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Toxicology
chapter 27
By: a former student (and Diane)
Introduction
• Rarely will you not encounter a drug addict
or abuser in a 12 hr shift.
• Licit- legal
• Illicit- illegal
• Alcohol- most common abuse
Routes of Exposure
• Ingestion
• Inhalation
• Injection
• Absorption
Ingestion
• Damage may be immediate or take place
over several hours
• Acid or alkali- immediate
• Household medications and cleaning supplies
are most common
Inhalation
• Present in surrounding area
• Accidental or intentional
• Scene safety
Injection
• Stings, bites, intravenous
• Neurotoxic, localized, or systemic reactions
• Physical findings will give you the most clues
Absorption
• Pesticides and organophosphates
Toxidromes (Toxic Syndrome)
It’s too damn hard to memorize all the
harmful substances, so let’s just put
them into some categories:
Narcotic
Sympathomimetic
Sedative-hypnotic
Cholinergic
Anticholinergic
Narcotics (opiates or opioids)
morphine, codeine, heroin, methadone, opium,
hyrdromorphone, fentanyl, oxycodone
hypoventilation, respiratory arrest, miosis,
bradycardia, hypotension, drowsiness, stupor,
coma
Sympathomimetics (uppers?)
• Pseudoephedrine, phenylephrine,
phenylpropanolamine, amphetamines,
methamphetamine, cocaine, nasal
decongestants, synthetic cathinones (bath
salts)
• Hypertension, diaphoresis, tachycardia,
tachypnea, dilated pupils (mydriasis),
agitation, seizures, hyperthermia, paranoia
Sedative-hypnotic (downers?)
• Phenobarbital, secobarbital, diazepam,
thiopental, midazolam, lorazepam, propofol,
ethanol, flunitrazepam, zolpidem tartrate
• Hypoventilation, respiratory arrest,
drowsiness, disinhibition, ataxia, slurred
speech, mental confusion, respiratory
depression, progressive CNS depression
Cholinergic
• Organophosphates, acephate, diazinon,
malathion, parathion, sarin, tabun, V agent
• Diarrhea, urination, miosis, muscle
weakness, bradycardia/bronchospasm,
emesis, lacrimation, seizures, salivation,
seating, respiratory depression, coma,
tachycardia
Anticholinergic
• Atropine, scopolamine, antihistamines,
chlorpheniramine, tricyclic antidepressants,
antipsychotic, jimson weed
History taking…
• What?
• When?
• How much?
• Nothing else?
• Vomit?
• Why?
Emergency Care
• Scene safety
• Airway
• Breathing
• Circulation
• Oxygen
• IV
• Antidote if possible
• Prepare to manage shock, seizure, coma, and
dysrhythmias.
• Transport in left lateral position.
Alcohol intoxication and
withdrawal
• Most widely abused drug
• Death can occur with BAC of 0.40% (400
mg/dL)
Withdrawal seizures
• Usually occur 12 to 48 hours after stopping
Delirium tremens
• Serious and lethal
• Usually start 48 to 72 hours after last drink
• Mortality reported as high as 15%
Stimulants
• Cocaine
• Amphetamine, methamphetamine, and
amphetamin-like drugs
• BATH SALTS!!!!!!
Cocaine
• Naturally occurring alkaloid that is
extracted from the erythroxylon coca plant
• Processed into cocaine hydrochloride
Pathophysiology
• Local anesthetic and a CNS stimulant
• Release of NE, dopamine, and seratonin
• Water-soluble hydrochloride salt
• Look for widened QRS or prolonged QT
interval
• Crack cocaine- mix with baking soda and
water and enjoy
Treatment
• Valium or lorazepam for seizures
• Nitroglycerin for chest pain
• Chemical restraints may be needed
• No Beta Blockers
Amphetamines
• MDA and MDMA (Molly)
• Amphetamines are structurally similar to
the derivatives of phenylethylamine and
include methamphetamine (crank or ice)
• Most nasal decongestants and diet pills are
members of this family
methamphetamine
• Low cost and long acting stimulant that is
extremely addictive
• Meth labs
• Prehospital care is supportive care
BATH SALTS
• Synthetic cathinones
• Similar to MDMA
• Sudafed
• Snort, smoke, or ingest drug
• Side effects are eating people and similar to
methamphetamines
Excited Delerium
• Haldol and Benadryl !
• Ketamine
• 2 mg/kg IV
• 4 mg/kg IM
• Cool them down
• Treat seizures
• Possible rhabdomyolysis
Marijuana
and other cannabis stuff
delta 9-tetrahydrocannibinol
(THC)
• Binds to cannabinoid receptors in brain
• tachycardia, coordination problems,
increased appetite, dry mouth, memory loss,
drowsiness
• Euphoria can last 4 to 6 hours.
Spice
• Synthetic cannabinoid
• Can be more dangerous
• Psychosis, hallucinogens, tachycardia, renal
conditions, seizures
Cannabidiol
• One of the main active ingredients
• antiseizure, neuroprotective, analgesia, and
antitumor
• Does not have euphoric, intoxicating effects
of THC.
Hallucinogens
Substance that causes some
distortion of sense perception
LSD
• Primarily affects the senses then physiologic
functions
• The effects are mostly sympathomimetic
• Seratonin receptor agonist
Phencyclidine
• PCP
• Can cause some of the most violent and
difficult behavior you will encounter
Ketamine
• Dissociative anesthetic
• Works on NMDA receptors like PCP
Psilocybin Mushrooms
Sedative Hypnotics
Sedatives and hypnotics
• Used to reduce anxiety and to calm cray
cray patients
Barbiturates
• Long acting, intermediate acting, short
acting, and ultra short acting
Barbituates
• Airway, fluids, dopamine ?, bicarb to alkalize
the urine:
• 1 to 2 mEq/kg in 1 L of D5
Benzodiazepines
• Sedative properties
• Stimulate the gamma-aminobutyric acid
pathways
• Sedates, reduce anxiety, and relaxation of
striated muscle
Narcotics, Opiates, and Opioids
Narcotics
• Drug that produces sleep or altered mental
status
• Derived from opium
• Some not derived from opium
Cardiac medications
• Class 1
• Class 2
• Class 3
• Class 4
• Class 5
Cardiac medications
• Class 1
• Class 2- consider glucagon
• Class 3
• Class 4- give calcium or glucagon
• Class 5
• Check BgL
• Call Poison Control early; Charcoal?
Cardiac Glycosides
Organophosphates
• Major component in many insecticides
• Inhibits acetylcholinesterase
• Suicide attempts account for a considerable
share of organophosphates poisonings
•
DUMBELS
• Diarrhea
• Urination
• Miosis
• Bradycardia, bronchospasm,
• bronchorrhea
• Emesis
• Lacrimation
• Seizures, saliva, sweating
TREATMENT
• Airway, suction as needed
• O2
• IV
• Atropine 1 mg every 3 to 5 minutes until
atropinization occurs
• Pralidoxime (2-PAM) up to 3 autoinjections
(600 mg each)
Nerve Agent Poisoning
• Chlorine gas
• When hypochlorite mixes with a strong acid
• Syrian Nerve Gas Attack
Carbon Monoxide Poisoning
• Causes more poisoning deaths than any
other toxic substance
• High affinity for hemoglobin
• Colorless, odorless, tasteless
CO + Hemoglobin =
Carboxyhemoglobin (COHb)
COHb Half-life
• Room air – 4 hours
• 100% O2 – 1.5 hours
• Hyperbaric O2 – 15 to 20 minutes
• Consider cyanide poisoning also !
Chlorine
• Swimming pools and water treatment
plants
• Nebulize albuterol for wheezing
• Nebulize sodium bicarb for relief (per med
control)
Cyanide
• Used in industry for electroplanting, ore
extraction and fumigation of buildings
• bitter almond scent
• Cyanide binds with cytochrome oxidase
• Suffocates at the cellular level
Cyanide Poisoning Treatment
Nitrite Overdose
Caustics
• Strong acids pH < 2.0
• Coagulation necrosis
• Strong bases pH > 12.0
• Liquifaction necrosis
Drugs Abused for Sexual
Gratification
• MDMA, Dextromorphan
• Phosphodiesterase type 5 (PDE5) Inhibitors
• sildenafil - Viagra
• tadalafil - Cialis
• vardenafil – Levitra
Date Rape Drugs
• GHB Gamma-hydroxbuyrate
• Rohypnol (Flunitrazepam)
Poisonous Alcohols
• Methyl Alcohol
• methanol
• wood alcohol
• Give bicarb?
• Ethylene Glycol
• Antifreeze
• Lethal dose of 2 mL/kg
• Give 10 mL (1 g) of calcium gluconate
Hydrocarbons
• “cheap buzz”
• Treatment is supportive
Hydrogen Sulfide (treatment)
• Amyl nitrite
• Sodium nitrite
Psychiatric medications
Tricyclic antidepressants
• TCA’s
• Require close attention to regiment
• Small therapeutic window
• Consider sodium bicarb
Monoamine oxidase inhibitors
• MAOIs
• Treat atypical depression
• Increase norepinephrine and serotonin
• Need to avoid food with Tyramine
Selective Serotonin reuptake
inhibitors
• SSRIs
• Larger therapeutic window
• Increases safety margin
SSRIs
• Prozac
• Paxil
• Zoloft
• Seratonin syndrome- give cyproheptadine
Lithium
• Cornerstone treatment for bi polar disorder
• bipolar gif
NSAIDS
• Bleeding
• Asceptic meningitis
• stiff neck
• headache
• fever
Salicylates
• ASA and Pept-Bismol
• Toxicity at 300 mg/kg
• Give bicarb
Acetaminophen
• 150 mg/kg is toxic
• Give acetylcysteine – Acetadote, Mucomyst
Lead Poisoning
• 90% stored in bone
• Accumulates
• Causes cerebral edema
Iron
60 mg/kg severe toxicity
Metabolic acidosis
Charcoal does not work
60 mg/kg is toxic
Poisonous Plants
Dieffenbachia
Caladium
Lantana
Foxglove
Castor Beans
Amanita
Food Poisoning
• Salmonella
• Listeria
• Toxoplasma
• Clostridium botulinum

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