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Histology of the Urinary System
Lab Orientation
DC
T
PCT
(Papillary
Duct)
Renal
Corpuscle
Minor
Key Features of the Kidney
(from Dr. Carbreyโ€™s notes)
Kidney โ€“ surrounded by CT capsule, no mesothelium
Cortex - alternating medullary rays (CDs & straight tubules) and
cortical labyrinths (renal corpuscles, conv. tubules)
can distinguish histologically: renal corpuscles , PCT, DCT, CD
renal corpuscles โ€“ glomerulus and Bowmanโ€™s capsule
glomerulus โ€“ capillaries
Bowmanโ€™s capsule โ€“ double-layered epithelial
structure that surrounds glomerulus
Medulla - medullary pyramids bordered by renal columns
can see histologically: loop of Henle, thick asc. limb, CD, vasa recta
papillae with the area cribosa and ducts of Bellini (s.
col. CD) projecting into the calyx (transitional epi)
Histology of Tubules:
PCT โ€“ s. cub., microvilli and basal striations, dark staining, few nuclei
in sections of cells, stellate or occluded lumen, most
numerous tubule in cortex, cortex only
DCT โ€“ s. cub., less microvilli, more nuclei in section, pale staining,
usually has an open lumen, cortex only
CD โ€“ s.cub., no microvilli or basal striations, clear cell boundaries,
nucleus in most sections of cells
thin segments of the loop of Henle โ€“ s. sq. with rounder nuclei than
vasa recta, medulla only
Thick asc. limb โ€“ s. cub., not every section of cell has nucleus, no clear
cell boundaries
Slide 40: kidney
CORTEX
MEDULLA
C
M
P
DCT
DCT
PCT
PCT
PCT
PCT
PCT
PCT
G
Slide 40: kidney
corte
x
medulla
papilla
perirenal fat
(what type?)
calyx
Slide 49: kidney (cortex)
pct
pct
pct
dct
dct
dct
dct
art
glomerulus
medullary ray cortical labyrinth
pt cap
Slide 49: kidney (medulla)
cd
atl
tl
tl
Slide 304: kidney, PAS
medulla
p
p
d
d
Slide 304: kidney, PAS, cortical section: medullary rays will appear as fascicles (like bundles of straws) amidst cortical
labyrinth of coiled tubes and glomeruli
itla
itlv
Slide 55: ureter
lumen
lp
lm
lm
lm
cm
epithelial lining of ureter
Key Features of the Ureter
(from Dr. Carbreyโ€™s notes)
โ€ข small lumen to wall thickness ratio compared
to bladder
โ€ข mucosa - transitional epithelium lines a star-
shaped lumen, lam. prop.
โ€ข muscularis - 2 layers of sm. muscle โ€“ inner
long., outer circum. (opposite of GI)
โ€ข last 1/3 of ureter gains a 3rd layer of s. muscle
like bladder
โ€ข adventitia
Ductus Deferens
โ€ข transitional epith.
โ€ข i.l. / o.c. muscle (+o.l. m near bladder)
โ€ข pseudostrat. col. epith.
โ€ข i.l. / m.c. / o.l. muscle
Ureter
Slide 98: bladder
muscularis
lamina propria
serosa
Key Features of the Bladder
(from Dr. Carbreyโ€™s notes)
โ€ข large lumen to wall thickness ratio compared to
ureter
โ€ข mucosa - transitional epithelium and lamina
propria
โ€ข muscularis - 3 layers of smooth muscle โ€“
inner longitudinal, middle circular,
outer longitudinal
โ€ข mostly adventitia (where against body wall) but
some serosa (where projecting into pelvic cavity)
โ€˜Extraโ€™ slides
Medullary
Pyramid
Cortex
Minor Calyx of
the Renal Pelvis
(Straight
Tubules)
(Convoluted Tubules
+ Medulary Rays)
Vasa
Recta
Artifacts
(Tissue Folds)
Cortico-Medullary
Junction
Papilla
(TIP OF Pyramid)
Slide 204โ€”Human Kidney
Bowmanโ€™s Capsule:
glomerulus
(Parietal Layer)
dct
Vascular
Urinary Pole
(Visceral Layer =
Podocytes)
Renal Corpuscle:
(Urinary Space)
Slide 204 - Cortical Labyrinth
dct
dct
pct
pct
pct
Cortical
Labyrinth
Medullary
Ray
Renal
Corpuscle
PCT
CT
Slide 204
Cortico-
Medullary
Junction
Medullary
Ray
Interlobular
Artery
Interlobular
Vein
Arcuate Artery
Arcuate
Vein
Vasa Recta
Lobule
Slide 204 โ€“ blood supply
Cortex Medulla
Kidney Lobule
Medulla
Cortex
Slide 210-
Monkey Kidney
Cortico-Medullary
Junction
glomeruli
bb
bm
md
DCT
Slide 210 - PAS Stain
DCT
PCT
PCT
Lobe
Minor Calyx
Papilla of
Medullary
Pyramid
Interlobar
Artery and Vein
Arcuate Artery
(and Vein)
Slide 206 โ€“ fetal kidney (lobular)

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Lab16-UrinarySystemOrientation.pptx