lysosomes
lysomes
Lysosomes are single membrane bound organelles present in animal
cells.Lysomes have acidic internal pH[about 5] and are filled with
hydrolytic enzymes.They contain about 40 different types of hydrolytic
enzymes[including proteases ,nucleases, glycosidases, lipases,
phospholipases, phosphatases and sulfatases] which are responsible
for digestion of macromolecules. All are acid hydrolases because the
require an acidic environment for optimal activity and the lysosomes
provides thid by maintaining a pH of about 5.
Types of lysosomes
THE ARE TWO TYPES OF LYSOMES:
Lysomes
Primary lysosomes Secondary lysosomes
Primary lysosomes and secondary lysosomes
Primary lysosomes:primary lysosomes are the small vesicles
formed from the Golgi apparatus. Generally, they contain inactive
digestive enzymes in the form of granules.
Secondary lysosomes:Secondary lysosomes are also known as
heterophagosome. They are formed as a result of the fusion of food
containing phagosomes with lysosomes (having digestive or
hydrolytic enzymes). The digested food particles pass out into the
cytoplasm.
Lysosomal digestion of material
Lysosomal digestion of materials can classified as:
➢ Autophagy
➢ hetrophagy
autophagy:A normal physiological process that deals with the destruction of cells in the
body. It is essential for maintaining homeostasis, for normal functioning by protein
degradation, turnover of destroyed cell organelles for new cell formation
hetrophagy:The taking into the cell of exogenous material by phagocytosis or pinocytosis and
the digestion of the ingested material after fusion of the newly formed vacuole with a lysosome.
Lysosomal Enzymes
For degradation of extra and intracellular material, lysosomes filled with enzymes called hydrolases. It contains about
40 varieties of enzymes which are classified into the following main types, namely:
● Proteases, which digest proteins
● Lipases, which digests lipids
● Amylase, which digests carbohydrates
● Nucleases, which digest nucleic acids
● Phosphoric acid monoesters
Collectively the group of enzymes is called hydrolases which cause cleavage of substrates by the addition of water
molecules. Most of the lysosomal enzymes function in the acidic medium.
Why are Lysosomes known as Suicidal Bags?
As stated before, lysosomes work as the waste discarding structures of the cell by
processing undesirable materials and degrading them, both from the exterior of
the cell and waste constituents inside the cell.
But sometimes, the digestive enzymes may end up damaging the lysosomes
themselves, and this can cause the cell to die. This is termed as autolysis, where
“auto” means “self” and “lysis” means “the disintegration of the cell by the
destruction of its cell membrane“.
Hence, lysosomes are known as “Suicidal Bags” of the cell.
lysosomes.pptx

lysosomes.pptx

  • 1.
  • 2.
    lysomes Lysosomes are singlemembrane bound organelles present in animal cells.Lysomes have acidic internal pH[about 5] and are filled with hydrolytic enzymes.They contain about 40 different types of hydrolytic enzymes[including proteases ,nucleases, glycosidases, lipases, phospholipases, phosphatases and sulfatases] which are responsible for digestion of macromolecules. All are acid hydrolases because the require an acidic environment for optimal activity and the lysosomes provides thid by maintaining a pH of about 5.
  • 3.
    Types of lysosomes THEARE TWO TYPES OF LYSOMES: Lysomes Primary lysosomes Secondary lysosomes
  • 4.
    Primary lysosomes andsecondary lysosomes Primary lysosomes:primary lysosomes are the small vesicles formed from the Golgi apparatus. Generally, they contain inactive digestive enzymes in the form of granules. Secondary lysosomes:Secondary lysosomes are also known as heterophagosome. They are formed as a result of the fusion of food containing phagosomes with lysosomes (having digestive or hydrolytic enzymes). The digested food particles pass out into the cytoplasm.
  • 5.
    Lysosomal digestion ofmaterial Lysosomal digestion of materials can classified as: ➢ Autophagy ➢ hetrophagy autophagy:A normal physiological process that deals with the destruction of cells in the body. It is essential for maintaining homeostasis, for normal functioning by protein degradation, turnover of destroyed cell organelles for new cell formation hetrophagy:The taking into the cell of exogenous material by phagocytosis or pinocytosis and the digestion of the ingested material after fusion of the newly formed vacuole with a lysosome.
  • 6.
    Lysosomal Enzymes For degradationof extra and intracellular material, lysosomes filled with enzymes called hydrolases. It contains about 40 varieties of enzymes which are classified into the following main types, namely: ● Proteases, which digest proteins ● Lipases, which digests lipids ● Amylase, which digests carbohydrates ● Nucleases, which digest nucleic acids ● Phosphoric acid monoesters Collectively the group of enzymes is called hydrolases which cause cleavage of substrates by the addition of water molecules. Most of the lysosomal enzymes function in the acidic medium.
  • 7.
    Why are Lysosomesknown as Suicidal Bags? As stated before, lysosomes work as the waste discarding structures of the cell by processing undesirable materials and degrading them, both from the exterior of the cell and waste constituents inside the cell. But sometimes, the digestive enzymes may end up damaging the lysosomes themselves, and this can cause the cell to die. This is termed as autolysis, where “auto” means “self” and “lysis” means “the disintegration of the cell by the destruction of its cell membrane“. Hence, lysosomes are known as “Suicidal Bags” of the cell.