The skin consists of three layers - the epidermis, dermis, and hypodermis. The epidermis is the outermost layer and contains four types of cells including keratinocytes. It has several sublayers that provide barriers and protection. The dermis lies beneath the epidermis and contains collagen, elastin, and blood vessels that supply the epidermis. It is made of two layers and anchors the epidermis. The deepest layer, the hypodermis, binds the skin to underlying tissue and contains fat cells that provide padding and insulation.