acetylcholine(Ach). • It always leads to muscles excitation . Inhibition takes place centrally due to participation of interneurons.
  • 15. Autonomic nerve fibers • They innervate smooth muscles , cardiac muscles and Glands. • Their main work is to maintain homeostasis with the help of autonomic nervous system. • They can lead to either excitation or inhibition of Effector organs.
  • 17. Important Properties • Excitability • Conductivity • Unfatigability • Refractive period • All or none response • Summation • Accommodation
  • 18. Excitability: • nerve fibres are highly excitable tissue • respond to various stimuli • Capable of generating electrical impulse Conductivity: • action potential is generated in the nerve fibre, which is propagated along its entire length to the axon terminal.
  • 19. Refractive period: • during action potential the excitability of a nerve become reduced • that is a new impulse cannot be generated during a Action Potential • Types: a. Absolute refractory period (ARP) b. Relative refractory period( RRP)
  • 20. Unfatiguability : • Nerve fibres can not be fatigued even when they are stimulated continuously. All or none response: • Either all of the action potential is seen or none at all • If a stimulus of threshold strength is applied action Potential will be generated • Further increase in strength of stimulus or duration has no effect on amplitude of action Potential • But can affect frequency
  • 21. Summation: • Application of a sub threshold stimulus does not evoke an action potential. However if sub threshold stimuli are applied in rapid succession they are added and they produce an action potential. Accommodation: • Application of continuous stimuli may decrease the excitability of nerve fibre.