The distinctive character of modern biology is the study of biology as information. Merging of biology and information sciences is a fundamental drive in biomedicine. Indeed, the post-genomic era is providing a huge of amount of molecular data, pertaining to different levels of evidence, which requires specific expertise in raw data processing, explorative data analysis and systems biology.
Translational genomics relies on our ability to recognize the functional elements of the genome and to disentangle the complexity of their interactions, starting from the sequence and following its implications in transcriptomics, proteomics, metabolomics, epigenomics. The promise of genomic medicine is improved diagnosis and treatment through the application of genomic information and technologies, leading to precision medicine.
This talk will give an overview of computational genomics and its current challenges.
microRNA in Plant Defence and Pathogen Counter-defenceMahtab Rashid
The presentation is about the role of microRNA in plant defence and the pathogen counter-defences which they adopt to escape or evade the plant defence mechanism.
The distinctive character of modern biology is the study of biology as information. Merging of biology and information sciences is a fundamental drive in biomedicine. Indeed, the post-genomic era is providing a huge of amount of molecular data, pertaining to different levels of evidence, which requires specific expertise in raw data processing, explorative data analysis and systems biology.
Translational genomics relies on our ability to recognize the functional elements of the genome and to disentangle the complexity of their interactions, starting from the sequence and following its implications in transcriptomics, proteomics, metabolomics, epigenomics. The promise of genomic medicine is improved diagnosis and treatment through the application of genomic information and technologies, leading to precision medicine.
This talk will give an overview of computational genomics and its current challenges.
microRNA in Plant Defence and Pathogen Counter-defenceMahtab Rashid
The presentation is about the role of microRNA in plant defence and the pathogen counter-defences which they adopt to escape or evade the plant defence mechanism.
Epigenetics and it's relevance in crop improvementShamlyGupta
Epigenetics means ‘above’ or ‘on top of genetics’
A study of the changes in gene expression that are mitotically and/or meiotically heritable and do not involve a change in the DNA sequence
Gene-regulatory information that is not expressed in DNA sequences but transmitted from one generation (of cells or organisms) to the next
Coined by embryologist C. H. Waddington in 1942.
This paper highlights mainly on gene therapy for oral cancer
Oral cancer is one of the deadly disease which need a different vision of treatment because of its pooor prognosis rate.
This paper highlights the basic idea of gene therapy , techniques , steps , its merits & limitations.
microRNAs in Arabidopsis : discovery, functions & involvment in the control o...Frédéric Bouché
Discovered about 20 years ago, microRNA are small non-coding RNA (21-23 nt) involved in the post-transcriptional regulation of gene expression. They are involved in numerous regulatory pathways. However, the analysis of their function and their expression level is a bit tricky, explaining that they were only integrated in the molecular pathways during the last decade.
Here, we present a brief summary of the events that lead to the discovery of microRNAs, as well as the molecular tools used for their analysis and their role in the molecular control of flowering time.
Of course, feel free to leave any constructive comment about those slides !
Epigenetics and it's relevance in crop improvementShamlyGupta
Epigenetics means ‘above’ or ‘on top of genetics’
A study of the changes in gene expression that are mitotically and/or meiotically heritable and do not involve a change in the DNA sequence
Gene-regulatory information that is not expressed in DNA sequences but transmitted from one generation (of cells or organisms) to the next
Coined by embryologist C. H. Waddington in 1942.
This paper highlights mainly on gene therapy for oral cancer
Oral cancer is one of the deadly disease which need a different vision of treatment because of its pooor prognosis rate.
This paper highlights the basic idea of gene therapy , techniques , steps , its merits & limitations.
microRNAs in Arabidopsis : discovery, functions & involvment in the control o...Frédéric Bouché
Discovered about 20 years ago, microRNA are small non-coding RNA (21-23 nt) involved in the post-transcriptional regulation of gene expression. They are involved in numerous regulatory pathways. However, the analysis of their function and their expression level is a bit tricky, explaining that they were only integrated in the molecular pathways during the last decade.
Here, we present a brief summary of the events that lead to the discovery of microRNAs, as well as the molecular tools used for their analysis and their role in the molecular control of flowering time.
Of course, feel free to leave any constructive comment about those slides !
Cisplatin (DDP) is a widely used chemotherapy drug for advanced cervical
cancer (CC), but resistance poses a significant challenge. While miR-4739 has been
implicated in tumor development, its specific role in regulating DDP resistance in CC
remains unclear.
Cisplatin (DDP) is a widely used chemotherapy drug for advanced cervical
cancer (CC), but resistance poses a significant challenge. While miR-4739 has been
implicated in tumor development, its specific role in regulating DDP resistance in CC
remains unclear.
This presentation consists of topics related to oncogene, proto oncogene, Tumor suppresor gene, Ras gene family and structure and functions of tumor suppressor gene.
MAIN MOLECULAR MARKERS OF ORAL SQUAMOUS CELL CARCINOMA / dental implant cour...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
in this research paper ,researchers found a new therapeutic drug that is SULFASALAZINE for the treatment of neuroblastoma that has a action on SEPIATERIN REDUCTASE
1. A STRATEGY TO IDENTIFY THE CIS-ACTING UPSTREAM REGULATORY
ELEMENTS OF A GENE ENCODING AN mRNA BINDING PROTEIN
By
CHRISTOPHER F. JANOWAK
Under the supervision of Dr. Jeffrey Ross
A senior thesis submitted in partial fulfillment of the
requirements for the degree of
Bachelors of Science
Honors in Research
(Genetics)
at the
COLLEGE OF AGRICULTURE AND LIFE SCIENCES
UNIVERSITY OF WISCONSIN-MADISON
2006
2. 1
Abstract
The regulation of gene expression is an important factor in normal cellular
processes. The c-myc coding region instability determinant binding protein (CRD-
BP) is an mRNA-binding protein normally expressed in fetal tissue and silenced in
adult tissues, but is expressed de novo in many types of cancers. Knowing how
CRD-BP is regulated is crucial to understanding its larger biological purpose. The
sequences immediately upstream of the CRD-BP gene show remarkable homology
between human and mouse genomes indicating high evolutionary conservation. We
cloned different sized sequences of DNA upstream of mouse CRD-BP gene into a
modified luciferase mammalian expression vector to systematically analyze the
homologous areas for cis-acting regulatory elements. We will be able to assay for
regulatory element activity in the clones by measuring luciferase activity after
transfection of our clones into mammalian cells.