This document outlines the 20 worst mistakes organizations make when implementing Microsoft Configuration Manager (ConfigMgr). Some key mistakes include installing ConfigMgr to the default directory instead of a dedicated volume, not maintaining SQL Server databases, having supplemental server roles like WSUS on the same server as other roles, and not utilizing community tools and resources to continually improve the environment. The top mistake is not following certain ConfigMgr experts on Twitter to stay up to date on best practices and new features.