Soft denture liners provide cushioning effects for patients with resorbed ridges and thin mucosa, improving masticatory function. This article describes a new indirect method for applying silicone soft-lined dentures using a photo-activated spacer to control the thickness and location of the soft lining material. The denture base material and soft lining material are simultaneously polymerized. This technique allows for dentures with reliably controlled soft lining material on the intaglio surface and hard-resin marginal base. The method was used successfully in 5 patients who experienced reduced pain and improved mastication.