איך להפוך רעיון מבריק למיזם אינטרנט עובד חלק בTsvika Kleinman
חלק ב' בסדרת המאמרים הסוקרת את הדרך המרתקת והמאתגרת אשר עומדת בפני יזם אינטרנט, החל משלב הרעיון ועד לשלבי המימוש האחרונים כולל מתן כלים פרקטיים ליישום במהלך הדרך ודוגמאות רלוונטיות.
A preface to biofeedback and the three underlying disciplines it is based on - physiology, psychology and Information technology (Peek, C.J. (Second Edition). In M.S. Schwartz, Biofeedback A Practitioner's Guide).
Presentation of a volunteering project where computer savvy middle school gifted students collect old computer software, fix it, and donate the refurbished computer to people from though socio-economical background. Presented in 2004. Hebrew
The document discusses providing IT outsourcing services to businesses in Israel. It describes setting up an IT outsourcing company that would offer various IT services like website development, IT infrastructure management, and IT security. The outsourcing company would help businesses implement new computer systems and transfer their IT departments to manage costs and focus on their core business activities.
The document discusses providing IT outsourcing services to businesses in Israel. It describes setting up an IT outsourcing company that would offer various IT services like website development, IT infrastructure management, and IT security. The outsourcing company would help businesses implement new computer systems and transfer their IT departments to manage costs and focus on their core business activities.
The summary analyzes the performance of a hypothetical wind turbine over several years:
1) In its first year, the turbine generated 9781 kWh of energy, exceeding expectations.
2) Over the next few years, annual generation decreased slightly but remained steady at around 5000 kWh per year.
3) By its 10th year, the turbine was still producing but required maintenance to address wear, generating 4300 kWh that year before being decommissioned.
The document discusses setting up a system to manage multiple projects and clients. It suggests implementing an ERP system to integrate various functions like accounting, inventory management, customer relationship management etc. It also talks about defining standardized "project types" to categorize different projects and clients for reporting purposes. Finally, it discusses training employees on use of the new ERP system and client/project management processes.
1. The document provides instructions for creating a new SPSS data file and entering data using the SPSS Data Editor.
2. It describes opening an existing data file, viewing the data, and using different SPSS windows like the Data Editor and Variable View.
3. The summary concludes by outlining the steps to create a new empty data file in SPSS to then enter data for analysis.
איך להפוך רעיון מבריק למיזם אינטרנט עובד חלק בTsvika Kleinman
חלק ב' בסדרת המאמרים הסוקרת את הדרך המרתקת והמאתגרת אשר עומדת בפני יזם אינטרנט, החל משלב הרעיון ועד לשלבי המימוש האחרונים כולל מתן כלים פרקטיים ליישום במהלך הדרך ודוגמאות רלוונטיות.
A preface to biofeedback and the three underlying disciplines it is based on - physiology, psychology and Information technology (Peek, C.J. (Second Edition). In M.S. Schwartz, Biofeedback A Practitioner's Guide).
Presentation of a volunteering project where computer savvy middle school gifted students collect old computer software, fix it, and donate the refurbished computer to people from though socio-economical background. Presented in 2004. Hebrew
The document discusses providing IT outsourcing services to businesses in Israel. It describes setting up an IT outsourcing company that would offer various IT services like website development, IT infrastructure management, and IT security. The outsourcing company would help businesses implement new computer systems and transfer their IT departments to manage costs and focus on their core business activities.
The document discusses providing IT outsourcing services to businesses in Israel. It describes setting up an IT outsourcing company that would offer various IT services like website development, IT infrastructure management, and IT security. The outsourcing company would help businesses implement new computer systems and transfer their IT departments to manage costs and focus on their core business activities.
The summary analyzes the performance of a hypothetical wind turbine over several years:
1) In its first year, the turbine generated 9781 kWh of energy, exceeding expectations.
2) Over the next few years, annual generation decreased slightly but remained steady at around 5000 kWh per year.
3) By its 10th year, the turbine was still producing but required maintenance to address wear, generating 4300 kWh that year before being decommissioned.
The document discusses setting up a system to manage multiple projects and clients. It suggests implementing an ERP system to integrate various functions like accounting, inventory management, customer relationship management etc. It also talks about defining standardized "project types" to categorize different projects and clients for reporting purposes. Finally, it discusses training employees on use of the new ERP system and client/project management processes.
1. The document provides instructions for creating a new SPSS data file and entering data using the SPSS Data Editor.
2. It describes opening an existing data file, viewing the data, and using different SPSS windows like the Data Editor and Variable View.
3. The summary concludes by outlining the steps to create a new empty data file in SPSS to then enter data for analysis.
דו"ח סביבתי-כלכלי חדש אשר הוזמן ע"י הקואליציה לבריאות הציבור מאת פרופ' ניר בקר, מקשר לראשונה בין עלות הזיהום כתוצאה מעליית התחלואה. הדו"ח התמקד בשני סוגי סרטן ספציפיים - סרטן הריאות וסרטן שלפוחית השתן - והראה בשניהם כי באזור חיפה עלויות הזיהום הנגרם כתוצאה מעודף תחלואה בשני סוגי סרטן אלו מגיע לכדי 123 מיליון ש"ח בשנה. אומדנים אלו אמורים להוות כלי בקבלת החלטות.
1. The document discusses a meeting notification for a committee meeting.
2. Key details provided include the date and time of the meeting, as well as the agenda items to be discussed.
3. The notification indicates that the meeting's minutes from a previous meeting in 9002 will be approved.
The document discusses the trading of stocks on the Tel Aviv Stock Exchange. It explains some key terms related to trading, such as market maker stocks and limit orders. It also provides examples of trading times and price fluctuations for different stocks.
1. The document discusses options for opting-in and opting-out of receiving spam emails and SMS messages.
2. It provides tips for marketers on obtaining consent and ensuring people can easily unsubscribe from communications.
3. The last part includes a question and answer section about a marketer's spam filters and compliance with regulations.
The document provides information on various chemical substances and their properties. It lists several substances including bromine, chlorine, chromium, and phthalates. For each substance, it briefly describes the substance's physical and chemical characteristics, common industrial uses, and potential health effects. The document also references regulatory agencies and provides some additional context on substance classifications and restrictions.
The document summarizes research on how heart rate variability can provide insights into the autonomic nervous system. It discusses how the intervals between heartbeats (IBI) are regulated by two divisions of the autonomic nervous system - the sympathetic and parasympathetic systems. Changes in heart rate variability measured from IBI can reveal whether parasympathetic or sympathetic influences are predominant at different times. Key brain areas involved in autonomic control including the dorsal motor nucleus and nucleus ambiguus are also summarized.
The document discusses EMG (electromyography) testing and interpretation. EMG testing uses electrodes placed on the skin to detect and record electrical signals from muscles. The results are analyzed to evaluate nerves and diagnose muscular or neurological conditions. Common terms used in EMG results include "interference pattern" which refers to overlapping electrical signals, and "fibrillation" which indicates muscle damage. The summary provides an example of using EMG to evaluate a patient's "winking" muscle and explains how the results were interpreted.
ITIL (IT Infrastructure Library) provides best practices for IT service management. It aims to align IT services with business needs and improve the quality of IT services. The framework covers processes such as incident management, problem management, change management, and configuration management. ITIL is organized into five core publications that describe procedures for improving services and reducing disruptions: service strategy, service design, service transition, service operation, and continual service improvement.
This document provides information about security services offered by Moshav Bnei Zion including endpoint protection, network access control, security information and event management, URL filtering, and more. The moshav upgraded its security in 2021 by adding several new security solutions to protect members. Key solutions mentioned include endpoint protection, NAC, SIEM/SOC, and URL filtering.
1. The document discusses how BPM (Business Process Management) can help organizations improve processes and systems.
2. It provides examples of how BPM was used to streamline an ERP system implementation and ensure compliance with SOX regulations.
3. The document recommends that the company discussed should implement BPM to document processes, integrate systems, and continuously improve operations.
The Ministry of Internal Security held a discussion to approve the "VCM Project" for developing cyber defense capabilities.
1. The discussion summarized the project's goals of establishing a team to develop a system to detect cyber attacks in various government ministries.
2. The project will be implemented in the "Cyber Defense Administration 2591" department.
3. The key decisions were to appoint a project manager, update the "Head of Divisions" on the progress, and notify the relevant experts if any issues arise with the timeline.
The document discusses how a Customer Relationship Management (CRM) system can be integrated with other business systems and technologies to improve customer service. It recommends linking the CRM system to back-office systems using EAI or screen scraping to share customer data. It also suggests analyzing CRM data using Business Intelligence tools to gain insights into customer behavior and improve marketing strategies.
- Israeli soldier Ori Srour was injured in Operation Protective Edge in Gaza in 2014 and became paralyzed from the waist down.
- In 2022, Ori decided to complete the Israel Trail, a hiking trail the length of Israel, in his wheelchair to raise money for paralysis treatment research.
- Ori began his hike on March 1st, 2022 and completed the Israel Trail on June 6th, 2022, finishing the 1000km route in 98 days.
1. A committee meeting was held on June 6th, 2022 at 64 Shlomti St.
2. The meeting discussed adjusting the budget ratios from 90/10 to 90/40.
3. It was decided to notify the relevant parties about changing the budget ratios.
O documento descreve a importância de sonhar, lutar constantemente para realizar seus sonhos e nunca desistir dos contratempos. Ele também fala sobre a força do pensamento positivo e da fé para transformar sonhos em realidade. Por fim, apresenta detalhes sobre a autora, incluindo seus sonhos de adotar crianças e animais e conhecer novos lugares.
Motion sickness, also known as kinetosis, occurs when there is a disagreement between visual cues and vestibular cues. The brain becomes confused and causes nausea and vomiting. There are several theories that attempt to explain why motion sickness occurs, including that it is an evolutionary response to prevent the ingestion of toxins. In general, motion sickness can be reduced by keeping one's vision fixed on the external world to reduce conflicting signals to the brain.
O autor argumenta que dizer "eu te amo" não é suficiente para demonstrar amor. Sentir-se amado requer mais do que palavras - requer apoio real, interesse na vida do outro, preocupação quando as coisas não vão bem e conforto durante momentos difíceis. Sentir-se amado também significa ser aceito completamente e ter espaço para falar sobre tudo sem medo de julgamento.
Sally Kleinfeldt's presentation at the Plone Conference 2008 in Washington DC about using Plone, a leading open source content management system, to run a small business.
El documento habla sobre la importancia de cuidar la naturaleza y no contaminarla. Nos recuerda que depende de nosotros mantener limpios los lugares naturales y depositar la basura en su lugar correspondiente. Cada persona puede poner su granito de arena al no dejar basura y ayudar a cuidar el medio ambiente.
דו"ח סביבתי-כלכלי חדש אשר הוזמן ע"י הקואליציה לבריאות הציבור מאת פרופ' ניר בקר, מקשר לראשונה בין עלות הזיהום כתוצאה מעליית התחלואה. הדו"ח התמקד בשני סוגי סרטן ספציפיים - סרטן הריאות וסרטן שלפוחית השתן - והראה בשניהם כי באזור חיפה עלויות הזיהום הנגרם כתוצאה מעודף תחלואה בשני סוגי סרטן אלו מגיע לכדי 123 מיליון ש"ח בשנה. אומדנים אלו אמורים להוות כלי בקבלת החלטות.
1. The document discusses a meeting notification for a committee meeting.
2. Key details provided include the date and time of the meeting, as well as the agenda items to be discussed.
3. The notification indicates that the meeting's minutes from a previous meeting in 9002 will be approved.
The document discusses the trading of stocks on the Tel Aviv Stock Exchange. It explains some key terms related to trading, such as market maker stocks and limit orders. It also provides examples of trading times and price fluctuations for different stocks.
1. The document discusses options for opting-in and opting-out of receiving spam emails and SMS messages.
2. It provides tips for marketers on obtaining consent and ensuring people can easily unsubscribe from communications.
3. The last part includes a question and answer section about a marketer's spam filters and compliance with regulations.
The document provides information on various chemical substances and their properties. It lists several substances including bromine, chlorine, chromium, and phthalates. For each substance, it briefly describes the substance's physical and chemical characteristics, common industrial uses, and potential health effects. The document also references regulatory agencies and provides some additional context on substance classifications and restrictions.
The document summarizes research on how heart rate variability can provide insights into the autonomic nervous system. It discusses how the intervals between heartbeats (IBI) are regulated by two divisions of the autonomic nervous system - the sympathetic and parasympathetic systems. Changes in heart rate variability measured from IBI can reveal whether parasympathetic or sympathetic influences are predominant at different times. Key brain areas involved in autonomic control including the dorsal motor nucleus and nucleus ambiguus are also summarized.
The document discusses EMG (electromyography) testing and interpretation. EMG testing uses electrodes placed on the skin to detect and record electrical signals from muscles. The results are analyzed to evaluate nerves and diagnose muscular or neurological conditions. Common terms used in EMG results include "interference pattern" which refers to overlapping electrical signals, and "fibrillation" which indicates muscle damage. The summary provides an example of using EMG to evaluate a patient's "winking" muscle and explains how the results were interpreted.
ITIL (IT Infrastructure Library) provides best practices for IT service management. It aims to align IT services with business needs and improve the quality of IT services. The framework covers processes such as incident management, problem management, change management, and configuration management. ITIL is organized into five core publications that describe procedures for improving services and reducing disruptions: service strategy, service design, service transition, service operation, and continual service improvement.
This document provides information about security services offered by Moshav Bnei Zion including endpoint protection, network access control, security information and event management, URL filtering, and more. The moshav upgraded its security in 2021 by adding several new security solutions to protect members. Key solutions mentioned include endpoint protection, NAC, SIEM/SOC, and URL filtering.
1. The document discusses how BPM (Business Process Management) can help organizations improve processes and systems.
2. It provides examples of how BPM was used to streamline an ERP system implementation and ensure compliance with SOX regulations.
3. The document recommends that the company discussed should implement BPM to document processes, integrate systems, and continuously improve operations.
The Ministry of Internal Security held a discussion to approve the "VCM Project" for developing cyber defense capabilities.
1. The discussion summarized the project's goals of establishing a team to develop a system to detect cyber attacks in various government ministries.
2. The project will be implemented in the "Cyber Defense Administration 2591" department.
3. The key decisions were to appoint a project manager, update the "Head of Divisions" on the progress, and notify the relevant experts if any issues arise with the timeline.
The document discusses how a Customer Relationship Management (CRM) system can be integrated with other business systems and technologies to improve customer service. It recommends linking the CRM system to back-office systems using EAI or screen scraping to share customer data. It also suggests analyzing CRM data using Business Intelligence tools to gain insights into customer behavior and improve marketing strategies.
- Israeli soldier Ori Srour was injured in Operation Protective Edge in Gaza in 2014 and became paralyzed from the waist down.
- In 2022, Ori decided to complete the Israel Trail, a hiking trail the length of Israel, in his wheelchair to raise money for paralysis treatment research.
- Ori began his hike on March 1st, 2022 and completed the Israel Trail on June 6th, 2022, finishing the 1000km route in 98 days.
1. A committee meeting was held on June 6th, 2022 at 64 Shlomti St.
2. The meeting discussed adjusting the budget ratios from 90/10 to 90/40.
3. It was decided to notify the relevant parties about changing the budget ratios.
O documento descreve a importância de sonhar, lutar constantemente para realizar seus sonhos e nunca desistir dos contratempos. Ele também fala sobre a força do pensamento positivo e da fé para transformar sonhos em realidade. Por fim, apresenta detalhes sobre a autora, incluindo seus sonhos de adotar crianças e animais e conhecer novos lugares.
Motion sickness, also known as kinetosis, occurs when there is a disagreement between visual cues and vestibular cues. The brain becomes confused and causes nausea and vomiting. There are several theories that attempt to explain why motion sickness occurs, including that it is an evolutionary response to prevent the ingestion of toxins. In general, motion sickness can be reduced by keeping one's vision fixed on the external world to reduce conflicting signals to the brain.
O autor argumenta que dizer "eu te amo" não é suficiente para demonstrar amor. Sentir-se amado requer mais do que palavras - requer apoio real, interesse na vida do outro, preocupação quando as coisas não vão bem e conforto durante momentos difíceis. Sentir-se amado também significa ser aceito completamente e ter espaço para falar sobre tudo sem medo de julgamento.
Sally Kleinfeldt's presentation at the Plone Conference 2008 in Washington DC about using Plone, a leading open source content management system, to run a small business.
El documento habla sobre la importancia de cuidar la naturaleza y no contaminarla. Nos recuerda que depende de nosotros mantener limpios los lugares naturales y depositar la basura en su lugar correspondiente. Cada persona puede poner su granito de arena al no dejar basura y ayudar a cuidar el medio ambiente.
This document discusses how to adopt agile techniques for managing Plone projects with distributed, part-time teams on a fixed budget. Key points include:
- Defining roles like project owner, developer, designer, and project manager
- Scheduling projects into planning, deployment, and development iterations
- Using tools like Trac, Pivotal Tracker, ScrumDo, and Google Docs to facilitate communication, tracking stories and tasks, and planning iterations
- Integrating UX/UI design by including designers in the team and having them work closely with developers
The article discusses the concept of the "shadow self" and how it relates to the teachings. It states that every person has a shadow self that holds repressed parts of oneself. Facing one's shadow self can help with personal growth and understanding oneself on a deeper level. The teachings encourage examining one's shadow to integrate these hidden parts and achieve wholeness.
The document summarizes the establishment and development of the American colonies. It discusses the founding of Jamestown in 1607 and the growth of the 13 original English colonies along the eastern coast of North America between the 17th and 18th centuries. It also describes the founding of Philadelphia in the late 17th century and the role of William Penn in establishing it as a city that promoted religious freedom.
The document provides advice for improving one's situation. It recommends thinking positively, focusing on solutions rather than problems, and taking small steps towards goals rather than expecting immediate change. The overall message is to have patience and make gradual progress through optimism and perseverance.
The document provides guidance for improving a community through civic participation. It recommends bringing people together to discuss important issues respectfully and find solutions that benefit everyone. Volunteers should organize activities that strengthen relationships and make the community a better place through their combined efforts.
A security camera captured footage of an unusual incident:
- A large black bear entered an empty mini-market in the early hours of the morning.
- The bear rummaged through the store, helping itself to snacks from the shelves.
- After eating, the bear left without causing any damage.
This document discusses best practices for portfolio management in organizations and the role of a Project Management Office (PMO). It recommends that a PMO can help standardize processes, facilitate knowledge sharing between projects, and ensure projects are aligned with organizational strategy. A PMO is especially beneficial for small to medium businesses to help coordinate their project activities.
This document discusses best practices for portfolio management in organizations and the role of a Project Management Office (PMO). It recommends that a PMO can help standardize processes, facilitate knowledge sharing between projects, and ensure projects are aligned with organizational strategy. A PMO is especially beneficial for small to medium businesses to help coordinate their project activities.
ITIL (IT Infrastructure Library) provides best practices for IT service management. It aims to align IT services with business needs and improve the quality of IT services. The framework covers processes such as incident management, problem management, change management, and configuration management. ITIL is organized into five core publications that describe procedures for improving services and reducing disruptions: service strategy, service design, service transition, service operation, and continual service improvement.
ITIL (IT Infrastructure Library) provides best practices for IT service management. It aims to align IT services with business needs and improve the quality of IT services. The framework covers processes such as incident management, problem management, change management, and configuration management. ITIL is organized into five core publications that describe procedures for improving services and reducing disruptions: service strategy, service design, service transition, service operation, and continual service improvement.
The professor tries to convince the skeptic that the rabbit's foot is lucky by recounting stories of times when having it seemed to help avoid harm or get good results. However, the skeptic remains unconvinced that the rabbit's foot itself is truly bringing luck, noting that sometimes bad things still happen even with it. In the end, the professor accepts that the skeptic will not be persuaded but hopes to keep the rabbit's foot anyway in case it could possibly help.
1. The report summarizes the findings of a case study on air pollution in Haifa Bay-Acre Industrial Complex in Israel.
2. It identifies several sources of air pollution in the region, including industrial plants, transportation, and power stations.
3. The report recommends reducing air pollution by enforcing emissions standards, using cleaner fuels, and increasing monitoring and public awareness of air quality issues.
דו"ח זיהום אוויר - מקרה מפרץ חיפה ועכוguest6b9afbd
The document summarizes a case study report on air pollution and public health in Haifa Bay-Acre Industrial Complex in Israel from 2002. It finds that industrial emissions contribute significantly to air pollution in the region. It recommends improving emissions monitoring and enforcing regulations to reduce pollution and its health impacts on local communities.
The document discusses the phenomenon of thick urban rooms. It talks about moving from thickness to thinness and finding clarity within density. It notes that now is the time to observe from within this thickness and discusses the thickness of the urban environment.
The document summarizes the results of a study on microgrids and their ability to stabilize grid frequency. Key points:
- A microgrid was able to stabilize grid frequency and help prevent blackouts during a 13.4% drop in frequency caused by the disconnection of a power plant.
- The microgrid increased its power output to help balance the grid during fluctuations.
- Further studies showed that microgrids can provide frequency support to main grids and help stabilize frequency during abnormal events.
The document discusses a group traveling together and encountering various challenges along the way. It describes stopping to rest, continuing the journey, and eventually making camp for the night after a long day of traveling. The group works together cooperatively to overcome obstacles.
קומיוגן פתרונות לזרימת מידע במגזר הפיננסיEyal Sassoon
The document discusses Knowledge Experts, a company that provides expertise to help businesses improve their knowledge management processes. It lists several services the company offers, including training employees, implementing CRM systems, setting service level agreements, and helping manage knowledge repositories. The company aims to help clients effectively capture, share and utilize knowledge to improve customer service and business operations.
The document discusses setting up a new website called cut-com. It recommends connecting the website to a hosting service called Web-Web to allow for easy management and updates. The hosting service will also provide security and backups to protect the website and its content.
The document discusses different approaches to psychotherapy, including cognitive behavioral therapy and psychodynamic therapy. It compares the cognitive behavioral approach, which focuses on specific techniques, to the psychodynamic approach, which emphasizes the relationship between therapist and patient. The document also outlines some key concepts in cognitive behavioral therapy such as behavioral methods, cognitive methods, and physiological control.
This document summarizes evidence from research studies on the effectiveness of biofeedback-based interventions for various health conditions, rating the level of evidence on a scale from 1 to 4. It finds level 1 evidence for biofeedback helping problems like anxiety, arthritis, asthma, chronic pain, diabetes and others. Higher levels of evidence (3-4) are found for biofeedback reducing headaches, high blood pressure, insomnia, irritable bowel syndrome and temporomandibular disorders. The strongest evidence is for randomized controlled trials comparing biofeedback to no treatment or an alternative.
The study evaluated the effects of a universal, teacher-led intervention program implemented in Israeli schools prior to rocket attacks, finding that children who received the resilience-focused intervention displayed significantly lower posttraumatic stress and stress/mood symptoms compared to the control group who did not receive the intervention. The teacher-based approach aimed to enhance children's preparedness for mass trauma through education on stress and coping skills training.
1. Neal Miller's research in the 1960s challenged the prevailing view that autonomic nervous system responses could not be conditioned through operant conditioning. His experiments demonstrated that autonomic responses like heart rate could be conditioned in animals. (2) However, whether autonomic operant conditioning occurs in humans remains an open question that biofeedback clinicians still grapple with today. (3) The authors propose a new model of "dyadic biofeedback" that recognizes the regulatory capacity of interpersonal interactions and allows for real-time training of these interactions using dual physiological screens.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise boosts blood flow and levels of neurotransmitters and endorphins which elevate and stabilize mood.
The document discusses stress management for allied health professionals. It provides an overview of stress physiology, explaining the sympathetic nervous system, parasympathetic nervous system, and their roles in the fight or flight response. It also discusses modern stressors, cognitive behavioral approaches, and techniques for managing stress through exercise, nutrition, mind-body practices like yoga, and heart rate variability biofeedback training.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
The document discusses different fields of study including physics, philosophy, psychology, and biology. It also mentions concepts like education, knowledge, and thinking.
Congestive Heart failure is caused by low cardiac output and high sympathetic discharge. Diuretics reduce preload, ACE inhibitors lower afterload, beta blockers reduce sympathetic activity, and digitalis has inotropic effects. Newer medications target vasodilation and myosin activation to improve heart efficiency while lowering energy requirements. Combination therapy, following an assessment of cardiac function and volume status, is the most effective strategy to heart failure care.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...Jim Jacob Roy
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
1. מחלת התנועה
מחלת התנועה ) ,(Motion Sicknessהמכונה לעתים quot;מחלת יםquot;, מתבטאת בחולשה, בבחילות
ובהקאות, למשל בעת נסיעה בכלי רכב שונים. לעומת בעיות אחרות, תסמונת זו מיוחדת בכך שאפשר
לעוררה במכוון בתנאי מעבדה, הליך המקל בביצוע מחקר מבוקר. נוכל להיעזר בהצגת הטיפול
בביופידבק במחלת התנועה כדי להדגים את העקרונות הבסיסיים המאפיינים את הטיפול בשיטה זו.
תחילה נפנה לתיאור התופעה ומקורה. מחלת התנועה תוקפת כאשר אדם נחשף לדפוס תנועה שאינו
מורגל בו. הדבר בולט מאוד בחיל הים שבו יש כלי שיט רבים, וקרוב לשני שלישים מן החיילים
המשרתים על סיפונם חשים ברע לעתים תכופות. גם בטיסה, בעיקר במטוסים קטנים בתנאי מזג אוויר
קשים, בנסיעה ברכב או במתקני שעשועים אדם עלול לסבול מבחילות ומהקאות.
בניגוד לתפישה הרווחת מקור המחלה אינו בקיבה, אלא באופן שבו המוח מגיב על דפוס התנועה הנקלט
בחושים השונים. חושים אלו כוללים את מערכת שיווי המשקל הנמצאת באוזן הפנימית, את מערכת
הראייה, בעיקר הראייה הפריפרית האחראית לזיהוי תנועה, וכמובן את המערכת הפרופריוצפטורית
המזהה תנועה באמצעות עיבוד מידע הנוגע לשינויים בלחץ על השלד ועל השרירים.
ההסבר המקובל למחלת התנועה מבוסס על תאוריית העימות: כאשר מערכות חישה מקבלות מידע
סותר, המוח מתקשה לעבד את המידע ומתעוררת שורת תגובות אוטונומיות המשפיעות גם על הקיבה.
לדוגמה, מערכת שיווי המשקל של אדם העומד בבטן ספינה quot;תדווחquot; למוח על תנודות, ואילו מערכת
הראייה quot;תדווחquot; על מצב של היעדר תנועה )בחלל הסגור(. בדרך-כלל נחלשים התסמינים עם הזמן,
למשל, לאחר כמה ימי הפלגה, כנראה משום שהמוח מסתגל ולומד לשלב את דפוס התנועה החדש,
והמערכת האוטונומית חוזרת לוויסות תקין.
מעניין לציין כי החשיפה לגירוי של תנועה בתנאים סבילים )או נייחים( איננה הגורם המכריע בהופעת
התסמונת. חקירת גורמים שונים המשפיעים על האופן שבו המוח מעבד מידע חושי סותר שופכת אור על
תופעה מורכבת זו. למשל, נוסעים באוטובוס יפ ַתחו מחלת תנועה לעתים תכופות, ואילו נהג הרכב,
החשוף לאותם התנאים, יחוש את סימני התופעה לעתים נדירות בלבד. מכאן אפשר לשער כי מרכיב
השליטה במצב מרכזי בתופעה זו; ההנחה הזאת נבחנה ואוששה בכלים אמפיריים.
בשל העובדה כי %05 מן האסטרונאוטים סובלים ממחלת תנועה, יזמה סוכנות החלל האמריקנית סדרת
מחקרים חשובים. בעקבות התעוררות ההפרעה במעבדה נצפו האצה בקצב הלב, עלייה במוליכות
2. החשמלית של העור וירידה בטמפרטורת העור. כך הובהר כי למערכת העצבים האוטונומית יש תפקיד
בביטויי המחלה.
ואכן מחלת התנועה מתבטאת בתגובה אוטונומית בולטת: חיוורון )המשקף היצרות נימי דם היקפיים(,
הזעה בידיים, בחילה, הקאות וכו'. למעשה, באיברי מטרה שונים בגוף, וביניהם גם מערכת העיכול, קיים
עצבוב סימפתטי, ולפיכך גריית המערכת האוטונומית עלולה להתבטא בבחילה ובהקאות. תופעה זו
מוכרת כאשר אדם נחשף למידע מזעזע או לאירוע טראומטי, ובעקבותיהם נתקף בחילה והקאות )ללא
כל קשר לתנועה(.
אנשים נבדלים מאוד זה מזה בנטייתם לפתח מחלת תנועה. ישנם החשים ברע כמעט בכל תנאי תנועה,
ואילו אחרים לא יחוו אי-נוחות גם בתנאי תנועה קשים )כביש משובש, ים סוער וכד'(. בעבר נטו לקשור
הבדלי רגישות אלו להבדלים בתפקוד איברי שיווי המשקל, אך מתברר כי תגובתיות יתר של המערכת
האוטונומית מנבאת רגישות למחלת התנועה בצורה הטובה ביותר.
בתנאים שבהם אי אפשר להרחיק את גורם ההפרעה או לשלוט בו, יש לטפח שליטה עצמית בתגובת
הגוף על הגירוי. על-פי המודל הטיפולי בביופידבק, מושא ההתערבות הטיפולית הוא התסמין הגופני
המסב סבל. התרגול יתמקד בביטוי התגובות הגופניות המטרידות בלי לנסות להשפיע על תהליכי עיבוד
מידע רלוונטיים )המקור לבעיה(. אם כן, מטרת התרגול תהיה להקטין את התגובתיות האוטונומית
כאמצעי להפחתת הרגישות למחלת התנועה.
למעשה, קיימים הבדלים בין-אישיים בדפוס התגובה האוטונומית על הגירוי מעורר ההפרעה. יש
המגיבים בעיקר בהאצת קצב הלב, ואצל אחרים תתבטא התופעה בעליית המוליכות החשמלית של
העור. לכן בתחילת הטיפול יבצע המטפל אבחון פסיכופיזיולוגי שיאפיין את דפוס התגובה האוטונומית על
מצב הדחק של המטופל. בעקבות האבחון יונחה הנבדק לתרגל שליטה במשתנים הפיזיולוגיים
הרלוונטיים בתנאים נוחים. לאחר שילמד לשלוט בכל אחד מן המשתנים האוטונומיים לחוד ויחד, יתבקש
לתרגל שליטה בתסמונת האוטונומית בתנאי תנועה קלים עד חריפים בהדרגה. התערבות טיפולית זו,
המשלבת חשיפה הדרגתית לגירוי מעורר ההפרעה מתוך הפעלת תגובה מתאימה, מכונה דה-
סנסטיזציה שיטתית )ראה פרק 5(. הטיפול ייעזר בהדמיה של מצבים המעוררים את מחלת התנועה.
למשל, הנבדק יתבקש לשבת בכיסא מיוחד המסתובב סביב צירו או לצדדים ויוצר גירוי תנועה חריף,
הנתון לבקרת המטפל.
3. מן הניסיון הנרכש בחיל הים נראה כי קשה להשיג מניעה מוחלטת של הבחילה, אך האימון בביופידבק
מפחית את השימוש של החיילים בתרופות ומאפשר להם לתפקד טוב יותר במהלך שירותם בים. מחלת
התנועה היא דוגמה ברורה לטיפול לא ייחודי, שאינו ממוקד במקור הבעיה, כי אם בביטוייה האוטונומיים.