This document discusses some key limitations of using spreadsheets for database management, including issues related to data redundancy, independence, consistency, integrity, and security. It notes that spreadsheets are not collaborative, lack functionality for transaction matching and compliance monitoring, and have data stored across multiple locations leading to inefficiencies. In contrast, databases provide relational data storage across tables, advanced querying abilities, and can handle large datasets and volumes of data more efficiently. The document also provides an example entity relationship diagram and database schema for a student misconduct case management system.