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MITOCHONDRIA
THE POWER HOUSE OF CELL
DR. SANDHYA
ASSOCIATE PROF. BOTANY
INTRODUCTION
• First observed- Kollikar 1850
• 1894- Altman- Bioblast
• 1898- Carl Benda- Mitochondria
• 1904- Friedrich Meves- plants (Nymphaea alba)
• Respiratory organelle
2
STRUCTURE
3
COMPOSITION
MEMBRANE
65-70%
Proteins
25-30 %
Lipids
(lecithin and
cephalin)
Inner membrane –
rich in Cardiolipin,
highly
impermeable
ENZYMES
Outer membrane-
monoamine
oxidase,
cytochrome
reductase
Outer chamber-
adenylate kinase,
DNAase I
Inner membrane-
Enz. ETC &
oxidative
phosphorylation,
cytochrome oxidase
Matrix- Enz. Krebs
cycle, β-oxidation,
malate
dehydrogenase
4
MITOCHONDRIA- A Semi-Autonomous
Organelle
• Synthesize proteins- DNA & Ribosome
• DNA-
• Double stranded, circular
• More than one copy may be present
• Replication- under nuclear control
• Compared to nuclear DNA- mt DNA has
• More GC pairs
• Shorter
• Circular
• Devoid of histones
5
FUNCTIONS
Cellular
respiration
Beta-
oxidation
Heat
production
6
7
CELLULAR
RESPIRATION
Glycolysis
Oxi.
decarboxylation
Krebs
cycle
ETC & Oxi.
Phosphorylation
8
9
10
11
12
13
β-OXIDATION
HEAT PRODUCTION
• Glucose- oxidized- energy- a part of it
is lost as heat to regulate body
temperature in warm blooded animals
• In hibernating species- brown fat (high
conc. of mitochondria)- important in
temperature regulation
• Mitochondria in brown fat catalyzes
electron transport but are less efficient
at producing ATP
14

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MITOCHONDRIA.ppsx