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Lecture 13   ESS_2nd semester ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Vestibule  - narrow zone in which the epidermis from external surface of the nose is replaced by  nonkeratinized pseudostratified columnar epithelium a round the inner surface of the nares are large  sebaceous and sweat   glands  bound to thick and short hair  called  vibrissae   they  filter out large particles from the inspired air
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],b etween folds the sinus and saccule of the larynx a small slit-like diverticulum of laryngeal cavity is located on each side
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The epiglottis   closes aditus into the larynx basic tissue of the organ is  elastic cartilage i t is covered with a mucous coat: stratified squamous epithelium  is on its lingual aspect  while  pseudostratified columnar epithelium  is on the laryngeal surface t he mucosa contains mixed serous and mucous glands
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Alveolar macrophages:  occur   w ithin the alveoli or in the septa e   cells  are movable and  able  to   phagocyte inspired particles of dust etc. they form a part of phagocyte macrophages system
Blood-air barrier consists of: 1-  respiratory epithelium with surfactant on the surface , 2-  the basal laminae  of closely apposed alveolar and endothelial cells, 3-  endothelial cells  of blood capillaries of continuous type t he total thickness of these layers varies from 0.1 to 1.5   m i nsufficient surfactant production causes difficulty in expanding alveoli and injury of the respiratory epithelium in premature new-borns t he disease  -   respiratory distress syndrome g lucocorticoids stimulate the synthesis of surfactant and are used in treatment of the Respiratory Distress Syndrome (RDS).
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],^ TERMINAL BRONCHIOLES (simple ciliated columnar - cuboidal ep.) 0.5 mm in diameter lamina propria is composed largely of smooth muscle and elastic fibers ^ RESPIRATORY BRONCHIOLES (cuboidal- squamous ep.)<0.3 mm in diameter, wall is interrupted by more or less numerous alveoli where gas exchange occurs smooth muscle and elastic connective tissue lie beneath the epithelium  ^ ALVEOLAR DUCTS is a part of tree whose wall protrude in individual alveoli A.d. open into atria that communicate with alveolar sacs (2 or more of which arise from each atrium ^ ALVEOLAR SACS AND ALVEOLI respiratory ep. with two cell types The bronchial tree
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4. The FOURTH – SIXTH. Cartilage  – cartilages of larynx and trachea. Mesenchyme  – cricothyroid, levator veli palatini, constrictors of pharynx, intrisic muscle from larynx. The 4th aortic arch  – has the ultimate fate different on the left and right sides, On the left it forms a part of the arch of the aorta between the left common carotid artery and the left subclavian vein. On the right side the proximal segment of the right subclavian artery. The 5th aortic arch  -  is transient and soon obliterates.  The 6th aortic arch  – transform into pulmonary artery (their branches) Branchial nerves  – Superior laryngeal branch of the vagus, recurrent laryngeal branch of the vagus.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],periods: Pseudoglandular period  - lung s  somewhat resemble of a  gland , at the end; all major elements of the  organ  have formed except those involved with gas exchange  (respiratory bronchioles and alveoli) e ndoderm cells are cuboidal
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Alveolar period  - is characterized by differentiation of terminal sacs into the future alveolar ducts
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Lecture13 microscopic structure of the respiratory

  • 1.
  • 2.
  • 3.
  • 4.  
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10. The epiglottis closes aditus into the larynx basic tissue of the organ is elastic cartilage i t is covered with a mucous coat: stratified squamous epithelium is on its lingual aspect while pseudostratified columnar epithelium is on the laryngeal surface t he mucosa contains mixed serous and mucous glands
  • 11.
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  • 18.  
  • 19. Alveolar macrophages: occur w ithin the alveoli or in the septa e cells are movable and able to phagocyte inspired particles of dust etc. they form a part of phagocyte macrophages system
  • 20. Blood-air barrier consists of: 1- respiratory epithelium with surfactant on the surface , 2- the basal laminae of closely apposed alveolar and endothelial cells, 3- endothelial cells of blood capillaries of continuous type t he total thickness of these layers varies from 0.1 to 1.5  m i nsufficient surfactant production causes difficulty in expanding alveoli and injury of the respiratory epithelium in premature new-borns t he disease - respiratory distress syndrome g lucocorticoids stimulate the synthesis of surfactant and are used in treatment of the Respiratory Distress Syndrome (RDS).
  • 21.
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  • 24.
  • 25. 4. The FOURTH – SIXTH. Cartilage – cartilages of larynx and trachea. Mesenchyme – cricothyroid, levator veli palatini, constrictors of pharynx, intrisic muscle from larynx. The 4th aortic arch – has the ultimate fate different on the left and right sides, On the left it forms a part of the arch of the aorta between the left common carotid artery and the left subclavian vein. On the right side the proximal segment of the right subclavian artery. The 5th aortic arch - is transient and soon obliterates. The 6th aortic arch – transform into pulmonary artery (their branches) Branchial nerves – Superior laryngeal branch of the vagus, recurrent laryngeal branch of the vagus.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30. Alveolar period - is characterized by differentiation of terminal sacs into the future alveolar ducts
  • 31.
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  • 33.  

Editor's Notes

  1. Nasal Vestibule is the most anterior part of the nasal cavity . It&apos;s enclosed by the cartilages of nose and lined by the same epithelium of the skin (Stratified squamous, keratinized). The other part of the nasal cavity, which is lined by the respiratory epithelium , is called nasal cavity proper . Inside the vestibule are small hairs called vibrissae , which filter dust and other matter that you breath in.
  2. Bowman&apos;s glands (aka olfactory glands, glands of Bowman) are situated in the olfactory mucosa , beneath the olfactory epithelium , in the lamina propria , a connective tissue also containing fibroblasts, blood vessels, and bundles of fine axons from the olfactory neurons. [1] The structure of the Bowman&apos;s glands consists of an acinus in the lamina propria and a secretory duct going out through the olfactory epithelium. Electron microscopy studies show that Bowman&apos;s glands contain cells with large secretory vesicles. [2] Bowman&apos;s glands might secrete proteins such as Lysozyme , amylase and IgA similarly to serous glands . The exact composition of the secretions from Bowman&apos;s glands is unclear, but there is evidence that Bowman&apos;s glands do not produce odorant binding protein . [3]
  3. P seoduglandular period: All major elements of the organ have formed except those involved with gas exchange (respiratory bronchioles and alveoli) A lveolar period C analicular period T erminal sac period