Joseph El Khoury Webinar July 2014

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Webinar presentation made by Dr. Joseph El Khoury on the 8th of July, 2014 at the live webinar: http://www.alzforum.org/webinars/mutations-impair-trem2-maturation-processing-and-microglial-phagocytosis

(Hickman et al Nature Neuroscience 2013)

TREM2
Mutations
Decreased Aβ
Phagocytosis and
Clearance
Increased Inflammatory
Response
Neurotoxin
Production
(ROS, RNS)
Increased Aβ
Production
Increased Aβ
Accumulation
Microglia
(Hickman & El Khoury Biochemical Pharmacology 2014)

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1. (Hickman et al Nature Neuroscience 2013)

2. TREM2 Mutations Decreased Aβ Phagocytosis and Clearance Increased Inflammatory Response Neurotoxin Production (ROS, RNS) Increased Aβ Production Increased Aβ Accumulation Microglia (Hickman & El Khoury Biochemical Pharmacology 2014)