This study investigated the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in a tertiary hospital in Benghazi, Libya. The researchers found that 31% of 200 S. aureus isolates from hospitalized patients were MRSA. MRSA prevalence was high across age and sex groups and hospital wards. Most MRSA isolates were from patients with burns or surgical wound infections. Resistance to multiple antibiotics including vancomycin, ciprofloxacin, chloramphenicol and erythromycin was observed in MRSA isolates. The study concludes that MRSA prevalence in Libyan hospitals is high and improved surveillance of antibiotic resistance is needed.
Methicillin-resistant Staphylococcus aureus (MRSA) infections have been recognized for decades as hospital acquired MRSA (HA-MRSA). Nowadays, MRSA is also recognized as a worldwide emerging community-associated pathogen. Community associated- MRSA (CA-MRSA) has been shown to be more virulent with a high degree of severity of disease when compared to HA-MRSA.
Methicillin-resistant Staphylococcus aureus (MRSA) infections have been recognized for decades as hospital acquired MRSA (HA-MRSA). Nowadays, MRSA is also recognized as a worldwide emerging community-associated pathogen. Community associated- MRSA (CA-MRSA) has been shown to be more virulent with a high degree of severity of disease when compared to HA-MRSA.
Evaluation of resistance profile of pseudomonas aeruginosa with reference to ...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Multidrug Resistance Pattern of Staphylococcus Aureus Isolates in Maiduguri M...Scientific Review
Multi drug-resistant (MDR) isolates of Staphylococcus aureus are on rise and are becoming a challenge for timely and appropriate treatment. The present study was carried out with an objective to isolate Staphylococcus aureus from clinical samples and determine their sensitivity. Out of 110 samples collected, 44 were shown to contained S. aureus. The isolates were subjected to antibiotic sensitivity tests using 10 different and commonly used antibiotics by modified Kirby- Bauer disc diffusion technique. Out of the total isolates (42) tested, only 7.1% were susceptible to all the antibiotics. Multiple resistance was eminent in over 92% with highest occurrence in 4.8% where the entire antibiotics were resisted. Multiple antibiotic resistance indixes (MAR index) indicated that 0.6 index occurred most (23.8%) followed by 0.5 (19.0%). On the other hand, 0.1 and 0.8 indexes were the lowest with 0.0% and 1.0% occurrence respectively. Ciprofloxacin was resisted by most of the organisms (64.3%) while amoxicillin (64.3%) and streptomycin (61.9%) were most efficacious. With over 90% isolate having MAR index ≥ 0.2, the multiple drug resistance by the S. aureus is quite alarming and might suggest inappropriate antibiotic usage by the sampled population. Therefore, the need to strategize the nature of antibiotic treatment against S. aureus and massive campaign on indiscriminate antibiotic use is urgent.
Study of Bacterial Isolates and their Susceptibility Pattern in Chronic Suppu...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Incidence rate of multidrug-resistant organisms in a tertiary care hospital, ...Apollo Hospitals
Antimicrobial resistance to microorganisms is a growing public health concern globally, especially in developing countries. This study was conducted to study the incidence rate of multidrug-resistant organisms with their antibiotic sensitivity pattern.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Prevalence and Characterisation of Beta Lactamases in Multi Drug Resistant Gr...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Agile Project Management Part 2 Final V1.5Mia Horrigan
Part two of this presentation looks at case studies where we applied agile as a philosophy and used a Prince2 methodology basis for our zenagile framework
Evaluation of resistance profile of pseudomonas aeruginosa with reference to ...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Multidrug Resistance Pattern of Staphylococcus Aureus Isolates in Maiduguri M...Scientific Review
Multi drug-resistant (MDR) isolates of Staphylococcus aureus are on rise and are becoming a challenge for timely and appropriate treatment. The present study was carried out with an objective to isolate Staphylococcus aureus from clinical samples and determine their sensitivity. Out of 110 samples collected, 44 were shown to contained S. aureus. The isolates were subjected to antibiotic sensitivity tests using 10 different and commonly used antibiotics by modified Kirby- Bauer disc diffusion technique. Out of the total isolates (42) tested, only 7.1% were susceptible to all the antibiotics. Multiple resistance was eminent in over 92% with highest occurrence in 4.8% where the entire antibiotics were resisted. Multiple antibiotic resistance indixes (MAR index) indicated that 0.6 index occurred most (23.8%) followed by 0.5 (19.0%). On the other hand, 0.1 and 0.8 indexes were the lowest with 0.0% and 1.0% occurrence respectively. Ciprofloxacin was resisted by most of the organisms (64.3%) while amoxicillin (64.3%) and streptomycin (61.9%) were most efficacious. With over 90% isolate having MAR index ≥ 0.2, the multiple drug resistance by the S. aureus is quite alarming and might suggest inappropriate antibiotic usage by the sampled population. Therefore, the need to strategize the nature of antibiotic treatment against S. aureus and massive campaign on indiscriminate antibiotic use is urgent.
Study of Bacterial Isolates and their Susceptibility Pattern in Chronic Suppu...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Incidence rate of multidrug-resistant organisms in a tertiary care hospital, ...Apollo Hospitals
Antimicrobial resistance to microorganisms is a growing public health concern globally, especially in developing countries. This study was conducted to study the incidence rate of multidrug-resistant organisms with their antibiotic sensitivity pattern.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Prevalence and Characterisation of Beta Lactamases in Multi Drug Resistant Gr...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Agile Project Management Part 2 Final V1.5Mia Horrigan
Part two of this presentation looks at case studies where we applied agile as a philosophy and used a Prince2 methodology basis for our zenagile framework
Multidrug Resistance Pattern of Staphylococcus Aureus Isolates in Maiduguri ...Scientific Review SR
Multi drug-resistant (MDR) isolates of Staphylococcus aureus are on rise and are becoming a
challenge for timely and appropriate treatment. The present study was carried out with an objective to isolate
Staphylococcus aureus from clinical samples and determine their sensitivity. Out of 110 samples collected, 44
were shown to contained S. aureus. The isolates were subjected to antibiotic sensitivity tests using 10 different
and commonly used antibiotics by modified Kirby- Bauer disc diffusion technique. Out of the total isolates (42)
tested, only 7.1% were susceptible to all the antibiotics. Multiple resistance was eminent in over 92% with
highest occurrence in 4.8% where the entire antibiotics were resisted. Multiple antibiotic resistance indixes
(MAR index) indicated that 0.6 index occurred most (23.8%) followed by 0.5 (19.0%). On the other hand, 0.1
and 0.8 indexes were the lowest with 0.0% and 1.0% occurrence respectively. Ciprofloxacin was resisted by
most of the organisms (64.3%) while amoxicillin (64.3%) and streptomycin (61.9%) were most efficacious. With
over 90% isolate having MAR index ≥ 0.2, the multiple drug resistance by the S. aureus is quite alarming and
might suggest inappropriate antibiotic usage by the sampled population. Therefore, the need to strategize the
nature of antibiotic treatment against S. aureus and massive campaign on indiscriminate antibiotic use is urgent.
Abstract— Methicillin-resistant Staphylococcus aureus (MRSA) poses a great risk to burn patients with potential to cause significant morbidity and mortality. This study aimed to find out the prevalence of MRSA and its susceptibility, in burn wound infection/colonization in a Tertiary Care Hospital in North India. A retrospective study was conducted among patients admitted in burn ward of our hospital, between January to December 2012. All the patients irrespective of age, sex, duration of hospital stay, percentage and degree of burn were included in our study. Wound swabs from 1294 patients hospitalized in burn ward were analysed for bacteriological examination. Swabs were inoculated on Blood agar, MacConkey agar and Brain heart infusion broth. Isolates were examined for colony characteristics, Gram staining and biochemical tests. Antimicrobial susceptibility testing was done by modified Stokes disc diffusion method. Detection of MRSA was done by cefoxitin (30g) disc diffusion method. Among the Staphylococcus aureus (S.aureus) isolates, 56.7% (80/141) were found to be MRSA while 43.3% (61/141) were Methicillin Susceptible S.aureus (MSSA). All the MRSA isolates were resistant to penicillin, cephalexin and cefazolin. Resistance to erythromycin, clindamycin, ofloxacin, ciprofloxacin, gentamicin, amikacin, rifampicin, chloramphenicol was found to be 74%, 97.4%, 96%, 100%, 97.4%, 84.6%, 11.5%, 10.3%. All MRSA isolates were found to be sensitive to vancomycin and teicoplanin while 1.3% were resistant to linezolid. Although survival rates for burn patients have improved substantially over the years, nosocomial infections still remain a major challenge in burn care. This concludes that there is high prevalence of nosocomial infections specially the presence of multidrug resistant bacteria like Methicillin Resistant Staphylococcus aureus among burn patients suggest continuous surveillance of burn wound infections and development and stringent implementation of antibiotic policy.
Ocular inflammatory disease and ocular tuberculosis in a cohort of patients c...Dr.Samsuddin Khan
Abstract
BACKGROUND:
The prevalence and the patterns of ocular inflammatory disease and ocular tuberculosis (TB) are largely undocumented among Multidrug Resistant TB (MDR-TB) patients co-infected with Human Immunodeficiency Virus (HIV) and on antituberculosis and antiretroviral therapy (ART).
METHODS:
Lilavati Hospital and Research Center and Médecins Sans Frontières (MSF) organized a cross-sectional ophthalmological evaluation ofHIV/MDR-TB co-infected patients followed in an MSF-run HIV-clinic in Mumbai, India, which included measuring visual acuity, and slit lamp and dilated fundus examinations.
RESULTS:
Between February and April 2012, 47 HIV/MDR-TB co-infected patients (including three patients with extensively drug-resistant TB) were evaluated. Sixty-four per cent were male, mean age was 39 years (standard deviation: 8.7) and their median (IQR) CD4 count at the time of evaluation was 264 cells/μL (158-361). Thirteen patients (27%) had detectable levels of HIV viremia (>20 copies/ml). Overall, examination of the anterior segments was normal in 45/47 patients (96%). A dilated fundus examination revealed active ocular inflammatory disease in seven eyes of sevenpatients (15.5%, 95% Confidence Intervals (CI); 5.1-25.8%). 'These included five eyes of five patients (10%) with choroidal tubercles, one eye of one patient (2%) with presumed tubercular chorioretinitis and one eye of one patient (2%) with evidence of presumed active CMV retinitis. Presumed ocular tuberculosis was thus seen in a total of six patients (12.7%, 95% CI; 3.2-22.2%). Two patients who had completed anti-TB treatment had active ocular inflammatory disease, in the form of choroidal tubercles (two eyes of two patients). Inactive scars were seen in three eyes of three patients (6%).Patients with extrapulmonary TB and patients<39 years old were at significantly higher risk of having ocular TB [Risk Ratio: 13.65 (95% CI: 2.4-78.5) and 6.38 (95% CI: 1.05-38.8) respectively].
CONCLUSIONS:
Ocular inflammatory disease, mainly ocular tuberculosis, was common in a cohort of HIV/MDR-TB co-infected patients in Mumbai,India. Ophthalmological examination should be routinely considered in HIV patients diagnosed with or suspected to have MDR-TB, especially in those with extrapulmonary TB.
Abstract— Season seems to have its role in wound infection which is the second commonest nosocomial infection and most troublesome disorder of wound healing. This study was carried out on 100 post-operative cases of Surgical Unit 1st of General Surgery Department of Sawai Man Singh Hospital, Jaipur (Rajasthan) India in years 2014. This study aimed to find out the seasonal trend in Post-operative wound infections (PSI). After interview of these, swab from post-operative wound was taken and sent for culture and sensitivity test in Microbiology. Results were inferred by Chi-square test. In this study, post-operative wound infection rate was found 21%. In majority of cases, causative agent found in post-operative infected wound was Staphylococci (90.48%) followed with Streptococci, E. Coli, Klebsella and Pseudomonas. Maximum cases were found in April followed by March, January and none was found in other months but this variation was not found significant.
Introduction: Bloodstream infections (BSIs) are associated with a high mortality rate of 20%-50%. Blood culture is paramount to identify causative agents of BSIs to choose an appropriate antimicrobial therapy. Objectives: The present study was undertaken to analyze the various microorganisms causing BSIs and study their antimicrobial resistance patterns in a tertiary care hospital, Eastern India. Materials and Methods: A total of 239 blood specimens from clinically suspected cases of BSIs were studied for 6 months from July 2015 to December 2015. Blood specimens were incubated in BacT/ALERT ® 3D system (bioMerieux, Durham, NC, USA) a fully automated blood culture system for detection of aerobic growth. Identification and antimicrobial susceptibility testing were conducted on VITEK ® 2 (bioMerieux, Durham, NC, USA) as per Clinical Laboratory Standards Institute guidelines. Results: Out of 239 specimens, 41 (17.2%) yielded growth of different microorganisms. From these isolates, 20 (48.8%) were Gram-negative bacilli, 18 (43.9%) were Gram-positive cocci and rest 3 (7.3%) were yeasts. Among Gram-negative bacilli, Klebsiella pneumoniae sub spp. pneumoniae (70%) was most commonly isolated. Coagulase-negative staphylococci (88.9%) were the most common isolate among Gram-positive cocci. All three Candida spp. isolated were nonalbicans Candida (two Candida tropicalis and one Candida krusei). Gram-negative isolates were least resistant to tigecycline and colistin. All Gram-positive cocci were sensitive to linezolid. Conclusion: Monitoring of data regarding the prevalence of microorganisms and its resistance patterns would help in currently prescribing antimicrobial regimens and improving the infection control practices by formulating policies for empirical antimicrobial therapy.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. Buzaid et al. - MRSA in a Libyan hospital J Infect Dev Ctries 2011; 5(10):723-726
724
strains against various antibiotics used for treating
hospitalized patients in a major tertiary hospital in
Libya.
Methodology
Two hundred non-duplicate S. aureus strains
isolated from clinical specimens of pus from
abscesses, wound swabs, blood, cerebrospinal fluid,
central venous line tips, endotracheal tube tips, and
urine catheter tips were included in the present study.
These isolates were submitted to the Microbiology
Laboratory at Aljala Surgical and Trauma Hospital
(395 beds), Benghazi (population > 650,000
inhabitants), Libya, from April to July 2007.
Patient history was reviewed from hospital
records upon discharge from the hospital; records
included patient's age, sex, ward, cause of admission,
type of sample (i.e., pus, wound swabs, central
venous line tips, endotracheal tube tips, blood
cultures, urine catheter tips, etc.), and risk factors for
MRSA infection, such as diabetes mellitus, burn, skin
and soft tissue infection, chronic orthopedic disease,
surgical wound infection, invasive procedures in the
intensive care unit (ICU), and extremes of age.
Isolates of S. aureus were identified by catalase
and tube coagulase tests. Resistance to methicillin
was determined by the oxacillin disc-diffusion assay
according to the guidelines of the Clinical and
Laboratory Standards Institute (CLSI) [10]. Isolates
of S. aureus resistant to oxacillin were further tested
for production of penicillin binding protein 2a
(PBP2a) using a slide latex agglutination test (Oxoid,
Basingstoke, UK) and for production of green
colonies on chromogenic MRSA ID medium
(bioMériueux, Marcy L'Etoile, France) according to
the manufacturer's instructions. MRSA strains were
further tested for resistance to other antimicrobials
using commercial discs (Oxoid); vancomycin (30
µg), ciprofloxacin (5 µg), erythromycin (15 µg),
chloramphenicol (30 µg) and fusidic acid disc (10
µg); according to the CLSI guidelines in the same
manner used for the oxacillin disc testing. The Epi-
2000 software (Centers for Disease Control and
Prevention, Atlanta, GA, USA) was employed for
statistical analysis. P-values were calculated using
X2
-test and P < 0.05 was considered statistically
significant.
Results
Of the 200 S. aureus examined 62 (31%) were
MRSA. MRSA was detected in 31.8% (28/88) and
30.4% (34/112) of S. aureus from female and male
patients, respectively. In addition, MRSA was found
among 26.8% (11/41), 30.9% (38/123) and 36.1%
(13/36) of S. aureus from patients < 1-19, 20-49 and
> 50 years of age (P > 0.05 for all comparisons),
respectively. MRSA was distributed in most wards of
the hospital but a higher prevalence was noted in the
burns wards, where approximately two-thirds
(68.4%, 13/19) of the patients with S. aureus
infection had MRSA. According to the type of
infection, it was observed in 20.3% (26/128) of S.
aureus from patients with skin and soft tissue
infections in the form of abscesses, cellulitis and
diabetic foot; 54% (27/50) of S. aureus from patients
with surgical wound infection; 40% (6/15) of S.
aureus from patients who underwent invasive
procedures in the ICU; and in 50% (2/4) of S. aureus
from patients with chronic orthopedic disease in the
form of chronic osteomyelitis and septic arthritis.
Based on the disc-diffusion results, the antibiotic
resistance pattern of 62 patients with MRSA was as
follows: vancomycin resistance was observed in 11
(17.7%) cases; ciprofloxacin resistance was observed
in 21 (33.9%) cases; chloramphenicol resistance was
observed in 24 (38.7%) cases; fusidic acid resistance
was observed in 26 (41.9%) cases; and erythromycin
resistance was observed in 29 (46.8%) cases.
Discussion
In the present investigation MRSA was found in
31% of S. aureus isolates examined. Our findings are
in line with previous reports from the Mediterranean
region. Borg et al. [11] reported on the prevalence of
resistance in clinically relevant pathogens within
hospitals in eight southeastern Mediterranean
countries. They observed a median of 43% (range =
10-65%) for MRSA within isolates of S. aureus. It
should be noted that Libya was not included in the
previously mentioned study. However, our findings
support the view that the Mediterranean region
indeed constitutes a high prevalence region for
MRSA [11]. Slightly higher rates than ours for
MRSA were reported from some other countries in
the Middle East. For instance, MRSA was found in
38% (111/292) of S. aureus isolated from clinical
specimens in 1998 at King Abdulaziz University
Hospital, Jeddah, Saudi Arabia [12].
Although an increase in the prevalence of MRSA
was observed to correlate with increased age of
patients, the differences in the prevalence rates of
MRSA among the three age groups examined in the
present study were not statistically significant (P >
0.05). Madani reported that MRSA affected all age
3. Buzaid et al. - MRSA in a Libyan hospital J Infect Dev Ctries 2011; 5(10):723-726
725
groups, but almost half (45.9%) of the patients were
in the “extremes of age” group (< 1 or > 60 years)
[12]. Also, the author observed no preference for any
gender. We have also observed no differences and the
prevalence rates among S. aureus from females and
males were 31.8% and 30.4%, respectively.
MRSA was detected in clinical samples
examined from different wards in the present
investigation; however, the highest prevalence rate of
MRSA was found among S. aureus from patients
with burns (68.4%) and surgical wound infections
(54%). Zorgani et al. [13] reported MRSA in 54.2%
(65/120) of S. aureus isolated from burn patients in
the Burn and Plastic Surgery Center in Tripoli, Libya.
Others have reported similar findings [12,14].
MRSA found in this study were generally
multidrug resistant with increasing resistance to
vancomycin, ciprofloxacin, chloramphenicol, fucidic
acid and erythromycin. This observation is in
agreement with other studies [15-17]. Vancomycin
resistant S. aureus was recorded in a 17% of patients
with MRSA, which could be related to a prolonged
use of vancomycin on one hand and the possibility of
the presence of vancomycin resistant enterococci in
the hospital on the other [3,4].
To our knowledge this study is the first to report
on the prevalence of MRSA in a tertiary hospital in
Libya. The prevalence of MRSA in Aljala Surgical
and Trauma Hospital in Benghazi was high and this
may be the case for other hospitals in Libya. A recent
study that included six different hospitals in Tripoli,
Libya, found that 36.8% of health-care workers were
MRSA positive [18]. To reduce the incidence of
infections due to MRSA and other antimicrobial-
resistant pathogens in Libyan hospitals a sound
surveillance program of nosocomial infections is
urgently needed that include monitoring antibiotic
susceptibility patterns of such pathogens and
establishing wise antibiotic prescription guidelines.
References
1. Brown D, Edwards D, Hawkey P, Morrison D, Ridqway G,
Towner K, Wren M (2005) Guidelines for the laboratory
diagnosis and susceptibility testing of methicillin–resistant
Staphylococcus aureus (MRSA). Antimicrob Agents
Chemother 65: 1000-1018.
2. Jones RN (2008) Key considerations in the treatment of
complicated Staphylococcal infections. Clin Microbiol
Infect 14: 3-9.
3. Peacock S (2006) Staphylococcus aureus. In: Gillespie S
and Hawkey P, editors). Principal and practice of clinical
bacteriology. 2nd
ed. England: John Wiley and Sons ltd, 620
p.
4. Lowy F (2005) Staphylococcal infections. In: Fauci A,
Braunwarld E, Kasper D, Hauser S, Longo D, Jameson J,
editors. Harrison's principles of internal medicine. 16th
ed.
New York: MacGraw-Hill Companies, 2958 p.
5. Kayser FH Staphylococcus aureus. In: Kayser FH, Bienz K
A, Eckert J, Zinkernagel RA, editors. Medical
Microbiology. New York: Thieme Stuttgart, 724 p.
6. Shurland S, Zhan M, Bradham DD, Roghmann MC (2007)
Comparison of mortality risk associated with bacteremia due
to methicillin-resistant and methicillin-susceptible
Staphylococcus aureus. Infect Control Hosp Epidemiol 28:
273-279.
7. Selvey LA, Whitby M, Johnson B (2000) Nosocomial
methicillin-resistant Staphylococcus aureus bacteremia: is it
any worse than nosocomial methicillin-sensitive
Staphylococcus aureus bacteremia? Infect Control Hosp
Epidemiol 21: 645-648.
8. Grundmann H, Aires-de-Sousa M, Boyce J, Tiemersma E
(2006) Emergence and resurgence of methicillin-resistant
Staphylococcus aureus as a public-health threat. Lancet 368:
874-85.
9. El-Bouri KW (2009) Clinical microbiology services are
essential for diagnosis, treatment and prevention of MRSA
and other nosocomial pathogens in Libyan healthcare
facilities. Libyan J Med 4: 128-129.
10. Clinical and Laboratory Standards Institute/NCCLS (2005)
Performance Standards for Antimicrobial Susceptibility
Testing; Fifteenth Informational Supplement. CLSI/ NCCLS
documents M100-S15. USA.
11. Borg MA, Scicluna E, Kraker M, Bruinsma N (2006)
Antibiotic resistance in the southeastern Mediterranean –
preliminary results from the ARMed project. Euro Surveill
11: 164-167.
12. Madani TA (2002) Epidemiology and clinical features of
methicillin-resistant Staphylococcus aureus (MRSA) at the
University Hospital, Jeddah, Saudi Arabia. J KAU:Med Sci
10: 3-12.
13. Zorgani A, Shawerf O, Tawil K, El-Turki E, Ghenghesh KS
(2009) Inducible clindamycin resistance among
staphylococci isolated from burn patients. Libyan J Med 4:
149-152.
14. Anupurba S, Sen MR, Nath G, Sharma BM, Gulati AK,
Mohapatra TM (2003) Prevalence of methicillin resistant
staphylococcus aureus in a tertiary referral hospital in
eastern Uttar Pradesh. Indian J Med Microbiol 21: 49-51.
15. Schito GC (2002) Is antimicrobial resistance also subject to
globalization? Clin Microbiol Infect 8: 1-8.
16. Michel M and Gutmann L (1997) Methicillin-resistant
Staphylococcus aureus and vancomycin-resistant
enterococci: Therapeutic realities and possibilities. Lancet
349: 1901.
17. Markowitz N, Quinn EL, Saravolatz, LD (1992)
Trimethoprim-sulfamethoxazole compared with vancomycin
for the treatment of Staphylococcus aureus infection. Ann
Intern Med 117: 390.
18. Zorgani A, Elahmer O, Franka E, Grera A, Abudher A,
Ghenghesh KS (2009) Detection of methicillin-resistant
Staphylococcus aureus among healthcare workers in Libyan
hospitals. J Hosp Infect 73: 91-92.
4. Buzaid et al. - MRSA in a Libyan hospital J Infect Dev Ctries 2011; 5(10):723-726
726
Corresponding author
Abdel-Naser Elzouki, MBChB, MSc, MD, PhD, FRCP (UK)
Professor and Sr. Consultant of Clinical Medicine
Department of Medicine, Hamad Medical Corporation
Weill Cornell Medical College
PO Box 3050
Doha, Qatar
Telephone: (+974) 66022836
Fax: (+974) 44392489
Email: nelzouki_1999@yahoo.com; aelzouki@hmc.org.qa
Conflict of interests: No conflict of interests is declared.