The document summarizes evaluations from the IARC Monograph Working Group volumes 100 and 101. Some key findings: - Volume 100 assessed hormonal treatments, pharmaceuticals, biological agents, metals/dusts/fibres, and lifestyle factors. It found sufficient evidence that all forms of asbestos, including talc with asbestiform fibers, cause cancers like mesothelioma and lung cancer. - Volume 101 specifically evaluated formaldehyde, occupational exposures as a painter, and maternal exposure to painting before/during pregnancy and childhood leukemia risk in offspring. It confirmed formaldehyde's carcinogenicity and found an increased risk of several cancers from painting occupations.

1. Hormonal treatments assessed by the IARC
Monograph Working Group, Vol. 100, 2009
The Lancet Oncology, volume 10, 13-14, January 2009
A review of human carcinogens—volume 100 Part A:
Pharmaceuticals

2. Antineoplastic drugs, and other
drugs evaluated by the IARC
Monograph Working Group
Vol. 100, 2009
A review of human carcinogens—
Vol. 100 - Part A: Pharmaceuticals
The Lancet Oncology, volume 10, 13-14, January 2009

3. Biological agents assessed by the IARC
Monograph Working Group - Vol. 100, 2009
The Lancet Oncology, volume10, 321-322, April2009
A review of human carcinogens—volume 100 Part B:
Biological Agents

4. Biological agents assessed by the IARC
Monograph Working Group - Vol. 100, 2009
The Lancet Oncology, volume10, 321-322, April2009
A review of human carcinogens—volume 100 Part B:
Biological Agents

5. Metals, arsenic, dusts, and fibres assessed by the IARC
Monograph Working Group Vol. 100, 2009
The Lancet Oncology, volume10, 453-454, May 2009
A review of human carcinogens—volume 100 Part C:
Metals, arsenic, dusts, and fibres

6. ASBESTO:
Crisotilo, Amosite, Crocidolite, Tremolite, Actinolite, Antofillite
EVALUATION
• There is sufficient evidence in humans for the carcinogenicity of all
forms of asbestos.
– Asbestos causes mesothelioma and cancer of the lung, larynx,
and ovary [sufficiente].
– Also positive associations have been observed between
exposure to all forms of asbestos and cancer of the pharynx,
stomach, and colo-rectum [limitato].
• There is sufficient evidence in experimental animals for the
carcinogenicity of all forms of asbestos.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. A Review
of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. Vol.100 C , 2011.
PA Bertazzi, UNIMI

7. Esposizione occupazionale ad amianto e tumore ovarico
Camargo C.M. et al. Env Hlth Perspect. 2011
PA Bertazzi, UNIMI

8. Esposizione occupazionale ad amianto e tumore ovarico
Analisi dei sei studi su alta esposizione
Camargo C.M. et al. Env Health Perspect. 2011
PA Bertazzi, UNIMI

9. Laringe
• The IOM conducted a meta-analysis of cohort studies examining
the association between asbestos exposure and cancer of the
larynx. For studies examining “any” versus no exposure, the
summary relative risk was 1.4 (95%CI: 1.19–1.64).For studies
comparing “high” versus no exposure, the lower bound summary
relative risk was 2.02 (95%CI: 1.64–2.47), and the upper bound
summary relative risk was 2.57 (95%CI:1.47–4.49).
• The IOM also conducted a meta-analysis of the published case–
control studies examining the association between asbestos
exposure and cancer of the larynx (IOM, 2006). This meta-analysis
calculated a summary relative risk of 1.43 (95%CI: 1.15–1.78),
before adjusting for consumption of tobacco and alcohol. After
adjusting for tobacco and alcohol consumption, the association of
cancer of the larynx with asbestos exposure persisted, with an
adjusted summary relative risk of 1.18 (95%CI: 1.01–1.37).
PA Bertazzi, UNIMI

10. ASBESTO:
Crisotilo, Amosite, Crocidolite, Tremolite, Actinolite, Antofillite
EVALUATION
• There is sufficient evidence in humans for the carcinogenicity of all
forms of asbestos.
– Asbestos causes mesothelioma and cancer of the lung, larynx,
and ovary [sufficiente].
– Also positive associations have been observed between
exposure to all forms of asbestos and cancer of the pharynx,
stomach, and colo-rectum [limitato].
• There is sufficient evidence in experimental animals for the
carcinogenicity of all forms of asbestos.
All forms of asbestos are carcinogenic to humans (Group 1).
Talc containing asbestiform fibres is carcinogenic to humans (Group 1)
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. A Review
of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. Vol.100 C , 2011.
PA Bertazzi, UNIMI

11. Esposizione occupazionale ad amianto
e cancro colo-rettale
RR per le categorie di esposizione più alta a confronto con i non esposti
PA Bertazzi, UNIMI IARC Monographs Vol. 100 C, 2012

12. Malattie per le quali Denuncia è Obbligatoria
Lista 1- Elevata probabilità di origine lavorativa-Gruppo 6:
– MM in sede pleurica, pericardica, peritoneale e della tunica vaginale
del testicolo per esposizione ad ‘asbesto’
– MM pleurico per esposizione ad ‘erionite’.
Inoltre
– MM pleurico per esposizione a ‘talco contenente fibre asbestiformi.’
Lista 2 - Limitata probabilità di origine lavorativa - Gruppo 6
– Tumore laringeo per esposizione ad ‘asbesto’
Lista 3 - Possibile origine lavorativa - Gruppo 6
– Tumori gastroenterici per esposizione ad ‘asbesto’
Inoltre
– Mesotelioma pleurico per esposizione a ‘fibre ceramiche’
MINISTERO DEL LAVORO E DELLA PREVIDENZA SOCIALE - DECRETO 14 gennaio 2008
Elenco delle malattie per le quali è obbligatoria la denuncia ai sensi e per gli effetti dell'articolo 139 del testo unico approvato
con decreto del Presidente della Repubblica 30 giugno 1965, n. 1124, e successive modificazioni e integrazioni
SUPPLEMENTO ORDINARIO ALLA GAZZETTA UFFICIALE SERIE GENERALE N. 70 22.3.2008
PA Bertazzi, UNIMI

13. Nuova Tabella Malattie Professionali
Figurano nella Nuova Tabella delle Malattie Professionali
nell’Industria:
– MM insorto in sede pleurica, pericardica, peritoneale e della
tunica vaginale del testicolo a causa di ‘Lavorazioni che
espongano all’azione di fibre di asbesto’
– MM pleurico e peritoneale insorto a causa di ‘Estrazione e
utilizzazione di erionite’.
MINISTERO DEL LAVORO E DELLA PREVIDENZA SOCIALE - DECRETO 14 Gennaio 2008
Nuove Tabelle delle Malattie professionali nell’Idustria e nell’Agricoltura
SUPPLEMENTO ORDINARIO ALLA GAZZETTA UFFICIALE SERIE GENERALE N. 169 21.7.2008
PA Bertazzi, UNIMI

14. Chemical agents and related occupations assessed by the IARC
Monograph Working Group Vol. 100, 2009
The Lancet Oncology,vol.10, 751-752, August 2009
A review of human carcinogens—volume 100 Part D:
Radiation

15. Chemical agents and related occupations assessed by the IARC
Monograph Working Group Vol. 100, 2009
The Lancet Oncology,vol.10, 1033-1034, November 2009
A review of human carcinogens—volume 100 Part E:
Lifestyle factors

16. • Aflatoxins, • Soot, as found in occupational exposure of
chimney-sweeps,
• 4-Aminobiphenyl,
• Coal gasification,
• Benzene,
• Occupational exposures during coal-tar
• Benzidine, distillation,
• Dyes metabolized to benzidine, • Coke production,
• Bis(chloromethyl)ether & chloromethyl • Coal-tar pitch,
methyl ether (technical grade), • Untreated or mildly treated mineral oils,
• 1,3-Butadiene, • Shale oils
• Ethylene oxide, • Occupational exposures during aluminum
production,
• Formaldehyde,
• Auramine production,
• 4,4′-methylenebis(2-chloroaniline), • Occupational exposures during iron and steel
• Mustard gas, founding,
• 2-Naphthylamine, • Isopropyl alcohol manufacture by the strong-
acid process,
• 2,3,7,8-TCDD,
• Magenta production, Occupational exposure
• 2,3,4,7,8-PeCDF, as a painter,
• PCB 126, • Occupational exposures in the rubber
• o-Toluidine, manufacturing industry,
• Vinyl chloride, • Mists from strong inorganic acids were found
to be carcinogenic to humans (Group1).
• Benzo[a]pyrene,
Auramine and magenta were found to be possibly carcinogenic to humans (Group 2B).

17. Chemical agents and
related occupations
assessed by the IARC
Monograph Working
Group Vol. 100, 2009
A review of human
carcinogens—volume
100 Part F:
Chemical agents and
related occupations

18. Chemical agents and related occupations assessed by the IARC
Monograph Working Group Vol. 100, 2009
A review of human carcinogens—volume 100 Part F:
Chemical agents and related occupations

19. A review of human carcinogens - Part F:
Chemical agents and related occupations
• Formaldehyde was confirmed as • Occupational exposure as a painter
carcinogenic to humans. There is causes cancers of the lung, urinary
sufficient evidence in humans of an bladder and pleural mesothelioma
increased incidence of nasopharyngeal in humans. Due to the diversity and
carcinomas. In addition, the complexity of the exposures, it is
epidemiological evidence on leukemia difficult to identify causal agents or
has become stronger, and new a causal mechanism, although there
mechanistic studies support a is strong evidence that the
conclusion of sufficient evidence in exposures are genotoxic. The
humans. This highlights the value of Working Group found limited
mechanistic studies, which in only 5 evidence of an association between
years have replaced previous maternal exposure to painting
assertions of biological implausibility before and during pregnancy and an
with new evidence that formaldehyde increased risk of childhood leukemia
can cause blood-cell abnormalities in the offspring. These findings
that are characteristic of leukemia confirm those of a previous Working
development. Group (2007).

20. IARC Monograph Working Group Vol. 101, 2011
The Lancet Oncology, Volume 12, 328-329, April 2011