The researchers developed a micro-formulation method to formulate new chemical entities for intravenous injection using only 2-3 mg of the compound. They tested solubility of compounds in various formulation bases using a 50 microliter scale, requiring 100-150 micrograms of compound per test. Results were generally comparable to conventional formulation methods using larger quantities. The micro-formulation approach allows rapid early stage animal screening with minimal compound quantities.