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PUPILLARY REACTION
DISORDERS
By- Raju Rathore
HIPPUS01
• It is seen in multiple sclerosis.
• It is characterised by alternate large rhythmic
pupillary
dilatation and constriction. It is often independent
of the light
stimulation.
MARCUS GUNN PUPIL (OR RELATIVE AFFERENT
PUPILLARY DEFECT—RAPD)
02
• It is seen in unilateral optic neuritis, retrobulbar neuritis or
multiple sclerosis.
• It is due to lesion in one of the optic nerves (Fig. 6-5).
• It is a pupillary reflex disorder characterised by smaller
constriction of both the pupils when light is focused on the
affected
eye.
• It is diagnosed by swinging flash light test. The test is
done
in a darkened room with the patient fixating at a distant
target.
On swinging a light from one eye to the other, stimulation of
02 However, rapid stimulation of the affected eye will lead to a
small dilatation which is also known as pupillary escape
ADIE’S PUPIL (OR TONIC PUPIL)03
ENTER TITLE ENTER TITLE ENTER TITLE
• It is usually an unilateral (in 80% of cases) dilated but
tonic
pupil (anisocoria).
• It is called “Adie’s pupil”, if the cause is not identified.
However, it is termed as “Tonic pupil” if the aetiology is
detected
02
• Etiology includes; viral infection of the ciliary ganglion or
the
short ciliary nerve (Fig. 6-5), injury to the ciliary ganglion
or
the short ciliary nerve, giant cell arteritis, syphilis, diabetes
mellitus, herpes zoster, orbital infection, etc.
• Bilateral Adie’s pupil is often seen in association with
syphilis
and sarcoidosis.
• Very poor pupillary light reflex response (both direct and
consensual).
ARGYLL–ROBERTSON PUPIL
• It is characterised by absence of pupillary
reaction to light
reflexes (both direct and consensual) and
retention of pupillary reaction on accommodation
and convergence (near reflex), i.e.
pupillary light near dissociation.
• The pupils are small and usually unequal.
• Vision is unaffected.
HORNER’S SYNDROME
• It is characterised by unilateral miosis, partial
ptosis, slight
elevation of the lower lid, enophthalmos and
heterochromia (in
congenital variety).
• It is occasionally accompanied by unilateral
absence of sweating
of the face (anhidrosis) and flushing of the face.
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Pupillary react disorders

  • 2. HIPPUS01 • It is seen in multiple sclerosis. • It is characterised by alternate large rhythmic pupillary dilatation and constriction. It is often independent of the light stimulation.
  • 3. MARCUS GUNN PUPIL (OR RELATIVE AFFERENT PUPILLARY DEFECT—RAPD) 02 • It is seen in unilateral optic neuritis, retrobulbar neuritis or multiple sclerosis. • It is due to lesion in one of the optic nerves (Fig. 6-5). • It is a pupillary reflex disorder characterised by smaller constriction of both the pupils when light is focused on the affected eye. • It is diagnosed by swinging flash light test. The test is done in a darkened room with the patient fixating at a distant target. On swinging a light from one eye to the other, stimulation of
  • 4. 02 However, rapid stimulation of the affected eye will lead to a small dilatation which is also known as pupillary escape
  • 5. ADIE’S PUPIL (OR TONIC PUPIL)03 ENTER TITLE ENTER TITLE ENTER TITLE • It is usually an unilateral (in 80% of cases) dilated but tonic pupil (anisocoria). • It is called “Adie’s pupil”, if the cause is not identified. However, it is termed as “Tonic pupil” if the aetiology is detected
  • 6. 02 • Etiology includes; viral infection of the ciliary ganglion or the short ciliary nerve (Fig. 6-5), injury to the ciliary ganglion or the short ciliary nerve, giant cell arteritis, syphilis, diabetes mellitus, herpes zoster, orbital infection, etc. • Bilateral Adie’s pupil is often seen in association with syphilis and sarcoidosis. • Very poor pupillary light reflex response (both direct and consensual).
  • 7.
  • 8. ARGYLL–ROBERTSON PUPIL • It is characterised by absence of pupillary reaction to light reflexes (both direct and consensual) and retention of pupillary reaction on accommodation and convergence (near reflex), i.e. pupillary light near dissociation. • The pupils are small and usually unequal. • Vision is unaffected.
  • 9.
  • 10. HORNER’S SYNDROME • It is characterised by unilateral miosis, partial ptosis, slight elevation of the lower lid, enophthalmos and heterochromia (in congenital variety). • It is occasionally accompanied by unilateral absence of sweating of the face (anhidrosis) and flushing of the face.
  • 11.