Mise-en-scene refers to everything visible within the frame of a shot that can create meaning, including color, costume, props, set design, lighting, and the blocking and performance of actors. The key areas of mise-en-scene are color, costume, props, set/location, blocking and performance, and lighting. Color, costume, props, set design, blocking, and lighting can all be manipulated to convey specific meanings and influence the audience's interpretation of the events on screen.