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METABOLISM
Metabolism: FON 241; L. Zienkewicz
Metabolism:
• Metabolism: refers to the entire
network of chemical processes
involved in maintaining life.
• Energy metabolism: the ways that the
body obtains and spends energy from
food.
Metabolism: FON 241; L. Zienkewicz
• Anabolism: The building of compounds from
small molecules into larger ones. Energy is
used for this process to take place.
• Catabolism: The breakdown of molecules
into smaller units. Energy is released in this
process.
– Ex: Glucose catabolism results in the release of
CO2 and H2O
Metabolism: FON 241; L. Zienkewicz
ATP (Adenosine Triphosphate):
• The main energy source of cells.
• Used for muscular contractions,
enzyme activity, etc.
• Catabolism results in the production of
many ATP molecules: energy.
• Used by the body when energy is
needed.
• Hydrolysis breaks the bonds in ATP,
thus releasing energy.
Metabolism: FON 241; L. Zienkewicz
Metabolic Efficiency:
• Food energy is converted to ATP with
approximately 50% efficiency.
• The other 50% is released as heat.
Metabolism: FON 241; L. Zienkewicz
The Cell:
Q: Approximately how many cells does
the human body contain?
A: 1x1014
cells or
100,000,000,000,000. (100 trillion cells)
Metabolism: FON 241; L. Zienkewicz
The Cell:
• The site for metabolic activity.
• Liver cells are the most metabolically
active.
Metabolism: FON 241; L. Zienkewicz
How is energy produced?
Three stages:
1. Proteins, Carbohydrates and Fats are
broken down during digestion and
absorption into smaller units: AAs,
monosaccharides and fatty acids.
2. These smaller compounds are further
broken down into 2-carbon
compounds.
3. Compounds are degraded into CO2
and H20.
Metabolism: FON 241; L. Zienkewicz
Helpers in reactions:
• Enzymes: proteins that facilitate
chemical reactions without being
changed in the process; protein
catalysts.
• Coenzymes: assist enzymes in their
activities.
Metabolism: FON 241; L. Zienkewicz
Breakdown of nutrients for energy:
1. Glucose breakdown
2. Glycerol and Fatty Acid breakdown
3. Amino Acid breakdown
Common Pathway Energy
Fats
Carbohydrates
Protein
Metabolism: FON 241; L. Zienkewicz
1. Glucose breakdown
Glycolysis: A reaction in which glucose is
degraded to pyruvate; net profit: 2 ATP.
An anaerobic pathway.
Glucose
Pyruvate
Lactic Acid Acetyl CoA
Oxygen available
2 ATP
Less oxygen available
Metabolism: FON 241; L. Zienkewicz
The path from Pyruvate to Acetyl CoA is NOT reversible.
Metabolism: FON 241; L. Zienkewicz
Metabolism: FON 241; L. Zienkewicz
2. Glycerol and Fatty Acid breakdown
Triglycerides are broken into:
Glycerol and Fatty Acids (lipolysis).
Glucose
Glycerol
Pyruvate
Fatty acids
Acetyl CoA
Metabolism: FON 241; L. Zienkewicz
3. Amino Acid breakdown
Glucose
Amino Acids
Pyruvate
Amino Acids
Acetyl CoA
Amino Acids
TCA Cycle
Metabolism: FON 241; L. Zienkewicz
3. Amino Acid breakdown (cont.)
• Deamination: AA Keto acid and Ammonia
• Transamination
• Ammonia Urea in the Liver
• Urea excreted via the kidneys
• Water needed for urea excretion
Metabolism: FON 241; L. Zienkewicz
The TCA Cycle:
• Functions to convert Acetyl CoA to CO2
and to produce energy.
• Oxaloacetate combines with Acetyl
CoA to begin the cycle.
• The result: produces potential ATP
(energy).
Metabolism: FON 241; L. Zienkewicz
The Electron Transport Chain:
• The primary site for ATP (energy) synthesis.
• Uses Oxygen to convert products of the TCA
cycle into energy.
Metabolism: FON 241; L. Zienkewicz
Why is fat higher in energy?
•Fat’s carbon-hydrogen bonds can be easily oxidized, yieldin
energy (ATP).
•1 glucose molecule yields 38 ATP when oxidized.
•1 fatty-acid (16-C) will yield 129 ATP when oxidized.

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metabolism-120323035449-phpapp01.pdf

  • 2. Metabolism: FON 241; L. Zienkewicz Metabolism: • Metabolism: refers to the entire network of chemical processes involved in maintaining life. • Energy metabolism: the ways that the body obtains and spends energy from food.
  • 3. Metabolism: FON 241; L. Zienkewicz • Anabolism: The building of compounds from small molecules into larger ones. Energy is used for this process to take place. • Catabolism: The breakdown of molecules into smaller units. Energy is released in this process. – Ex: Glucose catabolism results in the release of CO2 and H2O
  • 4. Metabolism: FON 241; L. Zienkewicz ATP (Adenosine Triphosphate): • The main energy source of cells. • Used for muscular contractions, enzyme activity, etc. • Catabolism results in the production of many ATP molecules: energy. • Used by the body when energy is needed. • Hydrolysis breaks the bonds in ATP, thus releasing energy.
  • 5. Metabolism: FON 241; L. Zienkewicz Metabolic Efficiency: • Food energy is converted to ATP with approximately 50% efficiency. • The other 50% is released as heat.
  • 6. Metabolism: FON 241; L. Zienkewicz The Cell: Q: Approximately how many cells does the human body contain? A: 1x1014 cells or 100,000,000,000,000. (100 trillion cells)
  • 7. Metabolism: FON 241; L. Zienkewicz The Cell: • The site for metabolic activity. • Liver cells are the most metabolically active.
  • 8. Metabolism: FON 241; L. Zienkewicz How is energy produced? Three stages: 1. Proteins, Carbohydrates and Fats are broken down during digestion and absorption into smaller units: AAs, monosaccharides and fatty acids. 2. These smaller compounds are further broken down into 2-carbon compounds. 3. Compounds are degraded into CO2 and H20.
  • 9. Metabolism: FON 241; L. Zienkewicz Helpers in reactions: • Enzymes: proteins that facilitate chemical reactions without being changed in the process; protein catalysts. • Coenzymes: assist enzymes in their activities.
  • 10. Metabolism: FON 241; L. Zienkewicz Breakdown of nutrients for energy: 1. Glucose breakdown 2. Glycerol and Fatty Acid breakdown 3. Amino Acid breakdown Common Pathway Energy Fats Carbohydrates Protein
  • 11. Metabolism: FON 241; L. Zienkewicz 1. Glucose breakdown Glycolysis: A reaction in which glucose is degraded to pyruvate; net profit: 2 ATP. An anaerobic pathway. Glucose Pyruvate Lactic Acid Acetyl CoA Oxygen available 2 ATP Less oxygen available
  • 12. Metabolism: FON 241; L. Zienkewicz The path from Pyruvate to Acetyl CoA is NOT reversible.
  • 13. Metabolism: FON 241; L. Zienkewicz
  • 14. Metabolism: FON 241; L. Zienkewicz 2. Glycerol and Fatty Acid breakdown Triglycerides are broken into: Glycerol and Fatty Acids (lipolysis). Glucose Glycerol Pyruvate Fatty acids Acetyl CoA
  • 15. Metabolism: FON 241; L. Zienkewicz 3. Amino Acid breakdown Glucose Amino Acids Pyruvate Amino Acids Acetyl CoA Amino Acids TCA Cycle
  • 16. Metabolism: FON 241; L. Zienkewicz 3. Amino Acid breakdown (cont.) • Deamination: AA Keto acid and Ammonia • Transamination • Ammonia Urea in the Liver • Urea excreted via the kidneys • Water needed for urea excretion
  • 17. Metabolism: FON 241; L. Zienkewicz The TCA Cycle: • Functions to convert Acetyl CoA to CO2 and to produce energy. • Oxaloacetate combines with Acetyl CoA to begin the cycle. • The result: produces potential ATP (energy).
  • 18. Metabolism: FON 241; L. Zienkewicz The Electron Transport Chain: • The primary site for ATP (energy) synthesis. • Uses Oxygen to convert products of the TCA cycle into energy.
  • 19. Metabolism: FON 241; L. Zienkewicz Why is fat higher in energy? •Fat’s carbon-hydrogen bonds can be easily oxidized, yieldin energy (ATP). •1 glucose molecule yields 38 ATP when oxidized. •1 fatty-acid (16-C) will yield 129 ATP when oxidized.