The Lean Startup by Eric Ries outlines principles for entrepreneurs to build successful businesses under extreme uncertainty, emphasizing a cycle of validated learning through 'build-measure-learn.' Ries advocates for rapid experimentation and pivots to avoid wasting resources on products that do not meet customer needs, stressing the importance of the minimum viable product (MVP) in achieving early feedback. The document also addresses common myths about lean startups and promotes the use of metrics for informed decision-making.