Mental Status Examination (MSE) is a standardized evaluation of a psychiatric patient's behavior, emotions, and cognitive functions. It involves interviewing the patient and relatives, taking a history, and conducting a physical exam and investigations. The MSE assesses elements like psychomotor activity, speech, mood and affect, thought content and form, perception, cognitive functions, insight, sleep patterns, and orientation. The examiner makes detailed notes of their observations to understand the patient's symptoms and make a clinical diagnosis.