Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma caused by abnormal B-cells that generally accumulate in lymph nodes and can impact other body parts. Diagnosis involves blood tests, biopsies, imaging scans, and bone marrow samples, while treatment options include chemotherapy, radiotherapy, immunotherapy, and stem cell transplantation, though no cure exists for advanced cases. Various agents such as proteasome inhibitors and biological agents like temsirolimus are also considered in managing the disease.

1. MANTLE CELL LYMPHOMA:
PRESENTED BY : Maria Mohammad
Content writer

2. DEFINITION:
 Mantle cell lymphoma (MCL) is a type of
NHL. It develops when B-cells (also called B-
lymphocytes) become abnormal. B-cells are
white blood cells that fight infection.
 The abnormal B-cells (lymphoma cells) usually
build up in lymph nodes, but they can affect
other parts of the body.

3. SYMPTOMS:

4. DIAGNOSIS:
 Blood test
 Biopsy
 x-rays and scans
 bone marrow samples
 Colonoscopy

5. TREATMENT:
 Currently no treatment is available for
advanced MCL.
 Chemotherapy: (e.g : R-CHOP)
 Radiotherapy: Use high energy rays to
destroy cancer cells.
 Immunotherapy: (e.g: Rituximab,
Thalidomide)
 Radioimmunotherapy: (e.g: Zevalin)

6.  Stem cell transplantation
 Proteasome inhibitors
 Other biological agents: ( Temsirolimus)