The document discusses the least squares regression method for determining the line of best fit for a dataset. It explains that the least squares method finds the line that minimizes the sum of the squares of the distances between the observed responses in the dataset and the responses predicted by the linear approximation. The document provides steps to calculate the line of best fit, including calculating the slope and y-intercept. It also includes an example of applying the least squares method to find the line of best fit for a dataset relating t-shirt prices and number of t-shirts sold.