This document summarizes JDRF's work towards curing, treating, and preventing type 1 diabetes. It discusses JDRF's goals of developing life-changing therapies through research, clinical development, and regulatory work. This includes work towards developing an artificial pancreas through improved glucose sensors and control software. The document also discusses current challenges in treating type 1 diabetes, like increasing rates of hypoglycemia and poor glucose control. JDRF is working on various approaches to cure diabetes through islet and stem cell transplantation, regenerating beta cells, and preventing diabetes onset through vaccines and beta cell survival agents.