Monofixation syndrome is a form of subnormal binocular vision characterized by small-angle strabismus, unilateral absolute facultative central suppression scotoma of less than 3 degrees, and peripheral fusion. It can be caused by conditions that surgically corrected strabismus, anisometropia, macular lesions, or a lack of symptoms. Diagnosis involves tests showing subnormal stereopsis, visual acuity differences between eyes, amblyopia, or retinal disease. Treatment may include amblyopia treatment, strabismus surgery, and follow-up care.