Mesenchymal stem cells are multipotent adult stem cells found in a variety of organs such as the umbilical cord, bone marrow, and adipose tissue. Mesenchymal stem cells can divide and develop into a variety of tissues, including bone, cartilage, muscle, and fat cells, as well as connective tissue. In this presentation, Dr. David Greene Arizona discusses Mesenchymal Stem Cells & the Blood-Brain Barrier (BBB).

1. Mesenchymal
Stem Cells
Dr. David Greene Arizona

2. Modern studies suggest that
Mesenchymal stem cells (MSCs)
when administered intravenously,
can cross the blood-brain barrier
(BBB) leading to various regenerative
effects
Mesenchymal Stem
Cells & the Blood-Brain
Barrier (BBB)

3. Do mesenchymal
stem cells
administered via IV
cross the blood-
brain barrier (BBB)?
Mesenchymal stem cells (MSCs)
intrinsically possess unique features that
help them migrate towards areas of
inflammation. MSCs secrete various
types of secretomes to induce nerve
regeneration and pain-relieving effects
at inflammatory sites

4. What is the blood-
brain barrier?
The blood-brain barrier (BBB) is a
dispersion barrier, which prevents the
entry of most compounds from the blood
to the brain. According to Ballabh, the
barrier is highly particular, meaning it only
allows certain substances to cross from
the bloodstream into the brain. This
protects the brain from toxins that can
potentially damage neurons

5. Stem cells cross the
blood-brain barrier
in an animal stroke
model
Mesenchymal stem cells represent
a great potential to reverse
neuronal damage associated with
CNS diseases such as Multiple
Sclerosis, Parkinson's disease (PD),
and Alzheimer's disease (AD)

6. What makes mesenchymal
stem cells (MSCs) so special?
Mesenchymal stem cells (MSCs) are an especially attractive
therapeutic agent due to their ease of isolation, established safety, and
potential to target multiple pathways involved in neuronal regeneration.
MSCs are widely used in the treatment of various diseases due to
their self-renewable, differentiation, anti-inflammatory, and
immunomodulatory properties. In-vitro (performed in a laboratory
setting) and in-vivo (taking place in a living organism) studies have
supported the understanding mechanisms, safety, and efficacy of
MSC therapy in clinical applications

7. Homing mechanisms of
mesenchymal stem cells
(MSCs)
One of the key benefits of
mesenchymal stem cells is their ability
to target specific areas of concern due
to their intrinsic homing capabilities.
Mesenchymal stem cell homing, when
administered systemically can be
defined as exiting circulation and
migrating to the injury site

8. Thank You