This document presents a multi-sectoral provincial strategic plan for HIV/AIDS, STIs, and TB in KwaZulu-Natal for 2012-2016. It outlines the background and review process, structure and purpose of the plan, priority areas, and results framework. The priority areas are addressing social determinants, preventing new infections, sustaining health and reducing mortality, and protecting human rights. The plan aims to coordinate the provincial response through governance structures and implementation at ward level through Operation Sukuma Sakhe. District and local AIDS councils and civil society are urged to finalize plans aligned with the provincial strategic plan.