Juan-Rodriguez-SCIA-AutismOne-2013 (1)

2013
Microglial Activation
in Autism
Closer Than Ever To Finding A Cure
Microglia – The brain's
immune system
cell behind autism.
www.stopcallingitautism.org www.stopcallingitautism.orgespanol
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Agenda
• Video: Daniel’s journey through autism
• What is autism
• The role of microglial activation in autism
• How to block microglial activation In autism
• Making treatments that block microglial
activation available at your local pharmacy
• Tips To Prevent Autism
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Who is Juan Rodriguez?
• Born in Mayaguez, Puerto Rico
• Happily married with Sandra Rodriguez
• Three sons, Daniel (8yrs), Adrian (7yrs) and Lucas (20mos)
• Became a medical researcher while seeking help for his son Daniel
• Founder and President of Stop Calling it Autism!
• Founder of Glial Technologies LLC www.glialtechnologies.com
• Author of a medical article that provides an end to end explanation of
the autism disease process
• Discovered a medical treatment that blocks microglial activation in
autism
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Daniel’s Story
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Daniel before autism Daniel with autism Daniel – cured from autism

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Video of Daniel’s journey
through autism
Link to Video

Autism According to the CDC
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The Center for Disease Control and Prevention (CDC)
provides the following facts in regards to autism
Definition
• Autism is developmental disorder that can cause significant social,
communication and behavioral challenges.
Diagnosis
• Autism can be very difficult to diagnose since there is no medical test,
like a blood test, to diagnose the disorders. Doctors look at the child’s
behavior and development to make a diagnosis.
Causes
• We do not know all of the causes of autism.
Treatment
• There is currently no cure for autism.
CDC – “There is currently
no cure for ASDs and we
do not know all the causes
of ASDs.”
Logo courtesy of the Center for Disease
Control and Prevention (CDC)

Autism Statistics in the
United States
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The incidence of autism continues
to grow at a very alarming rate.
Graph courtesy of Autism Speaks
Based on Data from February 2007
• Autism affects 1 in 150 children
(1 in 110 in 2009, 1 in 88 in 2011
and now 1 in 50 children are now
affected in 2013!
• Annual cost in the United States is
90 billion dollars (90% of the cost
for adult care and services)
• It is the fastest growing
developmental disorder in the USA
• In 10 years (2017), the annual cost
of autism will be $200-400 billion

Autism According to SCIA
8
Stop Calling It Autism! (SCIA) provides the following facts in
regards to autism
Definition
• A medical illness in which the brain’s immune system (microglia) attack the
connections in the brain. This leads to developmental delays that can cause
significant social, communication and behavioral problems
• Children with autism often suffer from many other medical illnesses that are
associated with microglial activation.
Diagnosis
• Autism can be diagnosed with blood tests that are commonly used by doctors to
diagnose infections, inflammation and immune system dysfunction
• Brain SPECT scans can also be used to determine the areas of the brain affected
by microglial activation
Cause
• Autism is caused by microglial activation.
Treatment
• Medications that can block microglial activation and keep infections under
control.
Autism can be diagnosed with blood
tests and brain SPECT scans.

The New Frontier in
Brain Science
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• Everything that is known and said about autism and other
mental illnesses is rapidly changing as we speak
• Through the understanding of the role of the microglia in
health and disease, many mental conditions including autism
can be cured
• Many world renown scientists are now beginning to
understand how important this new science is
• Daniel was the first child to be completely cured from autism
by following the science that will be explained in this
presentation.
• Many children are now following Daniel’s footsteps.
immune system
cell behind autism.

Glial Research Is Growing
Very Quickly
10
DOAJ – Directory of Open Access Journals

The Function of the Glial Cells
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What are glial cells?
• Most common cells in the central nervous
system (CNS)
• They provide support and protection for the
neurons in the brain
• Control communication between neurons
• Control blood flow in the brain
• There are three types of glial cells: astrocytes,
oligodendrocytes and the microglia
Types and functions of the glial cells
• Microglia – brain’s immune system cells, they
are in charge of neurotransmission
• Astrocytes – in charge of neurotransmission
(similar to the microglia) and they also
provide metabolic support to the neurons
• Oligodendrocytes – produce myelin which
acts like an electrical wire insulation in the
neurons
Image Courtesy of “N. Allen and B. Barres, 2009”
The microglia and the other glial cells play a central role in brain function

The role of microglial cells in
normal brain development
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Microglial Cells are essential in
brain development
• Microglial are not only are our brain’s
immune system cells
• They influence synaptic development
and connectivity.
• They regulate brain development by
microglia do the trimming of the extra
synapses
Image Courtesy of “Kettenmann and Kirchhoff, 2013”
Microglial cells are not only our brain’s immune system cells, but also are essential
in the normal and developing brain. They influence synaptic development and
connectivity.
The figure above shows the dynamic interaction of microglial processes with the tripartite synapse(A) Microglial
processes (red) dynamically contact the cellular compartments of the tripartite synapse: pre- and postsynaptic
neuronal terminals (in brown) as well as the enwrapping perisynaptic astroglial process (in blue).(B) The electron
micrograph (EM) specifically shows a microglial process (m) contacting both the pre- and postsynaptic compartment.

Microglial Activation Leads to
Brain Dysfunction In Autism
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Microglial cells when activated
wrap too many brain connections
and destroy them.
When the microglial cells become chronically activated they destroy too many
brain connections. In autism this leads to brain underconnectivity and dysfunction.
The figure above shows the synaptic pruning by microglial processes. (A) The stability and maintenance of
presynaptic terminals and postsynaptic spines is determined by microglia in a three-step process called synaptic
pruning composed of contact, engulfment, and phagocytosis of presynaptic terminals. (B) The electron
microphotograph shows ultrastructural interactions between microglia (red) and synapses (brown) in the mouse
visual cortex.
Image Courtesy of “Kettenmann and Kirchhoff, 2013”

Microglial Activation In Autism
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Microglial Activation is at the center
stage of all common neurological and
medical problems in autism.
From speech and behavioral
disorders to ezcema, food allergies,
GI issues, frequent infections, seizure
activity, sensorial problems to eating
disorders.
Microglia – The brain's immune
system cell behind autism.

Role of glial cells in the gut issues
in autism
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Many individuals with autism often suffer from GI issues
including food allergies, constipation, diarrhea, intestinal
bowel disease (IBD), irritable bowel syndrome (IBS), etc…
Often referred to as the “second brain”, the enteric nervous
system (ENS) controls the function of the digestive tract.
The enteric nervous system can operate independently
from the brain
Similar to the neurons found in the brain, the neurons in the
enteric nervous system, are surrounded by glial cells.
Glial cells in the central nervous system (CNS) can
communicate with the glial cells in the enteric nervous
system (ENS)
The enteric nervous system is
composed of both neurons and glia.
Recent evidence indicates that enteric
glia–which vastly outnumber enteric
neurons–are actively involved in the
control of gastrointestinal
functions
The role of enteric glia
in gut inflammation
Glial cells in the gut

Role of glial cells in the gut issues
in autism
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The glial cells in the digestive system are known as enteric
glial cells (EGCs)
EGCs can be both protective and destructive in the gut
EGCs have an important role in maintaining the integrity of
the mucosal barrier of the gut
EGCs are involved in basic gut functions, such as the
regulation of peristalsis, blood flow and the modulation of
the immune and inflammatory processes
In autism, glial cells in both the brain and in the digestive
system don’t work correctly causing the neuron
underconnectivity that leads to the neurological and GI
symptoms
Peristalsis
Enteric Glial Cells
The glial cells in the digestive
systems are known as enteric
glial cells
Peristalsis are a series of
muscle contractions that
occur in your digestive tract

Are children with autism different?
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Children with autism suffer from different neurological and medical
problems, but the root cause is the same… Microglial Activation
• Seizures - Microglial activation exacerbates seizure activity
• Motor Skills Disorders - is a result of weak or disorganized
connections in the brain.
• Mitochondrial Disorder – Elevated levels of nitric oxide (NO)
inhibits mitochondrial respiration of surrounding neurons
• Frequent Viral, Fungal, Parasitic and Bacterial Infections –
Elevated levels of NO may reduce and impair natural killer (NK)
cell function
• Eating Disorders - Alteration of the NO plays a role in eating
disorders
• Asthma and Allergies – Elevated levels of NO are found in
patients suffering from Asthma and Allergies
• Eczema – NO is an important player in eczema
• Reduced Cerebral Blood Flow – caused by excessive contraction
of brain blood vessels due to astroctytic activation
Natural Killer Cells
Natural killer cells (NK cells) are a part
of the immune system that plays an
important role in eliminating cancer
cells, viruses, bacteria, fungus and
parasites from the body.
Microglial cells control the
communication between neurons
Microglia
Nitric Oxide
Nitric Oxide is a gas naturally found
in the body. NO is an important
mediator and regulator of many
processes in the nervous, immune
and cardiovascular systems.

Synapses Destruction Caused by
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Microglial Activation also occurs in
Alzheimers patients - link to video
Video courtesy of TheHealthScience's Channel
By Dr. Joseph Rogers – Banner Sun Health Research Institute
Video showing how during chronic microglial activation too
many brain connections (synapses) are destroyed leading
to brain underconnectivity and reduced brain function
The immune cells known as microglia, which
were thought to be active in the brain only in
the presence of diseases or infections are
constantly active, they probably play a central
role in one of the most basic functions in the
brain – the creation and destruction of the
synapses.
Compared with normal control brains, the
brains of people with autism showed
evidence of an ongoing inflammatory
process in different regions of the brain
and produced by cells known as microglia
and astroglia, says Dr. Carlos Pardo
Logo courtesy of Johns Hopkins Medicine
Image courtesy of The University of Rochester

Factors that can contribute to
microglial activation in autism
Children with autism suffer from many chronic neurotropic infections
that are associated with microglial activation.
Generally, chronic infections can last several
days, months or a lifetime and at times,
people do not know they are infected
What is a chronic infection?
The role of microglia in the
infections of the central nervous
system
These are agents that prefer to infect the
central nervous system
What are neurotropical infectious
agents?
Examples of neurotropic infections commonly
present in children with autism
For additional information, you may read the
medical article published by the investigators
at the University of Minnesota – School of
Medicine
Viruses
₋ Herpes Family Virues
₋ Coxsackie
₋ Measles
₋ Rubella
₋ Mumps
Bacteria
₋ Lyme Disease
Fungi
Parasites
For additional details, click on
the Minnesota University logo.
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***Anything that can cause an abnormal
immune reaction can activate the microglia

What can be done to regulate
the microglial cells in autism?
Autism should be treated similarly to how the Nobel Prize-winning geneticist
Dr. Mario Capecchi did. By treating the brain’s immune system (microglia).
2010 The Geneticist Winner of the Nobel Prize
Dr. Mario Capecchi,
“What we’re saying is microglia are much more
sophisticated and are actually controlling
behavior, and they have to do it by interacting
the nerve cells in your brain," Capecchi says.
Photo Courtesy of Science News
According to scientists, during chronic microglial activation too many brain connections are destroyed.
If the immune system is treated successfully, the synapses can be completely regenerated.
• Children with autism must be treated with
medications that can block microglial activation.
• Also, they should be treated with medications that
can keep viruses, bacteria, fungus and parasites
under control.
• The Nobel Prize-winning geneticist Dr. Mario Capecchi says
that instead of treating mental illness the traditional way
that doctors do, with drugs to alter brain chemistry, he tried
a new approach, by treating the immune system.
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• We have published and shared a breakthrough medical treatment that targets and
block microglial activation which recent medical research is showing that it is at the
center stage of all the common neurological and medical symptoms in autism.
• We have created a comprehensive medical protocol in English and Spanish that can
be easily followed by doctors.
• There are over 50 medical doctors worldwide treating children with autism using
the medical protocol that Juan Rodriguez discovered.
SCIA Protocol – English Edition SCIA Protocol – Spanish Edition
Our Medical Treatment
Protocol For Autism
Note: The SCIA medical treatment
protocol is intended to be followed
under the medical supervision. Please
read the Terms And Conditions in the
SCIA website carefully before you
proceed to download the SCIA Medical
Treatment Protocol document and start
the protocol.

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• Main part of treatment
1. Prescription strength Ibuprofen to
reduce microglial activation (10
days per month)
2. Specific daily of probiotics helps
modulate the immune response and
keep the stomach lining healthy
• Medications to treat infections
• Viral
• Fungus
• Bacterial
• Parasites
• Medications & supplements to support
immune system function
• Diet
How does the SCIA
protocol works?
Microglial Activation In AutismThe #1 goal of the SCIA protocol is to block

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• Selective serotonin reuptake inhibitors (SSRIs) are believed
to act by inhibiting the reuptake of serotonin after being
released in synapses.
• Anti psychotic (old) Haloperidol, Chlorpromazine,
Thioridazine, and Fluphenazine. They work by controlling
the intensity of the neurotransmitter dopamine in the brain.
• Anti psychotic (new) – Risperdal works in the brain, where it
affects various neurotransmitters, in particular dopamine
and serotonin
• Anticonvulsants work by blocking different
neurotransmitters
• Stimulants – Ritalin significantly increases levels of
dopamine in the brain, thereby stimulating attention and
motivational circuits that enhance one's ability to focus and
complete tasks.
5 Top Mainstream Drugs
For Autism
Image courtesy of Carmen Gottfried and Rudimar Riesgo
"Autism Spectrum Disorders - From Genes to Environment",
These drugs work by altering
the brain chemistry ONLY
addressing the symptoms and
not the root cause!
These drugs attempt to treat the neurological symptoms
by altering the brain chemistry. They don’t target the root
cause which is microglial activation.

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• Hyperbaric Oxygen Therapy (HBOT) works by reducing
nitric oxide levels generated when the microglial cells are
activated. When the nitric oxide levels are reduced the
astrocytes allow the blood vessels in the brain to expand
increasing blood flow and oxygen in the brain. The problem
is that the microglial cells are still activated causing many
children to regress after the HBOT therapy is over.
• Chelation works by reducing the heavy metal toxicity and
oxidative stress. Even after chelation children continue to
suffer from heavy metal accumulation. Microglial cells
generate glutathione (a powerful antioxidant), but when
they become activated the glutathione levels are reduced
not allowing the body to get rid off heavy metals effectively.
Example Of Current Biomedical
Treatments For Autism
Nitric Oxide is a very important
inflammatory mediator. In a low
levels it is very healthy, but in
elevated levels it is very harmful to
the body
Several biomedical treatments show to be beneficial in the
treatment of autism. Many parents report improvements,
but also report regression after a period of time after the
therapies. This is caused because these treatments do not
block microglial activation directly.
Image Courtesy of “N. Allen and B. Barres, 2009”

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Juan Rodriguez have recently published a medical research article that
provides a very accurate and simple medical explanation for autism.
Our Medical Research Provides An
Explanation For The Autism Puzzle

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• World renowned scientists agree with Stop Calling It
Autism! that the root cause of most mental illnesses
including autism is microglial activation
•Dr. Mario Capecchi, Ph.D, Winner Nobel Prize - Medicine
and geneticist at the University of Utah – he published a new study
establishing the cause and effect relationship between the immune
system, specifically microglial cells and psychiatric disorders.
R. Douglas Fields, Ph.D. - Chief of the Nervous System Development and
Plasticity Section, National Institute of Child Health and Development
(NICHD). Recently, he authored the book “The Other Brain”. Dr. Fields
states understanding the glia is the new frontier in brain science.
Carlos Pardo, MD - Associate Professor of Neurology and Pathology at
Johns Hopkins. His research focuses on immunological and molecular
mechanisms of neurological diseases. He also studies the mechanisms
involved in the neuroimmunological diseases linked to autism.
Dr. Mario Capecchi
Photo courtesy of Science News
Dr. Douglas Fields
Photo by Kay
Chernush - courtesy
of NIH
Dr. Carlos Pardo
Photo courtesy of
Science News
Bringing the future of brain
science today

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• Cancer
• In brain cancer microglial cells when activated
are who send the signals for the tumors to
grow.
• Microglial activation leads to brain metastasis
in breast cancer patients
• Alzheimer’s Disease
• Parkinson’s Disease
• Schizophrenia
• Severe Depression
• Down Syndrome
• And more…
Is Microglial Activation
Real?

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• We need to make treatments that block microglial activation
available for individuals with autism that need them.
• We need a pharmaceutical company that can help us bring my
discovery to your local pharmacy
• This breakthrough treatment can be available very soon if the
right people get together
• If this treatment is prescribed to children as soon as they
develop the initial autistic symptoms they could be completely
cured in a very short time
Development of Treatments That
Block Microglial Activation

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• Keep pregnant moms healthy and happy ( diet, exercise & stress free)
• Take probiotics during pregnancy
• Avoid taking any medications during pregnancy (*if possible)
• Avoid C-Sections (*if possible)
• Make sure that moms take probiotics while breastfeeding
• Breastfeed as long as possible
• Supplement infants with probiotics on a daily basis
• Reduce the use of antibiotics in children
• Limit the children’s exposure to anything that is known to activate the
microglia (viruses, bacteria, fungus, parasites, toxins, etc…)
Tips to Prevent Autism
In many children, autism is caused by an abnormal response in their brain’s immune
systems (microglial activation). Children with healthier and better developed immune
systems are less likely to develop autism.
Below is a list of things that are under our control that can greatly reduce the
probability of a child from developing autism.
Probiotics and Toddler Health
The immune system begins to
develop from birth as the gut
microflora becomes populated
with a variety of microorganisms.
Photo courtesy of Nestlé
Visit www.stopcallingitautism.org for more details.
Did you know that breast
milk is rich in probiotics?

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• Modulate the immune response
• Enhance the mucosal gut barrier function
• Prevention and treatment of GI diseases
• Prevention of atopic dermatitis
• Reduced risk of food allergies
Importance of Probiotics
Probiotics are defined by the World Health Organization as live, non-pathogenic
microorganisms that, when administered in adequate amounts, modify the intestinal
microbial population in a way that confers a health benefit to the host. The benefits of
probiotics as a supplement to safely and effectively promote good health are increasingly
well documented.
Benefits of probiotics
Immunity and Probiotics
Detailed report on the effects of the
probiotics in the immune system.
Photo courtesy of Danone
Did you know that a healthy
human being carry 10 times
more good bacteria than
human cells?
• Breast milk
• Women’s vaginas (vaginal delivery is extremely
important for babies)
• Food (i.e.. fermented dairy products)
• Probiotic supplements
Where can probiotics be found?

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• Using the information that I provided today we can
put and end to this devastating epidemic
• Now we know what causes autism
• We can explain how children with autism are
recovering
• We know how we can prevent autism
• The field of glial research is the future of brain
science
• Glial research is growing exponentially
• We have a treatment that blocks microglial activation
available today, we need to partner with a
pharmaceutical company to make it available as a
prepackaged product at our local pharmacies
• Let’s do this for our children and for our society!
Let’s Put An End To The
Autism Epidemic
immune system
cell behind autism.
www.glialtechnologies.com

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Questions?

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