Students determined the age of the universe using an 11 inch telescope and they discover the necessary physical laws experimentally.
As a second step they developed a progressive series of mathematical models for the dynamics of the universe and calculated that the usual matter amounts only 5 % of all matter and energy in the universe.
Easy to use learning material is included for schools as well as for the interested public. More detailed learning material may be requested. The material has been tested successively for three age groups: With the conceptual material, students of classes 4 or higher can comprehend the topic. With more advanced material, students of class 7 or higher can evaluate the measurements mathematically. With fully advanced material, students of class 9 or higher can develop mathematical models for the dynamics of the universe and calculate the statistical significance of the measurements.
A highly magnetized twin-jet base pinpoints a supermassive black holeSérgio Sacani
Supermassive black holes (SMBH) are essential for the production of jets in radio-loud active galactic nuclei (AGN). Theoretical
models based on (Blandford & Znajek 1977, MNRAS, 179, 433) extract the rotational energy from a Kerr black hole, which could
be the case for NGC1052, to launch these jets. This requires magnetic fields on the order of 103 G to 104 G. We imaged the vicinity
of the SMBH of the AGN NGC1052 with the Global Millimetre VLBI Array and found a bright and compact central feature that is
smaller than 1.9 light days (100 Schwarzschild radii) in radius. Interpreting this as a blend of the unresolved jet bases, we derive the
magnetic field at 1 Schwarzschild radius to lie between 200 G and 8:3 104 G consistent with Blandford & Znajek models.
Students determined the age of the universe using an 11 inch telescope and they discover the necessary physical laws experimentally.
As a second step they developed a progressive series of mathematical models for the dynamics of the universe and calculated that the usual matter amounts only 5 % of all matter and energy in the universe.
Easy to use learning material is included for schools as well as for the interested public. More detailed learning material may be requested. The material has been tested successively for three age groups: With the conceptual material, students of classes 4 or higher can comprehend the topic. With more advanced material, students of class 7 or higher can evaluate the measurements mathematically. With fully advanced material, students of class 9 or higher can develop mathematical models for the dynamics of the universe and calculate the statistical significance of the measurements.
A highly magnetized twin-jet base pinpoints a supermassive black holeSérgio Sacani
Supermassive black holes (SMBH) are essential for the production of jets in radio-loud active galactic nuclei (AGN). Theoretical
models based on (Blandford & Znajek 1977, MNRAS, 179, 433) extract the rotational energy from a Kerr black hole, which could
be the case for NGC1052, to launch these jets. This requires magnetic fields on the order of 103 G to 104 G. We imaged the vicinity
of the SMBH of the AGN NGC1052 with the Global Millimetre VLBI Array and found a bright and compact central feature that is
smaller than 1.9 light days (100 Schwarzschild radii) in radius. Interpreting this as a blend of the unresolved jet bases, we derive the
magnetic field at 1 Schwarzschild radius to lie between 200 G and 8:3 104 G consistent with Blandford & Znajek models.
PROBING FOR EVIDENCE OF PLUMES ON EUROPA WITH HST/STISSérgio Sacani
Roth et al. (2014a) reported evidence for plumes of water venting from a southern high latitude
region on Europa – spectroscopic detection of off-limb line emission from the dissociation
products of water. Here, we present Hubble Space Telescope (HST) direct images of Europa in
the far ultraviolet (FUV) as it transited the smooth face of Jupiter, in order to measure absorption
from gas or aerosols beyond the Europa limb. Out of ten observations we found three in which
plume activity could be implicated. Two show statistically significant features at latitudes similar
to Roth et al., and the third, at a more equatorial location. We consider potential systematic
effects that might influence the statistical analysis and create artifacts, and are unable to find any
that can definitively explain the features, although there are reasons to be cautious. If the
apparent absorption features are real, the magnitude of implied outgassing is similar to that of the
Roth et al. feature, however the apparent activity appears more frequently in our data.
Exocometary gas in_th_hd_181327_debris_ringSérgio Sacani
An increasing number of observations have shown that gaseous debris discs are not an
exception. However, until now we only knew of cases around A stars. Here we present the first
detection of 12CO (2-1) disc emission around an F star, HD 181327, obtained with ALMA
observations at 1.3 mm. The continuum and CO emission are resolved into an axisymmetric
disc with ring-like morphology. Using a Markov chain Monte Carlo method coupled with
radiative transfer calculations we study the dust and CO mass distribution. We find the dust is
distributed in a ring with a radius of 86:0 0:4 AU and a radial width of 23:2 1:0 AU. At
this frequency the ring radius is smaller than in the optical, revealing grain size segregation
expected due to radiation pressure. We also report on the detection of low level continuum
emission beyond the main ring out to 200 AU. We model the CO emission in the non-LTE
regime and we find that the CO is co-located with the dust, with a total CO gas mass ranging
between 1:2 10 6 M and 2:9 10 6 M, depending on the gas kinetic temperature and
collisional partners densities. The CO densities and location suggest a secondary origin, i.e.
released from icy planetesimals in the ring. We derive a CO cometary composition that is
consistent with Solar system comets. Due to the low gas densities it is unlikely that the gas is
shaping the dust distribution.
First discovery of_a_magnetic_field_in_a_main_sequence_delta_scuti_star_the_k...Sérgio Sacani
Coralie Neiner do Laboratory for Space Studies and Astrophysics Instrumentation, LESIA (CNRS/Observatoire de Paris/UPMC/Université Paris Diderot) e Patricia Lampens (Royual OIbservatory of Belgium), descobriram a primeira estrela magnética do tipo delta Scuti, através de observações espectropolarimétricas, realizadas com o telescópio CFHT. As estrelas do tipo delta Scuti, são estrelas pulsantes, sendo que algumas delas mostram assinaturas atribuídas para um segundo tipo de pulsação. A descoberta mostra que isso é na verdade a assinatura de um campo magnético. Essa descoberta tem importantes implicações para o entendimento do interior das estrelas.
Dois tipos de estrelas pulsantes existem entre as estrelas com massa entre 1.5 e 2.5 vezes a massa do Sol: as estrelas do tipo delta Scuti e as estrelas do tipo gamma Dor. A teoria nos diz que as estrelas com temperatura entre 6900 e 7400 graus Kelvin podem ter ambos os tipos de pulsação. Essas são então chamadas de estrelas híbridas. Contudo, o satélite Kepler da NASA tem detectado um grande número de estrelas híbridas com temperaturas maiores ou menores do que esse limite pensado anteriormente. A existência dessas estrelas híbridas com temperaturas maiores é algo muito controverso, já que desafia o nosso entendimento sobre as estrelas pulsantes do tipo delta Scuti e gamma Dor.
PROBING FOR EVIDENCE OF PLUMES ON EUROPA WITH HST/STISSérgio Sacani
Roth et al. (2014a) reported evidence for plumes of water venting from a southern high latitude
region on Europa – spectroscopic detection of off-limb line emission from the dissociation
products of water. Here, we present Hubble Space Telescope (HST) direct images of Europa in
the far ultraviolet (FUV) as it transited the smooth face of Jupiter, in order to measure absorption
from gas or aerosols beyond the Europa limb. Out of ten observations we found three in which
plume activity could be implicated. Two show statistically significant features at latitudes similar
to Roth et al., and the third, at a more equatorial location. We consider potential systematic
effects that might influence the statistical analysis and create artifacts, and are unable to find any
that can definitively explain the features, although there are reasons to be cautious. If the
apparent absorption features are real, the magnitude of implied outgassing is similar to that of the
Roth et al. feature, however the apparent activity appears more frequently in our data.
Exocometary gas in_th_hd_181327_debris_ringSérgio Sacani
An increasing number of observations have shown that gaseous debris discs are not an
exception. However, until now we only knew of cases around A stars. Here we present the first
detection of 12CO (2-1) disc emission around an F star, HD 181327, obtained with ALMA
observations at 1.3 mm. The continuum and CO emission are resolved into an axisymmetric
disc with ring-like morphology. Using a Markov chain Monte Carlo method coupled with
radiative transfer calculations we study the dust and CO mass distribution. We find the dust is
distributed in a ring with a radius of 86:0 0:4 AU and a radial width of 23:2 1:0 AU. At
this frequency the ring radius is smaller than in the optical, revealing grain size segregation
expected due to radiation pressure. We also report on the detection of low level continuum
emission beyond the main ring out to 200 AU. We model the CO emission in the non-LTE
regime and we find that the CO is co-located with the dust, with a total CO gas mass ranging
between 1:2 10 6 M and 2:9 10 6 M, depending on the gas kinetic temperature and
collisional partners densities. The CO densities and location suggest a secondary origin, i.e.
released from icy planetesimals in the ring. We derive a CO cometary composition that is
consistent with Solar system comets. Due to the low gas densities it is unlikely that the gas is
shaping the dust distribution.
First discovery of_a_magnetic_field_in_a_main_sequence_delta_scuti_star_the_k...Sérgio Sacani
Coralie Neiner do Laboratory for Space Studies and Astrophysics Instrumentation, LESIA (CNRS/Observatoire de Paris/UPMC/Université Paris Diderot) e Patricia Lampens (Royual OIbservatory of Belgium), descobriram a primeira estrela magnética do tipo delta Scuti, através de observações espectropolarimétricas, realizadas com o telescópio CFHT. As estrelas do tipo delta Scuti, são estrelas pulsantes, sendo que algumas delas mostram assinaturas atribuídas para um segundo tipo de pulsação. A descoberta mostra que isso é na verdade a assinatura de um campo magnético. Essa descoberta tem importantes implicações para o entendimento do interior das estrelas.
Dois tipos de estrelas pulsantes existem entre as estrelas com massa entre 1.5 e 2.5 vezes a massa do Sol: as estrelas do tipo delta Scuti e as estrelas do tipo gamma Dor. A teoria nos diz que as estrelas com temperatura entre 6900 e 7400 graus Kelvin podem ter ambos os tipos de pulsação. Essas são então chamadas de estrelas híbridas. Contudo, o satélite Kepler da NASA tem detectado um grande número de estrelas híbridas com temperaturas maiores ou menores do que esse limite pensado anteriormente. A existência dessas estrelas híbridas com temperaturas maiores é algo muito controverso, já que desafia o nosso entendimento sobre as estrelas pulsantes do tipo delta Scuti e gamma Dor.
The Population of the Galactic Center Filaments: Position Angle Distribution ...Sérgio Sacani
We have examined the distribution of the position angle (PA) of the Galactic center filaments with lengths L > 66″ and
<66″ as well as their length distribution as a function of PA. We find bimodal PA distributions of the filaments, and
long and short populations of radio filaments. Our PA study shows the evidence for a distinct population of short
filaments with PA close to the Galactic plane. Mainly thermal, short-radio filaments (<66″) have PAs concentrated
close to the Galactic plane within 60° < PA < 120°. Remarkably, the short filament PAs are radial with respect to the
Galactic center at l < 0° and extend in the direction toward Sgr A*
. On a smaller scale, the prominent Sgr E H II
complex G358.7-0.0 provides a vivid example of the nearly radial distribution of short filaments. The bimodal PA
distribution suggests a different origin for two distinct filament populations. We argue that the alignment of the shortfilament population results from the ram pressure of a degree-scale outflow from Sgr A* that exceeds the internal
filament pressure, and aligns them along the Galactic plane. The ram pressure is estimated to be 2 × 106 cm−3 K at a
distance of 300 pc, requiring biconical mass outflow rate 10−4 Me yr−1 with an opening angle of ∼40°. This outflow
aligns not only the magnetized filaments along the Galactic plane but also accelerates thermal material associated with
embedded or partially embedded clouds. This places an estimate of ∼6 Myr as the age of the outflow.
Probing the innermost_regions_of_agn_jets_and_their_magnetic_fields_with_radi...Sérgio Sacani
Desde 1974, observações feitas com o chamado Long Baseline Interferometry, ou VLBI, combinaram sinais de um objeto cósmico recebidos em diferentes rádio telescópios espalhados pelo globo para criar uma antena com o tamanho equivalente à maior separação entre elas. Isso fez com que fosse possível fazer imagens com uma nitidez sem precedentes, com uma resolução 1000 vezes melhor do que Hubble consegue na luz visível. Agora, uma equipe internacional de astrônomos quebrou todos os recordes combinando 15 rádio telescópios na Terra e a antena de rádio da missão RadioAstron, da agência espacial russa, na órbita da Terra. O trabalho, liderado pelo Instituto de Astrofísica de Andalucía, o IAA-CSIC, forneceu novas ideias sobre a natureza das galáxias ativas, onde um buraco negro extremamente massivo engole a matéria ao redor enquanto simultaneamente emite um par de jatos de partículas de alta energia e campos magnéticos a velocidades próximas da velocidade da luz.
Observações feitas no comprimento de onda das micro-ondas são essenciais para explorar esses jatos, já que os elétrons de alta energia se movendo em campos magnéticos são mais proficientes em produzir micro-ondas. Mas a maioria das galáxias ativas com jatos brilhantes estão a bilhões de anos-luz de distância da Terra, de modo que esses jatos são minúsculos no céu. Desse modo a alta resolução é essencial para observar esses jatos em ação e então revelar fenômenos como as ondas de choque e a turbulência que controla o quanto de luz é produzida num dado tempo. “Combinando pela primeira vez rádio telescópios na Terra com rádio telescópios no espaço, operando na máxima resolução, tem permitido que a nossa equipe crie uma antena que tem um tamanho equivalente a 8 vezes o diâmetro da Terra, correspondendo a 20 micro arcos de segundo”, disse José L; Gómez, o líder da equipe no Instituto de Astrofísica de Andalucía, IAA-CSIC.
PROBING THE SOLAR INTERIOR WITH LENSED GRAVITATIONAL WAVES FROM KNOWN PULSARSSérgio Sacani
When gravitational waves (GWs) from a spinning neutron star arrive from behind the Sun, they are
subjected to gravitational lensing that imprints a frequency-dependent modulation on the waveform.
This modulation traces the projected solar density and gravitational potential along the path as
the Sun passes in front of the neutron star. We calculate how accurately the solar density prole
can be extracted from the lensed GWs using a Fisher analysis. For this purpose, we selected three
promising candidates (the highly spinning pulsars J1022+1001, J1730-2304, and J1745-23) from the
pulsar catalog of the Australia Telescope National Facility. The lensing signature can be measured
with 3 condence when the signal-to-noise ratio (SNR) of the GW detection reaches 100 (f=300Hz)1
over a one-year observation period (where f is the GW frequency). The solar density prole can be
plotted as a function of radius when the SNR improves to & 104.
The characterization of_the_gamma_ray_signal_from_the_central_milk_way_a_comp...Sérgio Sacani
Past studies have identified a spatially extended excess of ∼1-3 GeV gamma rays from the region
surrounding the Galactic Center, consistent with the emission expected from annihilating dark
matter. We revisit and scrutinize this signal with the intention of further constraining its characteristics
and origin. By applying cuts to the Fermi event parameter CTBCORE, we suppress the tails
of the point spread function and generate high resolution gamma-ray maps, enabling us to more
easily separate the various gamma-ray components. Within these maps, we find the GeV excess
to be robust and highly statistically significant, with a spectrum, angular distribution, and overall
normalization that is in good agreement with that predicted by simple annihilating dark matter
models. For example, the signal is very well fit by a 36-51 GeV dark matter particle annihilating to
b
¯b with an annihilation cross section of σv = (1−3)×10−26 cm3
/s (normalized to a local dark matter
density of 0.4 GeV/cm3
). Furthermore, we confirm that the angular distribution of the excess is
approximately spherically symmetric and centered around the dynamical center of the Milky Way
(within ∼0.05◦
of Sgr A∗
), showing no sign of elongation along the Galactic Plane. The signal is
observed to extend to at least ' 10◦
from the Galactic Center, disfavoring the possibility that this
emission originates from millisecond pulsars.
Forming intracluster gas in a galaxy protocluster at a redshift of 2.16Sérgio Sacani
Galaxy clusters are the most massive gravitationally bound structures in the Universe, comprising thousands of galaxies and
pervaded by a diffuse, hot “intracluster medium” (ICM) that dominates the baryonic content of these systems. The formation
and evolution of the ICM across cosmic time1
is thought to be driven by the continuous accretion of matter from the large-scale
filamentary surroundings and dramatic merger events with other clusters or groups. Until now, however, direct observations of
the intracluster gas have been limited only to mature clusters in the latter three-quarters of the history of the Universe, and we
have been lacking a direct view of the hot, thermalized cluster atmosphere at the epoch when the first massive clusters formed.
Here we report the detection (about 6σ) of the thermal Sunyaev-Zeldovich (SZ) effect2
in the direction of a protocluster. In fact,
the SZ signal reveals the ICM thermal energy in a way that is insensitive to cosmological dimming, making it ideal for tracing
the thermal history of cosmic structures3
. This result indicates the presence of a nascent ICM within the Spiderweb protocluster
at redshift z = 2.156, around 10 billion years ago. The amplitude and morphology of the detected signal show that the SZ
effect from the protocluster is lower than expected from dynamical considerations and comparable with that of lower-redshift
group-scale systems, consistent with expectations for a dynamically active progenitor of a local galaxy cluster.
Detection of solar_like_oscillations_in_relies_of_the_milk_way_asteroseismolo...Sérgio Sacani
Asteroseismic constraints on K giants make it possible to infer radii, masses and ages of tens
of thousands of field stars. Tests against independent estimates of these properties are however
scarce, especially in the metal-poor regime. Here, we report the detection of solar-like
oscillations in 8 stars belonging to the red-giant branch and red-horizontal branch of the globular
cluster M4. The detections were made in photometric observations from the K2 Mission
during its Campaign 2. Making use of independent constraints on the distance, we estimate
masses of the 8 stars by utilising different combinations of seismic and non-seismic inputs.
When introducing a correction to the Δν scaling relation as suggested by stellar models, for
RGB stars we find excellent agreement with the expected masses from isochrone fitting, and
with a distance modulus derived using independent methods. The offset with respect to independent
masses is lower, or comparable with, the uncertainties on the average RGB mass
(4 − 10%, depending on the combination of constraints used). Our results lend confidence to
asteroseismic masses in the metal poor regime. We note that a larger sample will be needed
to allow more stringent tests to be made of systematic uncertainties in all the observables
(both seismic and non-seismic), and to explore the properties of RHB stars, and of different
populations in the cluster.
Serendipitous discovery of an extended xray jet without a radio counterpart i...Sérgio Sacani
A recent Chandra observation of the nearby galaxy cluster Abell 585 has led to the discovery of
an extended X-ray jet associated with the high-redshift background quasar B3 0727+409, a luminous
radio source at redshift z = 2:5. This is one of only few examples of high-redshift X-ray jets known
to date. It has a clear extension of about 1200, corresponding to a projected length of 100 kpc, with
a possible hot spot located 3500 from the quasar. The archival high resolution VLA maps surprisingly
reveal no extended jet emission, except for one knot about 1:400 from the quasar. The high X-ray to
radio luminosity ratio for this source appears consistent with the / (1 + z)4 amplication expected
from the inverse Compton radiative model. This serendipitous discovery may signal the existence
of an entire population of similar systems with bright X-ray and faint radio jets at high redshift, a
selection bias which must be accounted for when drawing any conclusions about the redshift evolution
of jet properties and indeed about the cosmological evolution of supermassive black holes and active
galactic nuclei in general.
The canarias einstein_ring_a_newly_discovered_optical_einstein_ringSérgio Sacani
We report the discovery of an optical Einstein Ring in the Sculptor constellation,
IAC J010127-334319, in the vicinity of the Sculptor Dwarf Spheroidal Galaxy. It is
an almost complete ring ( 300◦) with a diameter of 4.5 arcsec. The discovery was
made serendipitously from inspecting Dark Energy Camera (DECam) archive imaging
data. Confirmation of the object nature has been obtained by deriving spectroscopic
redshifts for both components, lens and source, from observations at the 10.4 m Gran
Telescopio CANARIAS (GTC) with the spectrograph OSIRIS. The lens, a massive
early-type galaxy, has a redshift of z = 0.581 while the source is a starburst galaxy
with redshift of z = 1.165. The total enclosed mass that produces the lensing effect
has been estimated to be Mtot = (1.86 ± 0.23) · 1012M⊙.
Similar to Milan Milošević "The shape of Fe Kα line emitted from relativistic accretion disc around AGN black holes" (20)
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
The ASGCT Annual Meeting was packed with exciting progress in the field advan...
Milan Milošević "The shape of Fe Kα line emitted from relativistic accretion disc around AGN black holes"
1. The shape of 𝐹𝑒 𝐾𝛼 line emitted from relativistic
accretion disc around AGN black holes
MILAN MILOŠEVIĆ,
Faculty of Sciences and Mathematics, University of Niš, Serbia
MIIKA A. PURSIAINEN,
Physics and Astronomy, University of Southampton, United Kingdom
PREDRAG JOVANOVIĆ and LUKA Č. POPOVIĆ
Astronomical Observatory, Belgrade, Serbia
SEENET-MTP Balkan Workshop BW2018
10 – 14 June 2018, Niš, Serbia
2. Motivation
𝐹𝑒 𝐾𝛼 line was discovered by Tanaka et al. (1995) in Seyfert 1 galaxy MCG-6-30-15
After its discovery it was observed in a number of active galactic nuclei (AGN);
early results from ASCA – the broad lines could be resonably common in type 1
AGN (~75% of sample, Nandra et al. (1997))
The broad and asymmetric profile of this line with narrow bright “blue” and wide
faint “red” peak is most commonly attributed to the relativistic effects due to a very
fast rotation of the emitting material in the innermost regions of the accretion disk
Recent studies – only about a half of the type 1 AGN at low redshifts have
relativisticly broadened lines
We discuss several phenomena which can induce line shifts, and thus cause the
variability of the profile using a code based on ray-tracing method in the Kerr
metric
3. AGN and SMBH
Active Galactic Nuclei (AGN) – one of the most
energetic sources of radiation
Radiate in all spectral bands from radio to 𝛾-rays;
luminosity ~108
− 1014
𝐿⊙
Power – accretion of matter from the host galaxy
towards a central Supermassive Black Hole (SMBH)
The SMBH is surrounded by a geometrically thin,
optically thick accretion disc which at larger
distances expands into a torus.
4. Classification of Black Holes (BH)
classification according to the metric:
Schwarzschild (non-rotating and uncharged)
Kerr (rotating and uncharged)
Reissner–Nordström (non-rotating and charged)
Kerr–Newman (rotating and charged)
classification according to their masses:
Mini, micro or quantum mechanical: 𝑀 𝐵𝐻 ≪ 𝑀⊙(primordial black holes in the
early universe)
stellar-mass: 𝑀 𝐵𝐻 < 102
𝑀⊙ (in X-ray binary systems)
intermediate-mass: 𝑀 𝐵𝐻 ~ 102
− 105
𝑀⊙ (in the centers of globular clusters)
supermassive: 𝑀 𝐵𝐻 ~ 105
− 1010
𝑀⊙ (in the centers of all galaxies, including ours)
5. AGN and SMBH
The plasma in the accretion disc loses angular
momentum due to viscosity of the plasma forcing the
matter to fall inwards.
The release of gravitational potential energy heats up
the plasma as it keeps flowing towards the black hole,
reaching temperatures of millions of degrees in the
inner parts of the disc.
At these temperatures matter mostly radiates in the X-
ray band.
Unlike in the UV and optical spectra of AGN, in the X-
ray band there are only a few strong emission lines.
Due to the sufficiently high iron abundance in the disc
iron 𝐾𝛼 (6.4-6.9 keV, depending on the ionization
state) is the strongest of them.
Tanaka et al, 1995, Nature, 375, 659
6. AGN and SMBH
The narrow 𝐾𝛼 line from neutral iron (at 6.4 keV) is
present in the spectra of majority of AGN, most
likely originating from more distant colder material
in the outer parts of the disc or the torus for
instance
Same line originating from more inner parts of the
accretion disc, is also very common in the X-ray
spectra of AGN
Broad emission spectral line at 6.4 keV; Dopler
motion and the relativistic effects due to presence
of massive compact object
Asymmetric profile with narrow bright blue peak
and wide faint red peak
Tanaka et al, 1995, Nature, 375, 659
red
blue
7. The 𝐹𝑒 𝐾𝛼 line
Classical Doppler shift: symmetric, double-
peaked profile
Special relativistic transverse Doppler shift
and relativistic beaming: enhance blue peak
relative to red peak
General relativistic gravitational redshift:
smearing blue emission into red:
Fabian, A. C. 2006,
AN, 327, 943
8. Ray-tracing in Kerr metric
In units where
horizon of BH:
radius of marginally stable orbit:
Two approaches:
1. integrating the null geodesic equations starting from a given initial position in the disk
to the observer at infinity
2. tracing rays following the trajectories from the sky plane to the disk (only those photon
trajectories that reach observer's sky plane are considered
9. Simulation
The line emission from the accretion disc
around a SMBH can be analyzed with
numerical simulations based on the ray-
tracing method in the Kerr metric
Only the photon trajectories that reach
the sky plane of the observer
The image of the disk on the observer’s
sky is divided into small pixels
Photon trajectories for each pixel can be
traced backward…
10. Simulation
Photon trajectories for each pixel can be traced
backward
starting from the observer following the
geodesics in the Kerr space-time
The geodesics will cross the plane of the disc
at individual points
For each point the flux density of the disc
radiation and the redshift/blueshift can be
calculated
The simulated line profile can then be calculated
based on the disc images by taking into account
the intensities and received photon energies of all
pixels
11. Ray-tracing method
• Surface emissivity of the disk:
0
( ) qr r =
• Total observed flux:
4
0
( ) ( ) ( ) ,obs obs obs
image
F E r g E gE d = −
• Frequency ratio (energy shift):
12. Simulation
All simulated line profiles are done using the ray-tracing method with an
approach proposed by A. Čadež et al. (1998).
About 60000 accretion disks and corresponding iron 𝐾𝛼 line were
simulated.
Variable parameters:
Emissivity index (𝑞), inclination (𝑖), inner radius (𝑅𝑖𝑛), outer radius (𝑅 𝑜𝑢𝑡), spin of
the BH (a), different number of counts;
Each set of parameters was calculated for different counts of photon and
different bin size.
A. Čadež, C. Fanton, M. Calvani, New Astron. 3 (1998), pp. 647 - 654.
L. Popović, E.G. Mediavilla, P. Jovanović, J.A. Munoz,, A&A 398 (2003), pp. 975 - 982.
L. Popović, P. Jovanović, E. Mediavilla, A.F. Zakharov, C. Abajas, J.A. Munoz, G. Chartas, ApJ 637 (2006), pp. 620 - 630.
P. Jovanović, New Astron. Rev. 56 (2012), pp. 37 - 48.
14. The 𝐹𝑒 𝐾𝛼 line parameters
Asymmetric ratio
Dividing the total flux of line above 6.4
keV by the total flux of the line below
(blue / red)
Full width at half maximum (FWHM) –
in most cases width of the blue peak
25. Conclusion
We developed a model of an accretion disk around a SMBH hole using numerical simulations based
on a ray-tracing method in Kerr metric
This model allows us to study the radiation which originates in vicinity of the SMBHs
The shape of the emitted broad Fe Kα line is strongly affected by three types of shifts:
classical Doppler shift - causing double-peaked profile
special relativistic transverse Doppler shift and relativistic beaming - enhancing blue peak relative to red
one
general relativistic gravitational redshift - smearing blue emission into red one
Comparisons between the modelled and observed iron Kα line profiles allow us to determine the
parameters of the line emitting region as well as to study plasma physics and space-time metrics in
vicinity of SMBHs
Two of them are of especial importance for investigating the strong gravitational field of AGN: mass
of central BH and its angular momentum.
Other parameters can give us information about the plasma conditions in vicinity of the central BH of
AGN.