The document outlines key messages about chronic IBS (C-IBS) to communicate to doctors. It notes that C-IBS patients predominantly experience abdominal pain, bloating, and constipation, which fluctuate and decrease quality of life. It emphasizes that IBS significantly impacts quality of life, is highly prevalent and costly, and is a serious condition requiring treatment to improve patients' quality of life. Finally, it positions Zelmac as the only treatment that addresses the underlying cause of C-IBS by working in three ways to provide rapid and sustained relief of multiple C-IBS symptoms.

1. Key Messages we are communicating
The predominant symptoms of a C-IBS patient are abdominal pain,
bloating and constipation. These symptoms wax and wane and
affect all aspects of her life, leading to decreased quality of life.
Desired outcome:
 Bring to the doctor’s mind the disease area and the
patient group he sees and their symptoms

2. Key Messages: Disease related
 The impact of IBS is high as it is a prevalent condition
which takes up much of the doctors consultation time,
and the cost of IBS is measured in monetary terms as
well as an impact of the patients quality of life.
 Desired outcome:
Make IBS matter- it is not a non- disease it affects lives

3. Key Message: Disease /Patient related
 The impact of IBS on QOL versus other common
chronic episodic ondition is often worse than the other
conditions. It is therefore vital that the IBS patients are
treated, so that their QOL can be improved.
 Desired outcome:
 You have circumstances- to create a story ..
 Emphasize that IBS affects lives

4. Key Message: Patient related
 IBS has a serious impact on patient’s daily activities
and QOL.
 Desired outcome:
 Make it serious- bring to the treating physician the
urgency to treat patients

5. Key Message: Patient related
 C-IBS patients report a high incidence of abdominal
pain, bloating and constipation as their predominant
symptoms.
 Desired outcome:
 re-iterate to the doctor that the patient could use other
terms for describing that she is bloated or has
constipation. This again highlights the importance of
the doctor asking questions and discussing her
symptoms with her.

6. Key Message: Product Related
 Traditional therapies do not meet the need and only
treat individual symptoms. The traditional therapies
also exacerbate other symptoms and do not address
the underlying cause of C-IBS

7. Key Message: Product Related
 Zelmac is the only treatment that provides
multisymptom relief of C-IBS by working in 3 ways to
address the underlying cause

8. Key Message: Product Related
 Zelmac is the only treatment available that meets all 3
criteria and provides multisymptom relief of C-IBS.

9. Key Message: Product Related
 Zelmac provides rapid and sustained multisymptom
relief of the symptoms with C-IBS

10. Key Message: Product Related
 Zelmac provides rapid and sustained multisymptom
relief of the symptoms with C-IBS