This document discusses microbial transformation of steroids. It explains that microbes provide enzymes that catalyze transformations like hydroxylation, dehydrogenation, epoxidation, oxidation, and aromatic ring transformations. These transformations can modify steroid structures in regioselective and stereoselective ways. Examples of specific transformations are given, like hydroxylation at carbon-11 of progesterone. The advantages of microbial transformations are their ability to introduce novel enzyme systems and produce heat-stable enzymes. However, low chemical yields can occur if the substrate is toxic to the microbes.