Antibodies, also known as immunoglobulins, are Y-shaped proteins produced by plasma cells that recognize and bind to specific antigens to help eliminate pathogens. They are extremely heterogeneous and are composed of repeating immunoglobulin domains containing variable and constant regions that give antibodies their unique antigen binding abilities. Antibodies exist in different classes called isotypes that have distinct effector functions such as activating the complement system or recruiting other immune cells. The binding of an antibody to an antigen is highly specific, occurring where the antigen's epitope, or antigenic determinant, interacts with the antibody's antigen binding site in a complementary manner.
What is an Antibody?Immunoglobulins: Classes and Sub classesvarinder kumar
Forms
History
Immunoglobulins: Classes and Sub classes
Epitope
Antibodies structure
Antibody–antigen interactions
Function
Medical Applications
Regulations
Preclinical studies
Structure prediction
Antibody mimetic
What is an Antibody?Immunoglobulins: Classes and Sub classesvarinder kumar
Forms
History
Immunoglobulins: Classes and Sub classes
Epitope
Antibodies structure
Antibody–antigen interactions
Function
Medical Applications
Regulations
Preclinical studies
Structure prediction
Antibody mimetic
antibodies are a large proteins. based on electrophorosis and centrifugation anti bodies are mainly five types .these are protects on human body from various microorganisms.
i am discuss about ,
1] INTRODUCTION OF ANTIBODIES
2] HISTORY OF ANTIBODIES
3] STRUCTURE OF ANTIBODIES
4] IMMUNOGLOBULIN DOMAINS
5] HEAVY CHAIN
6] LIGHT CHAIN
7] CLASSES OF ANTIBODIES
& ITS FUNCTIONS.
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An antigen is any substance that causes your immune system to produce antibodies against it. This means your immune system does not recognize the substance, and is trying to fight it off. An antigen may be a substance from th
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antibodies are a large proteins. based on electrophorosis and centrifugation anti bodies are mainly five types .these are protects on human body from various microorganisms.
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Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through
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2. antigen
• Antibody: a protein (immunoglobulin) that binds an antigen.
• Antigen: a substance that is recognized by the immune system
• Immunogen: a substance that elicits an immune response (not all
antigens are immunogenic!)
• Epitope: the portion of an
antigen that is recognized by the
antibody (or TCR). Also called
“antigenic determinant”
• Hapten: a small molecule that
cannot by itself induce an
immune response, but can be an
antigen.
Definitions
4. Antibody molecules
are composed of
repeats of a single
structural unit known
as the
“immunoglobulin
domain”
When the amino acid sequences of several different Bence-Jones proteins
were compared, they were found to consist of two repeating units of ~110
amino acids: one variable and one constant.
Ig Structure
6. All Ig domains have a
similar 3D structure
known as an
“Immunoglobulin Fold”.
2 b-pleated sheets come
together to form a
sandwich, held together
by disulfide bond and
hydrophobic interactions.
3 flexible loops at end:
correspond to
hypervariable regions of
primary sequence (HV).
Ig Structure
11. B cell epitopes can be sequential (linear) or non
sequential (conformational)
Five sequential epitopes
in whale myoglobin
A non-sequential epitope
in hen lysozyme
13. Ig isotypes are due to differences in heavy-chain or light-chain constant
region sequences.
Heavy chains come in 5 major types that have different tissue
distributions and effector functions : g, m, d, a, e
Light chains come in two major types: k or l
Ig TYPES
15. Antibodies protect by recruiting other effector functions through the
interaction of CH domains with other cells and proteins of the
immune system.
Different antibody isotypes recruit different effector functions.
Receptors that bind to the Fc portion of antibodies are called
“Fc receptors”.
Ig Effector Functions
24. Toxins bind to
Cellular receptor
Endocytosis of
Toxin-receptor
Complex
Dissociation of
toxin
to release active
chain which
poisons cell
Antibody
protects cell by
blocking
binding of toxin
Neutralization
25. Free Ig binds poorly
to Fc receptors
Aggregation of Ig on bacterial
surface promotes aggregation
of Fc receptors
No activation of macrophage,
No destruction of bacterium
Activation of macrophage
leading to
destruction of bacterium
26. Antibody binds
antigens on the
surface of target cells
Fc receptors on
NK cells recognize
bound antibody
Cross-linking of Fc
receptors signals the
NK cell to kill
the target cell
Target cell dies by
apoptosis and
membrane damage
Antibody-Dependent Cellular Toxicity
(ADCC)
34. Immunogenicity
• Foreignness-- greater difference from host
• Size-- bigger is better
• Complexity- polyglycine is a poor immunogen
• Susceptibility to phagocytosis- particles better than soluble
material
• Genotype of host- MHC types
• Route of administration subcu better than IV
• Dose - not too high, not too low
35. -triggering the innate immune system (many contain TLR agonists)
-slowing release of antigen
-promoting phagocytosis of antigen, others?
Adjuvants enhance the immunogenicity of antigens by:
The first adjuvant Freund’s complete adjuvant: emulsified mineral oil and
mycobacterial extract.
The most effective adjuvants cannot be used in humans due to toxcity (exception:
diptheria-pertussis-tetanus combined vaccine (DPT))
36. Hapten: a small molecule that cannot by itself induce an
immune response, but can be an antigen.
NO2
NO2
DNP-- 1,3 Dinitrophenol
NO2
NO2
DNP-- 1,2 Dinitrophenol
Even closely related haptens can be distinguished antigenically;
antibodies raised against 1,2 DNP may not react with 1,3 DNP.
Haptens