SlideShare a Scribd company logo
1 of 53
Common Physical Symptoms




    Website: http://ivmsicm.blogspot.com/
                                            1
Common Physical
          Symptoms
          Marc Imhotep Cray, M.D.
           Companion Online Folder:
IVMS-Physical Diagnosis Notes and Reference Resources
Objectives
• Know general guidelines for managing
  nonpain symptoms
• Understand how the principles of intended /
  unintended consequences and double effect
  apply to symptom management
• Know the assessment, management of
  common physical symptoms


                                                3
General management guidelines
             ...
• History, physical examination
• Conceptualize likely causes
• Discuss treatment options, assist with decision
  making



                                               4
Breathlessness (dyspnea) . . .
• May be described as
  – shortness of breath
  – a smothering feeling
  – inability to get enough air
  – suffocation


                                  5
. . . Breathlessness (dyspnea)
• The only reliable measure is patient self-report
• Respiratory rate, pO2, blood gas
  determinations DO NOT correlate with the
  feeling of breathlessness
• Prevalence in the life-threateningly ill: 12 –
  74%

                                                 6
Causes of breathlessness
•   Anxiety              •   Pulmonary embolism
•   Airway obstruction   •   Thick secretions
•   Bronchospasm         •   Anemia
•   Hypoxemia            •   Metabolic
•   Pleural effusion     •   Family / financial / legal
•   Pneumonia                / spiritual / practical
•   Pulmonary edema          issues

                                                          7
Management
           of breathlessness
• Treat the underlying cause
• Symptomatic management
  – oxygen
  – opioids
  – anxiolytics
  – nonpharmacologic interventions




                                     8
Oxygen
•   Pulse oximetry not helpful
•   Potent symbol of medical care
•   Expensive
•   Fan may do just as well




                                    9
Opioids
•   Relief not related to respiratory rate
•   No ethical or professional barriers
•   Small doses
•   Central and peripheral action




                                             10
Anxiolytics
• Safe in combination with opioids
  – lorazepam
     • 0.5-2 mg po q 1 h prn until settled
     • then dose routinely q 4–6 h to keep settled




                                                     11
Nonpharmacologic interventions
            ...
• Reassure, work to manage anxiety
• Behavioral approaches, eg, relaxation,
  distraction, hypnosis
• Limit the number of people in the room
• Open window


                                           12
Nonpharmacologic interventions
            ...
•   Eliminate environmental irritants
•   Keep line of sight clear to outside
•   Reduce the room temperature
•   Avoid chilling the patient



                                          13
. . . Nonpharmacologic
              interventions
• Introduce humidity
• Reposition
  – elevate the head of the bed
  – move patient to one side or other
• Educate, support the family




                                        14
Nausea / vomiting
• Nausea
  – subjective sensation
  – stimulation
     • gastrointestinal lining, CTZ, vestibular apparatus,
       cerebral cortex
• Vomiting
  – neuromuscular reflex



                                                             15
Causes
           of nausea / vomiting
•   Metastases
                            Mechanical
•   Meningeal irritation     obstruction
•   Movement                Motility
•   Mental anxiety          Metabolic
•   Medications             Microbes
•   Mucosal irritation      Myocardial

                                           16
Pathophysiology
        of nausea / vomiting

  Chemoreceptor
Trigger Zone (CTZ)

     Vomiting center

Neurotransmitters
 Serotonin
 Dopamine
 Acetylcholine
 Histamine
                               17
Management
             of nausea / vomiting


•   Dopamine antagonists    •   Prokinetic agents
•   Antihistamines          •   Antacids
•   Anticholinergics        •   Cytoprotective agents
•   Serotonin antagonists   •   Other medications



                                                        18
Dopamine antagonists
•   Haloperidol
•   Prochlorperazine
•   Droperidol
•   Thiethylperazine
•   Promethazine
•   Perphenazine
•   Trimethobenzamide
•   Metoclopramide
                            19
Histamine antagonists
           (antihistamines)
• Diphenhydramine
• Meclizine
• Hydroxyzine




                              20
Acetylcholine antagonists
                (anticholinergics)
• Scopolamine




                                     21
Serotonin antagonists
• Ondansetron
• Granisetron




                             22
Prokinetic agents
• Metoclopramide
• Cisapride




                            23
Antacids

• Antacids
• H2 receptor antagonists
  – cimetidine
  – famotidine
  – ranitidine
• Proton pump inhibitors
  – omeprazole
  – lansoprazole


                            24
Cytoprotective agents
• Misoprostol
• Proton pump inhibitors (omeprazole,
  lansoprazole)




                                        25
Other medications

•   Dexamethasone
•   Tetrahydrocannabinol
•   Lorazepam
•   Octreotide




                           26
Constipation
• Medications           • Metabolic
    – opioids             abnormalities
    – calcium-channel
                        • Spinal cord
      blockers
    – anticholinergic
                          compression
• Decreased motility    • Dehydration
• Ileus                 • Autonomic
                          dysfunction
• Mechanical
  obstruction           • Malignancy


                                          27
Management
            of constipation
• General measures       • Specific measures
   –establish what is       – stimulants
    “normal”                – osmotics
   –regular toileting       – detergents
   –gastrocolic reflex      – lubricants
                            – large volume
                              enemas

                                               28
Stimulant laxatives
•   Prune juice
•   Senna
•   Casanthranol
•   Bisacodyl




                                29
Osmotic laxatives
• Lactulose or sorbitol
• Milk of magnesia (other Mg salts)
• Magnesium citrate




                                      30
Detergent laxatives
           (stool softeners)
• Sodium docusate
• Calcium docusate
• Phosphosoda enema prn




                               31
Prokinetic agents
• Metoclopramide
• Cisapride




                            32
Lubricant stimulants
• Glycerin suppositories
• Oils
  – mineral
  – peanut




                              33
Large-volume enemas
• Warm water
• Soap suds




                           34
Constipation
            from opioids . . .
• Occurs with all opioids
• Pharmacologic tolerance developed slowly, or
  not at all
• Dietary interventions alone usually not
  sufficient
• Avoid bulk-forming agents in debilitated
  patients


                                                 35
. . . Constipation
               from opioids
• Combination stimulant / softeners are useful
  first-line medications
  – casanthranol + docusate sodium
  – senna + docusate sodium
• Prokinetic agents




                                                 36
Causes of diarrhea

•   Infections
•   GI bleeding
•   Malabsorption
•   Medications
•   Obstruction
•   Overflow incontinence
•   Stress

                            37
Management of diarrhea
•   Establish normal bowel pattern
•   Avoid gas-forming foods
•   Increase bulk
•   Transient, mild diarrhea
    – attapulgite
    – bismuth salts



                                     38
Management
          of persistent diarrhea
•   Loperamide
•   Diphenoxylate / atropine
•   Tincture of opium
•   Octreotide




                                   39
Anorexia / cachexia
• Loss of appetite
• Loss of weight




                              40
Management
     of anorexia / cachexia . . .
• Assess, manage comorbid conditions
• Educate, support
• Favorite foods / nutritional supplements




                                             41
. . . Management
         of anorexia / cachexia
•   Alcohol
•   Dexamethasone
•   Megestrol acetate
•   Tetrahydrocannabinol (THC)
•   Androgens




                                  42
Management
        of fatigue / weakness . . .
•   Promote energy conservation
•   Evaluate medications
•   Optimize fluid, electrolyte intake
•   Permission to rest
•   Clarify role of underlying illness
•   Educate, support patient, family
•   Include other disciplines

                                         43
. . . Management
         of fatigue / weakness
• Dexamethasone
  – feeling of well-being, increased energy
  – effect may wane after 4-6 weeks
  – continue until death
• Methylphenidate




                                              44
Fluid balance / edema . . .
• Frequently associated with advanced illness
• Hypoalbuminemia  decreased oncotic
  pressure
• Venous or lymphatic obstruction may
  contribute




                                                45
. . . Fluid balance / edema
•   Limit or avoid IV fluids
•   Urine output will be low
•   Drink some fluids with salt
•   Fragile skin




                                   46
Skin
• Hygiene
• Protection
• Support




                      47
Pressure (decubitus) ulcers
•   Prolonged pressure
•   Inactivity
•   Closely associated with mortality
•   Easier to prevent than treat




                                        48
Odors

• Topical and / or systemic antibiotics
    – metronidazole
    – silver sulfadiazine
•   Kitty litter
•   Activated charcoal
•   Vinegar
•   Burning candles

                                          49
Insomnia
• Assessment of sleep
• Other unrelieved symptoms
• Use family to help assess




                              50
Management
               of insomnia . . .
•   Regular sleep schedule, avoid staying in bed
•   Avoid caffeine, assess alcohol intake
•   Cognitive / physical stimulation
•   Avoid overstimulation
•   Control pain during the night
•   Relaxation, imagery



                                                   51
. . . Management
                  of insomnia
•   Antihistamines
•   Benzodiazepines
•   Neuroleptics
•   Sedating antidepressant (trazodone)
•   Careful titration
•   Attention to adverse effects



                                          52
Reference Resource Folder:
IVMS-Medical Teacher Articles

More Related Content

What's hot

Pharmacology of Anticholinergics - drdhriti
Pharmacology of Anticholinergics  - drdhriti Pharmacology of Anticholinergics  - drdhriti
Pharmacology of Anticholinergics - drdhriti http://neigrihms.gov.in/
 
Introduction to psychopharmacology
Introduction to psychopharmacologyIntroduction to psychopharmacology
Introduction to psychopharmacology1davids1
 
Pharmacology of General anaesthetic drugs.
Pharmacology of General anaesthetic drugs.Pharmacology of General anaesthetic drugs.
Pharmacology of General anaesthetic drugs.Manoj Kumar
 
Anticholinergics drugs-Dr Ramesh Krishnan
Anticholinergics drugs-Dr Ramesh KrishnanAnticholinergics drugs-Dr Ramesh Krishnan
Anticholinergics drugs-Dr Ramesh KrishnanDr Ramesh Krishnan
 
Antirheumatic drugs & anti gout drugs PHARMACOLOGY REVISION NOTES
Antirheumatic drugs & anti gout drugs PHARMACOLOGY REVISION NOTES Antirheumatic drugs & anti gout drugs PHARMACOLOGY REVISION NOTES
Antirheumatic drugs & anti gout drugs PHARMACOLOGY REVISION NOTES TONY SCARIA
 
Management of pain in smallanimals
Management of pain in smallanimalsManagement of pain in smallanimals
Management of pain in smallanimalsSWATHI KRISHNA
 
Drugs used in musculoskeletal disorders i
Drugs used in musculoskeletal disorders iDrugs used in musculoskeletal disorders i
Drugs used in musculoskeletal disorders iPravin Prasad
 
Basics of analgesic drugs
Basics of analgesic drugsBasics of analgesic drugs
Basics of analgesic drugsnon
 
Autacoids ,histamine and antihistaminic
Autacoids ,histamine and antihistaminic Autacoids ,histamine and antihistaminic
Autacoids ,histamine and antihistaminic Ravish Yadav
 
Toxicology for primary care
Toxicology for primary careToxicology for primary care
Toxicology for primary careBooknewt
 
Emetics and anti emetics
Emetics and anti emeticsEmetics and anti emetics
Emetics and anti emeticsCharles Ssekawu
 

What's hot (16)

Pharmacology of Anticholinergics - drdhriti
Pharmacology of Anticholinergics  - drdhriti Pharmacology of Anticholinergics  - drdhriti
Pharmacology of Anticholinergics - drdhriti
 
Introduction to psychopharmacology
Introduction to psychopharmacologyIntroduction to psychopharmacology
Introduction to psychopharmacology
 
Depressants
DepressantsDepressants
Depressants
 
Pharmacology of General anaesthetic drugs.
Pharmacology of General anaesthetic drugs.Pharmacology of General anaesthetic drugs.
Pharmacology of General anaesthetic drugs.
 
Anticholinergics drugs-Dr Ramesh Krishnan
Anticholinergics drugs-Dr Ramesh KrishnanAnticholinergics drugs-Dr Ramesh Krishnan
Anticholinergics drugs-Dr Ramesh Krishnan
 
Antirheumatic drugs & anti gout drugs PHARMACOLOGY REVISION NOTES
Antirheumatic drugs & anti gout drugs PHARMACOLOGY REVISION NOTES Antirheumatic drugs & anti gout drugs PHARMACOLOGY REVISION NOTES
Antirheumatic drugs & anti gout drugs PHARMACOLOGY REVISION NOTES
 
Management of pain in smallanimals
Management of pain in smallanimalsManagement of pain in smallanimals
Management of pain in smallanimals
 
Drugs used in musculoskeletal disorders i
Drugs used in musculoskeletal disorders iDrugs used in musculoskeletal disorders i
Drugs used in musculoskeletal disorders i
 
Psychopharmacology
PsychopharmacologyPsychopharmacology
Psychopharmacology
 
Basics of analgesic drugs
Basics of analgesic drugsBasics of analgesic drugs
Basics of analgesic drugs
 
Autacoids ,histamine and antihistaminic
Autacoids ,histamine and antihistaminic Autacoids ,histamine and antihistaminic
Autacoids ,histamine and antihistaminic
 
Analgesic & antipyretic drugs
Analgesic & antipyretic drugsAnalgesic & antipyretic drugs
Analgesic & antipyretic drugs
 
Toxicology for primary care
Toxicology for primary careToxicology for primary care
Toxicology for primary care
 
Emetics and anti emetics
Emetics and anti emeticsEmetics and anti emetics
Emetics and anti emetics
 
Atropine
AtropineAtropine
Atropine
 
Toxidromes
ToxidromesToxidromes
Toxidromes
 

Similar to IVMS -ICM COMMON SIGNS AND SYMPTOMS

02 Autacoids 11111111 pharmacology 1.pptx
02 Autacoids 11111111 pharmacology 1.pptx02 Autacoids 11111111 pharmacology 1.pptx
02 Autacoids 11111111 pharmacology 1.pptxmickodeguzman2
 
Anticholinergic drugs
Anticholinergic drugsAnticholinergic drugs
Anticholinergic drugsArx Jerin
 
Drugs used in deaaddiction
Drugs used in deaaddictionDrugs used in deaaddiction
Drugs used in deaaddictionsanu108
 
Poisoning in Children Oct 2016.pdfgxtuuzr4
Poisoning in Children Oct 2016.pdfgxtuuzr4Poisoning in Children Oct 2016.pdfgxtuuzr4
Poisoning in Children Oct 2016.pdfgxtuuzr4SimretSolomon5
 
Addiction, Opioids, Cannabis, Cocaine, Alcohol, Stimulants.ppt
Addiction, Opioids, Cannabis, Cocaine, Alcohol, Stimulants.pptAddiction, Opioids, Cannabis, Cocaine, Alcohol, Stimulants.ppt
Addiction, Opioids, Cannabis, Cocaine, Alcohol, Stimulants.pptAziz Mohammad
 
Pharmacology ii chpt 33
Pharmacology ii  chpt 33Pharmacology ii  chpt 33
Pharmacology ii chpt 33shayiamk
 
Addiction –a brain disease
Addiction –a brain diseaseAddiction –a brain disease
Addiction –a brain diseaseTara Rayburn
 
Anticholinergics and drugs acting on autonomic ganglia- drdhriti
Anticholinergics and drugs acting on autonomic ganglia- drdhritiAnticholinergics and drugs acting on autonomic ganglia- drdhriti
Anticholinergics and drugs acting on autonomic ganglia- drdhritihttp://neigrihms.gov.in/
 
Pharmacotherapy of anxiety disorder
Pharmacotherapy of anxiety disorderPharmacotherapy of anxiety disorder
Pharmacotherapy of anxiety disorderPreetKanwal14
 
Week 3 Pharmacokinetics
Week 3 PharmacokineticsWeek 3 Pharmacokinetics
Week 3 PharmacokineticsUbaldo Niña
 
Toxicology djorgenmorris
Toxicology djorgenmorrisToxicology djorgenmorris
Toxicology djorgenmorrisdjorgenmorris
 
Dayton - the Poison Control Center, toxidromes, and "deadly in a dose" pediat...
Dayton - the Poison Control Center, toxidromes, and "deadly in a dose" pediat...Dayton - the Poison Control Center, toxidromes, and "deadly in a dose" pediat...
Dayton - the Poison Control Center, toxidromes, and "deadly in a dose" pediat...John Dayton, MD, FACEP, FAAEM
 
cough and antitussives moa adv uses contra
cough and antitussives moa adv uses contracough and antitussives moa adv uses contra
cough and antitussives moa adv uses contravijiarumugamvsvs
 

Similar to IVMS -ICM COMMON SIGNS AND SYMPTOMS (20)

02 Autacoids 11111111 pharmacology 1.pptx
02 Autacoids 11111111 pharmacology 1.pptx02 Autacoids 11111111 pharmacology 1.pptx
02 Autacoids 11111111 pharmacology 1.pptx
 
Anticholinergic drugs
Anticholinergic drugsAnticholinergic drugs
Anticholinergic drugs
 
Designer drugs
Designer drugsDesigner drugs
Designer drugs
 
Toxicology NC
Toxicology NCToxicology NC
Toxicology NC
 
PHARMA-PSYCHOTHERAPEUTIC AGENTS
PHARMA-PSYCHOTHERAPEUTIC AGENTSPHARMA-PSYCHOTHERAPEUTIC AGENTS
PHARMA-PSYCHOTHERAPEUTIC AGENTS
 
Drugs used in deaaddiction
Drugs used in deaaddictionDrugs used in deaaddiction
Drugs used in deaaddiction
 
Poisoning in Children Oct 2016.pdfgxtuuzr4
Poisoning in Children Oct 2016.pdfgxtuuzr4Poisoning in Children Oct 2016.pdfgxtuuzr4
Poisoning in Children Oct 2016.pdfgxtuuzr4
 
Addiction, Opioids, Cannabis, Cocaine, Alcohol, Stimulants.ppt
Addiction, Opioids, Cannabis, Cocaine, Alcohol, Stimulants.pptAddiction, Opioids, Cannabis, Cocaine, Alcohol, Stimulants.ppt
Addiction, Opioids, Cannabis, Cocaine, Alcohol, Stimulants.ppt
 
Pharmacology ii chpt 33
Pharmacology ii  chpt 33Pharmacology ii  chpt 33
Pharmacology ii chpt 33
 
Anticholinergics
AnticholinergicsAnticholinergics
Anticholinergics
 
Addiction –a brain disease
Addiction –a brain diseaseAddiction –a brain disease
Addiction –a brain disease
 
Anticholinesterase
AnticholinesteraseAnticholinesterase
Anticholinesterase
 
Anticholinergics and drugs acting on autonomic ganglia- drdhriti
Anticholinergics and drugs acting on autonomic ganglia- drdhritiAnticholinergics and drugs acting on autonomic ganglia- drdhriti
Anticholinergics and drugs acting on autonomic ganglia- drdhriti
 
Pharmacotherapy of anxiety disorder
Pharmacotherapy of anxiety disorderPharmacotherapy of anxiety disorder
Pharmacotherapy of anxiety disorder
 
Opioids
OpioidsOpioids
Opioids
 
Week 3 Pharmacokinetics
Week 3 PharmacokineticsWeek 3 Pharmacokinetics
Week 3 Pharmacokinetics
 
Toxicology djorgenmorris
Toxicology djorgenmorrisToxicology djorgenmorris
Toxicology djorgenmorris
 
Dayton - the Poison Control Center, toxidromes, and "deadly in a dose" pediat...
Dayton - the Poison Control Center, toxidromes, and "deadly in a dose" pediat...Dayton - the Poison Control Center, toxidromes, and "deadly in a dose" pediat...
Dayton - the Poison Control Center, toxidromes, and "deadly in a dose" pediat...
 
Pain pharma
Pain pharmaPain pharma
Pain pharma
 
cough and antitussives moa adv uses contra
cough and antitussives moa adv uses contracough and antitussives moa adv uses contra
cough and antitussives moa adv uses contra
 

More from Imhotep Virtual Medical School

Oncologic Pathology_A Case-based Organ Systems Review (USMLE Step 1)
Oncologic Pathology_A Case-based Organ Systems Review (USMLE Step 1)Oncologic Pathology_A Case-based Organ Systems Review (USMLE Step 1)
Oncologic Pathology_A Case-based Organ Systems Review (USMLE Step 1)Imhotep Virtual Medical School
 
Reproductive System Pathology_FM Breast and FM Reproductive Systems
Reproductive System Pathology_FM Breast and FM Reproductive SystemsReproductive System Pathology_FM Breast and FM Reproductive Systems
Reproductive System Pathology_FM Breast and FM Reproductive SystemsImhotep Virtual Medical School
 
Reproductive System Pathology_Male Reproductive Systems
Reproductive System Pathology_Male Reproductive SystemsReproductive System Pathology_Male Reproductive Systems
Reproductive System Pathology_Male Reproductive SystemsImhotep Virtual Medical School
 
Nervous System Pathology_A Case-based Learning Approach
Nervous System Pathology_A Case-based Learning ApproachNervous System Pathology_A Case-based Learning Approach
Nervous System Pathology_A Case-based Learning ApproachImhotep Virtual Medical School
 
CVS Function, Regulation of the Heart and Overview of Therapeutic Goals in CV...
CVS Function, Regulation of the Heart and Overview of Therapeutic Goals in CV...CVS Function, Regulation of the Heart and Overview of Therapeutic Goals in CV...
CVS Function, Regulation of the Heart and Overview of Therapeutic Goals in CV...Imhotep Virtual Medical School
 
Cardiovascular Pathology Case-based_Gross and Microscopic
Cardiovascular Pathology Case-based_Gross and MicroscopicCardiovascular Pathology Case-based_Gross and Microscopic
Cardiovascular Pathology Case-based_Gross and MicroscopicImhotep Virtual Medical School
 
Clinical Pharmacology for Medical Students_USMLE Step 1 & 2 Review
Clinical Pharmacology for Medical Students_USMLE Step 1 & 2 ReviewClinical Pharmacology for Medical Students_USMLE Step 1 & 2 Review
Clinical Pharmacology for Medical Students_USMLE Step 1 & 2 ReviewImhotep Virtual Medical School
 
Make the Dx_ A Case-based Intro to Select Cardiovascular and Respiratory Dise...
Make the Dx_ A Case-based Intro to Select Cardiovascular and Respiratory Dise...Make the Dx_ A Case-based Intro to Select Cardiovascular and Respiratory Dise...
Make the Dx_ A Case-based Intro to Select Cardiovascular and Respiratory Dise...Imhotep Virtual Medical School
 
Myocardial infarction_ Causes, Symptoms, Diagnosis, Treatment, and Pathology
Myocardial infarction_ Causes, Symptoms, Diagnosis, Treatment, and PathologyMyocardial infarction_ Causes, Symptoms, Diagnosis, Treatment, and Pathology
Myocardial infarction_ Causes, Symptoms, Diagnosis, Treatment, and PathologyImhotep Virtual Medical School
 
Autonomic Nervous System Physiology and Pharmacology_Overview| Review of ANS
Autonomic Nervous System Physiology and Pharmacology_Overview| Review of ANSAutonomic Nervous System Physiology and Pharmacology_Overview| Review of ANS
Autonomic Nervous System Physiology and Pharmacology_Overview| Review of ANSImhotep Virtual Medical School
 

More from Imhotep Virtual Medical School (20)

Oncologic Pathology_A Case-based Organ Systems Review (USMLE Step 1)
Oncologic Pathology_A Case-based Organ Systems Review (USMLE Step 1)Oncologic Pathology_A Case-based Organ Systems Review (USMLE Step 1)
Oncologic Pathology_A Case-based Organ Systems Review (USMLE Step 1)
 
Pathology and Pathophysiology of Shock
Pathology and Pathophysiology of ShockPathology and Pathophysiology of Shock
Pathology and Pathophysiology of Shock
 
Drugs Used In Disorders of the Reproductive System
Drugs Used In Disorders of the Reproductive SystemDrugs Used In Disorders of the Reproductive System
Drugs Used In Disorders of the Reproductive System
 
Reproductive System Pathology_FM Breast and FM Reproductive Systems
Reproductive System Pathology_FM Breast and FM Reproductive SystemsReproductive System Pathology_FM Breast and FM Reproductive Systems
Reproductive System Pathology_FM Breast and FM Reproductive Systems
 
Reproductive System Pathology_Male Reproductive Systems
Reproductive System Pathology_Male Reproductive SystemsReproductive System Pathology_Male Reproductive Systems
Reproductive System Pathology_Male Reproductive Systems
 
Nervous System Pathology_A Case-based Learning Approach
Nervous System Pathology_A Case-based Learning ApproachNervous System Pathology_A Case-based Learning Approach
Nervous System Pathology_A Case-based Learning Approach
 
CVS Function, Regulation of the Heart and Overview of Therapeutic Goals in CV...
CVS Function, Regulation of the Heart and Overview of Therapeutic Goals in CV...CVS Function, Regulation of the Heart and Overview of Therapeutic Goals in CV...
CVS Function, Regulation of the Heart and Overview of Therapeutic Goals in CV...
 
Cardiovascular Pathology Case-based_Gross and Microscopic
Cardiovascular Pathology Case-based_Gross and MicroscopicCardiovascular Pathology Case-based_Gross and Microscopic
Cardiovascular Pathology Case-based_Gross and Microscopic
 
HIV / AIDS Pathology
HIV / AIDS PathologyHIV / AIDS Pathology
HIV / AIDS Pathology
 
Sepsis & Septic Shock
Sepsis & Septic ShockSepsis & Septic Shock
Sepsis & Septic Shock
 
Drugs Used in infectious Disease_Antibiotics
Drugs Used in infectious Disease_AntibioticsDrugs Used in infectious Disease_Antibiotics
Drugs Used in infectious Disease_Antibiotics
 
Hematopoietic and Lymphoid Systems Pathology
Hematopoietic and Lymphoid Systems  PathologyHematopoietic and Lymphoid Systems  Pathology
Hematopoietic and Lymphoid Systems Pathology
 
Drugs Used in Neoplastic Disorders
Drugs Used in Neoplastic DisordersDrugs Used in Neoplastic Disorders
Drugs Used in Neoplastic Disorders
 
Neoplasia & Oncologic Pathology
Neoplasia & Oncologic PathologyNeoplasia & Oncologic Pathology
Neoplasia & Oncologic Pathology
 
Clinical Pharmacology for Medical Students_USMLE Step 1 & 2 Review
Clinical Pharmacology for Medical Students_USMLE Step 1 & 2 ReviewClinical Pharmacology for Medical Students_USMLE Step 1 & 2 Review
Clinical Pharmacology for Medical Students_USMLE Step 1 & 2 Review
 
Make the Dx_ A Case-based Intro to Select Cardiovascular and Respiratory Dise...
Make the Dx_ A Case-based Intro to Select Cardiovascular and Respiratory Dise...Make the Dx_ A Case-based Intro to Select Cardiovascular and Respiratory Dise...
Make the Dx_ A Case-based Intro to Select Cardiovascular and Respiratory Dise...
 
Myocardial infarction_ Causes, Symptoms, Diagnosis, Treatment, and Pathology
Myocardial infarction_ Causes, Symptoms, Diagnosis, Treatment, and PathologyMyocardial infarction_ Causes, Symptoms, Diagnosis, Treatment, and Pathology
Myocardial infarction_ Causes, Symptoms, Diagnosis, Treatment, and Pathology
 
Basic CXR Interpretation_Diagnostic Radiographs
Basic CXR Interpretation_Diagnostic RadiographsBasic CXR Interpretation_Diagnostic Radiographs
Basic CXR Interpretation_Diagnostic Radiographs
 
Electrocardiogram (ECG) Interpretation_Module 1 of 2
Electrocardiogram (ECG) Interpretation_Module 1 of 2Electrocardiogram (ECG) Interpretation_Module 1 of 2
Electrocardiogram (ECG) Interpretation_Module 1 of 2
 
Autonomic Nervous System Physiology and Pharmacology_Overview| Review of ANS
Autonomic Nervous System Physiology and Pharmacology_Overview| Review of ANSAutonomic Nervous System Physiology and Pharmacology_Overview| Review of ANS
Autonomic Nervous System Physiology and Pharmacology_Overview| Review of ANS
 

Recently uploaded

SOCIAL AND HISTORICAL CONTEXT - LFTVD.pptx
SOCIAL AND HISTORICAL CONTEXT - LFTVD.pptxSOCIAL AND HISTORICAL CONTEXT - LFTVD.pptx
SOCIAL AND HISTORICAL CONTEXT - LFTVD.pptxiammrhaywood
 
Measures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and ModeMeasures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and ModeThiyagu K
 
mini mental status format.docx
mini    mental       status     format.docxmini    mental       status     format.docx
mini mental status format.docxPoojaSen20
 
Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3JemimahLaneBuaron
 
Hybridoma Technology ( Production , Purification , and Application )
Hybridoma Technology  ( Production , Purification , and Application  ) Hybridoma Technology  ( Production , Purification , and Application  )
Hybridoma Technology ( Production , Purification , and Application ) Sakshi Ghasle
 
Arihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdfArihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdfchloefrazer622
 
Introduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher EducationIntroduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher Educationpboyjonauth
 
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Sapana Sha
 
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...EduSkills OECD
 
Kisan Call Centre - To harness potential of ICT in Agriculture by answer farm...
Kisan Call Centre - To harness potential of ICT in Agriculture by answer farm...Kisan Call Centre - To harness potential of ICT in Agriculture by answer farm...
Kisan Call Centre - To harness potential of ICT in Agriculture by answer farm...Krashi Coaching
 
Incoming and Outgoing Shipments in 1 STEP Using Odoo 17
Incoming and Outgoing Shipments in 1 STEP Using Odoo 17Incoming and Outgoing Shipments in 1 STEP Using Odoo 17
Incoming and Outgoing Shipments in 1 STEP Using Odoo 17Celine George
 
Presiding Officer Training module 2024 lok sabha elections
Presiding Officer Training module 2024 lok sabha electionsPresiding Officer Training module 2024 lok sabha elections
Presiding Officer Training module 2024 lok sabha electionsanshu789521
 
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptxContemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptxRoyAbrique
 
Science 7 - LAND and SEA BREEZE and its Characteristics
Science 7 - LAND and SEA BREEZE and its CharacteristicsScience 7 - LAND and SEA BREEZE and its Characteristics
Science 7 - LAND and SEA BREEZE and its CharacteristicsKarinaGenton
 
Grant Readiness 101 TechSoup and Remy Consulting
Grant Readiness 101 TechSoup and Remy ConsultingGrant Readiness 101 TechSoup and Remy Consulting
Grant Readiness 101 TechSoup and Remy ConsultingTechSoup
 
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...Marc Dusseiller Dusjagr
 
Industrial Policy - 1948, 1956, 1973, 1977, 1980, 1991
Industrial Policy - 1948, 1956, 1973, 1977, 1980, 1991Industrial Policy - 1948, 1956, 1973, 1977, 1980, 1991
Industrial Policy - 1948, 1956, 1973, 1977, 1980, 1991RKavithamani
 
Mastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory InspectionMastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory InspectionSafetyChain Software
 

Recently uploaded (20)

SOCIAL AND HISTORICAL CONTEXT - LFTVD.pptx
SOCIAL AND HISTORICAL CONTEXT - LFTVD.pptxSOCIAL AND HISTORICAL CONTEXT - LFTVD.pptx
SOCIAL AND HISTORICAL CONTEXT - LFTVD.pptx
 
Measures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and ModeMeasures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and Mode
 
mini mental status format.docx
mini    mental       status     format.docxmini    mental       status     format.docx
mini mental status format.docx
 
Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3Q4-W6-Restating Informational Text Grade 3
Q4-W6-Restating Informational Text Grade 3
 
Hybridoma Technology ( Production , Purification , and Application )
Hybridoma Technology  ( Production , Purification , and Application  ) Hybridoma Technology  ( Production , Purification , and Application  )
Hybridoma Technology ( Production , Purification , and Application )
 
Arihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdfArihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdf
 
Código Creativo y Arte de Software | Unidad 1
Código Creativo y Arte de Software | Unidad 1Código Creativo y Arte de Software | Unidad 1
Código Creativo y Arte de Software | Unidad 1
 
Introduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher EducationIntroduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher Education
 
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111Call Girls in Dwarka Mor Delhi Contact Us 9654467111
Call Girls in Dwarka Mor Delhi Contact Us 9654467111
 
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
 
Kisan Call Centre - To harness potential of ICT in Agriculture by answer farm...
Kisan Call Centre - To harness potential of ICT in Agriculture by answer farm...Kisan Call Centre - To harness potential of ICT in Agriculture by answer farm...
Kisan Call Centre - To harness potential of ICT in Agriculture by answer farm...
 
TataKelola dan KamSiber Kecerdasan Buatan v022.pdf
TataKelola dan KamSiber Kecerdasan Buatan v022.pdfTataKelola dan KamSiber Kecerdasan Buatan v022.pdf
TataKelola dan KamSiber Kecerdasan Buatan v022.pdf
 
Incoming and Outgoing Shipments in 1 STEP Using Odoo 17
Incoming and Outgoing Shipments in 1 STEP Using Odoo 17Incoming and Outgoing Shipments in 1 STEP Using Odoo 17
Incoming and Outgoing Shipments in 1 STEP Using Odoo 17
 
Presiding Officer Training module 2024 lok sabha elections
Presiding Officer Training module 2024 lok sabha electionsPresiding Officer Training module 2024 lok sabha elections
Presiding Officer Training module 2024 lok sabha elections
 
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptxContemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
 
Science 7 - LAND and SEA BREEZE and its Characteristics
Science 7 - LAND and SEA BREEZE and its CharacteristicsScience 7 - LAND and SEA BREEZE and its Characteristics
Science 7 - LAND and SEA BREEZE and its Characteristics
 
Grant Readiness 101 TechSoup and Remy Consulting
Grant Readiness 101 TechSoup and Remy ConsultingGrant Readiness 101 TechSoup and Remy Consulting
Grant Readiness 101 TechSoup and Remy Consulting
 
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
 
Industrial Policy - 1948, 1956, 1973, 1977, 1980, 1991
Industrial Policy - 1948, 1956, 1973, 1977, 1980, 1991Industrial Policy - 1948, 1956, 1973, 1977, 1980, 1991
Industrial Policy - 1948, 1956, 1973, 1977, 1980, 1991
 
Mastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory InspectionMastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory Inspection
 

IVMS -ICM COMMON SIGNS AND SYMPTOMS

  • 1. Common Physical Symptoms Website: http://ivmsicm.blogspot.com/ 1
  • 2. Common Physical Symptoms Marc Imhotep Cray, M.D. Companion Online Folder: IVMS-Physical Diagnosis Notes and Reference Resources
  • 3. Objectives • Know general guidelines for managing nonpain symptoms • Understand how the principles of intended / unintended consequences and double effect apply to symptom management • Know the assessment, management of common physical symptoms 3
  • 4. General management guidelines ... • History, physical examination • Conceptualize likely causes • Discuss treatment options, assist with decision making 4
  • 5. Breathlessness (dyspnea) . . . • May be described as – shortness of breath – a smothering feeling – inability to get enough air – suffocation 5
  • 6. . . . Breathlessness (dyspnea) • The only reliable measure is patient self-report • Respiratory rate, pO2, blood gas determinations DO NOT correlate with the feeling of breathlessness • Prevalence in the life-threateningly ill: 12 – 74% 6
  • 7. Causes of breathlessness • Anxiety • Pulmonary embolism • Airway obstruction • Thick secretions • Bronchospasm • Anemia • Hypoxemia • Metabolic • Pleural effusion • Family / financial / legal • Pneumonia / spiritual / practical • Pulmonary edema issues 7
  • 8. Management of breathlessness • Treat the underlying cause • Symptomatic management – oxygen – opioids – anxiolytics – nonpharmacologic interventions 8
  • 9. Oxygen • Pulse oximetry not helpful • Potent symbol of medical care • Expensive • Fan may do just as well 9
  • 10. Opioids • Relief not related to respiratory rate • No ethical or professional barriers • Small doses • Central and peripheral action 10
  • 11. Anxiolytics • Safe in combination with opioids – lorazepam • 0.5-2 mg po q 1 h prn until settled • then dose routinely q 4–6 h to keep settled 11
  • 12. Nonpharmacologic interventions ... • Reassure, work to manage anxiety • Behavioral approaches, eg, relaxation, distraction, hypnosis • Limit the number of people in the room • Open window 12
  • 13. Nonpharmacologic interventions ... • Eliminate environmental irritants • Keep line of sight clear to outside • Reduce the room temperature • Avoid chilling the patient 13
  • 14. . . . Nonpharmacologic interventions • Introduce humidity • Reposition – elevate the head of the bed – move patient to one side or other • Educate, support the family 14
  • 15. Nausea / vomiting • Nausea – subjective sensation – stimulation • gastrointestinal lining, CTZ, vestibular apparatus, cerebral cortex • Vomiting – neuromuscular reflex 15
  • 16. Causes of nausea / vomiting • Metastases  Mechanical • Meningeal irritation obstruction • Movement  Motility • Mental anxiety  Metabolic • Medications  Microbes • Mucosal irritation  Myocardial 16
  • 17. Pathophysiology of nausea / vomiting Chemoreceptor Trigger Zone (CTZ) Vomiting center Neurotransmitters  Serotonin  Dopamine  Acetylcholine  Histamine 17
  • 18. Management of nausea / vomiting • Dopamine antagonists • Prokinetic agents • Antihistamines • Antacids • Anticholinergics • Cytoprotective agents • Serotonin antagonists • Other medications 18
  • 19. Dopamine antagonists • Haloperidol • Prochlorperazine • Droperidol • Thiethylperazine • Promethazine • Perphenazine • Trimethobenzamide • Metoclopramide 19
  • 20. Histamine antagonists (antihistamines) • Diphenhydramine • Meclizine • Hydroxyzine 20
  • 21. Acetylcholine antagonists (anticholinergics) • Scopolamine 21
  • 24. Antacids • Antacids • H2 receptor antagonists – cimetidine – famotidine – ranitidine • Proton pump inhibitors – omeprazole – lansoprazole 24
  • 25. Cytoprotective agents • Misoprostol • Proton pump inhibitors (omeprazole, lansoprazole) 25
  • 26. Other medications • Dexamethasone • Tetrahydrocannabinol • Lorazepam • Octreotide 26
  • 27. Constipation • Medications • Metabolic – opioids abnormalities – calcium-channel • Spinal cord blockers – anticholinergic compression • Decreased motility • Dehydration • Ileus • Autonomic dysfunction • Mechanical obstruction • Malignancy 27
  • 28. Management of constipation • General measures • Specific measures –establish what is – stimulants “normal” – osmotics –regular toileting – detergents –gastrocolic reflex – lubricants – large volume enemas 28
  • 29. Stimulant laxatives • Prune juice • Senna • Casanthranol • Bisacodyl 29
  • 30. Osmotic laxatives • Lactulose or sorbitol • Milk of magnesia (other Mg salts) • Magnesium citrate 30
  • 31. Detergent laxatives (stool softeners) • Sodium docusate • Calcium docusate • Phosphosoda enema prn 31
  • 33. Lubricant stimulants • Glycerin suppositories • Oils – mineral – peanut 33
  • 34. Large-volume enemas • Warm water • Soap suds 34
  • 35. Constipation from opioids . . . • Occurs with all opioids • Pharmacologic tolerance developed slowly, or not at all • Dietary interventions alone usually not sufficient • Avoid bulk-forming agents in debilitated patients 35
  • 36. . . . Constipation from opioids • Combination stimulant / softeners are useful first-line medications – casanthranol + docusate sodium – senna + docusate sodium • Prokinetic agents 36
  • 37. Causes of diarrhea • Infections • GI bleeding • Malabsorption • Medications • Obstruction • Overflow incontinence • Stress 37
  • 38. Management of diarrhea • Establish normal bowel pattern • Avoid gas-forming foods • Increase bulk • Transient, mild diarrhea – attapulgite – bismuth salts 38
  • 39. Management of persistent diarrhea • Loperamide • Diphenoxylate / atropine • Tincture of opium • Octreotide 39
  • 40. Anorexia / cachexia • Loss of appetite • Loss of weight 40
  • 41. Management of anorexia / cachexia . . . • Assess, manage comorbid conditions • Educate, support • Favorite foods / nutritional supplements 41
  • 42. . . . Management of anorexia / cachexia • Alcohol • Dexamethasone • Megestrol acetate • Tetrahydrocannabinol (THC) • Androgens 42
  • 43. Management of fatigue / weakness . . . • Promote energy conservation • Evaluate medications • Optimize fluid, electrolyte intake • Permission to rest • Clarify role of underlying illness • Educate, support patient, family • Include other disciplines 43
  • 44. . . . Management of fatigue / weakness • Dexamethasone – feeling of well-being, increased energy – effect may wane after 4-6 weeks – continue until death • Methylphenidate 44
  • 45. Fluid balance / edema . . . • Frequently associated with advanced illness • Hypoalbuminemia  decreased oncotic pressure • Venous or lymphatic obstruction may contribute 45
  • 46. . . . Fluid balance / edema • Limit or avoid IV fluids • Urine output will be low • Drink some fluids with salt • Fragile skin 46
  • 48. Pressure (decubitus) ulcers • Prolonged pressure • Inactivity • Closely associated with mortality • Easier to prevent than treat 48
  • 49. Odors • Topical and / or systemic antibiotics – metronidazole – silver sulfadiazine • Kitty litter • Activated charcoal • Vinegar • Burning candles 49
  • 50. Insomnia • Assessment of sleep • Other unrelieved symptoms • Use family to help assess 50
  • 51. Management of insomnia . . . • Regular sleep schedule, avoid staying in bed • Avoid caffeine, assess alcohol intake • Cognitive / physical stimulation • Avoid overstimulation • Control pain during the night • Relaxation, imagery 51
  • 52. . . . Management of insomnia • Antihistamines • Benzodiazepines • Neuroleptics • Sedating antidepressant (trazodone) • Careful titration • Attention to adverse effects 52