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Compound                                      I-TEF* (NATO-CCMS)   WHO 1998   WHO 2005
Polychlorinated-dibenzo-para-dioxins (PCDD)
2,3,7,8-TCDD                                          1                1          1
1,2,3,7,8-PentaCDD                                   0.5               1          1
1,2,3,4,7,8-HexaCDD                                  0.1              0.1        0.1
1,2,3,6,7,8-HexaCDD                                  0.1              0.1        0.1
1,2,3,7,8,9-HexaCDD                                  0.1              0.1        0.1
1,2,3,4,6,7,8-HeptaCDD                               0.01            0.01       0.01
OCDD                                                0.001           0.0001     0.0003
Polychlorinated dibenzofurans (PCDF)
2,3,7,8-TCDF                                         0.1              0.1        0.1
1,2,3,7,8-PentaCDF                                   0.05            0.05       0.03
2,3,4,7,8-PentaCDF                                   0.5              0.5        0.3
1,2,3,4,7,8-HexaCDF                                  0.1              0.1        0.1
1,2,3,6,7,8-HexaCDF                                  0.1              0.1        0.1
1,2,3,7,8,9-HexaCDF                                  0.1              0.1        0.1
2,3,4,6,7,8-HexaCDF                                  0.1              0.1        0.1
1,2,3,4,6,7,8-HeptaCDF                               0.01            0.01       0.01
1,2,3,4,7,8,9-HeptaCDF                               0.01            0.01       0.01
OCDF                                                0.001           0.0001     0.0003
Non-ortho-PCBs (nPCB)
3,3’,4,4’-TCB (PCB 77)                              0.0005          0.0001     0.0001
3,4,4’,5-TCB (PCB 81)                                  -            0.0001     0.0003
3,3’,4,4’,5-PentaCB (PCB 126)                         0.1             0.1        0.1
3,3’,4,4’,5,5’-HexaCB (PCB 169)                      0.01            0.01       0.03
Mono-ortho-PCBs (mPCB)
2,3,3’,4,4’-PentaCB (PCB 105)                       0.0001          0.0001     0.00003
2,3,4,4’,5-PentaCB (PCB 114)                        0.0005          0.0005     0.00003
2,3’,4,4’,5-PentaCB (PCB 118)                       0.0001          0.0001     0.00003
2’,3,4,4’,5-PentaCB (PCB 123)                       0.0001          0.0001     0.00003
2,3,3’,4,4’,5-HexaCB (PCB 156)                      0.0005          0.0005     0.00003
2,3,3’,4,4’,5’-HexaCB (PCB 157)                     0.0005          0.0005     0.00003
2,3’,4,4’,5,5’-HexaCB (PCB 167)                    0.00001          0.00001    0.00003
2,3,3’,4,4’,5,5’-HeptaCB (PCB 189)                  0.0001          0.0001     0.00003
Di-ortho-PCBs (dPCB)
2,2’,3,3’,4,4’,5-HeptaCB (PCB 170)                  0.0001             -          -
2,2’,3,4,4’,5,5’-HeptaCB (PCB 180)                 0.00001             -          -
• Many of the effects of 2,3,7,8-TCDD are modulated
  by the Ah receptor (AhR). Several related
  compounds share the capacity of binding to AhR
  (hence the term “dioxin-like”) and may therefore
  have similar effects. Currently, they include seven
  2,3,7,8-substituted PCDDs, ten 2,3,7,8-substituted
  PCDFs, four non-ortho-PCBs (nPCBs), and eight
  monoortho-PCBs (mPCBs).
• Significant decreases over time (1985–2008) were
  documented for PCCDs, PCDFs, and TEQs including
  their contributions.
• No significant decrease was found for non-ortho-
  PCBs, notably PCB 126.

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Dioxin like

  • 1. Compound I-TEF* (NATO-CCMS) WHO 1998 WHO 2005 Polychlorinated-dibenzo-para-dioxins (PCDD) 2,3,7,8-TCDD 1 1 1 1,2,3,7,8-PentaCDD 0.5 1 1 1,2,3,4,7,8-HexaCDD 0.1 0.1 0.1 1,2,3,6,7,8-HexaCDD 0.1 0.1 0.1 1,2,3,7,8,9-HexaCDD 0.1 0.1 0.1 1,2,3,4,6,7,8-HeptaCDD 0.01 0.01 0.01 OCDD 0.001 0.0001 0.0003 Polychlorinated dibenzofurans (PCDF) 2,3,7,8-TCDF 0.1 0.1 0.1 1,2,3,7,8-PentaCDF 0.05 0.05 0.03 2,3,4,7,8-PentaCDF 0.5 0.5 0.3 1,2,3,4,7,8-HexaCDF 0.1 0.1 0.1 1,2,3,6,7,8-HexaCDF 0.1 0.1 0.1 1,2,3,7,8,9-HexaCDF 0.1 0.1 0.1 2,3,4,6,7,8-HexaCDF 0.1 0.1 0.1 1,2,3,4,6,7,8-HeptaCDF 0.01 0.01 0.01 1,2,3,4,7,8,9-HeptaCDF 0.01 0.01 0.01 OCDF 0.001 0.0001 0.0003 Non-ortho-PCBs (nPCB) 3,3’,4,4’-TCB (PCB 77) 0.0005 0.0001 0.0001 3,4,4’,5-TCB (PCB 81) - 0.0001 0.0003 3,3’,4,4’,5-PentaCB (PCB 126) 0.1 0.1 0.1 3,3’,4,4’,5,5’-HexaCB (PCB 169) 0.01 0.01 0.03 Mono-ortho-PCBs (mPCB) 2,3,3’,4,4’-PentaCB (PCB 105) 0.0001 0.0001 0.00003 2,3,4,4’,5-PentaCB (PCB 114) 0.0005 0.0005 0.00003 2,3’,4,4’,5-PentaCB (PCB 118) 0.0001 0.0001 0.00003 2’,3,4,4’,5-PentaCB (PCB 123) 0.0001 0.0001 0.00003 2,3,3’,4,4’,5-HexaCB (PCB 156) 0.0005 0.0005 0.00003 2,3,3’,4,4’,5’-HexaCB (PCB 157) 0.0005 0.0005 0.00003 2,3’,4,4’,5,5’-HexaCB (PCB 167) 0.00001 0.00001 0.00003 2,3,3’,4,4’,5,5’-HeptaCB (PCB 189) 0.0001 0.0001 0.00003 Di-ortho-PCBs (dPCB) 2,2’,3,3’,4,4’,5-HeptaCB (PCB 170) 0.0001 - - 2,2’,3,4,4’,5,5’-HeptaCB (PCB 180) 0.00001 - -
  • 2. • Many of the effects of 2,3,7,8-TCDD are modulated by the Ah receptor (AhR). Several related compounds share the capacity of binding to AhR (hence the term “dioxin-like”) and may therefore have similar effects. Currently, they include seven 2,3,7,8-substituted PCDDs, ten 2,3,7,8-substituted PCDFs, four non-ortho-PCBs (nPCBs), and eight monoortho-PCBs (mPCBs). • Significant decreases over time (1985–2008) were documented for PCCDs, PCDFs, and TEQs including their contributions. • No significant decrease was found for non-ortho- PCBs, notably PCB 126.