This document summarizes anticholinergic drugs. It discusses that they block the effects of acetylcholine on cholinergic receptors, with atropine being the prototype drug. The document classifies anticholinergic drugs into natural alkaloids like atropine and hyoscine, semisynthetic derivatives, and synthetic derivatives. It then describes the mechanism of action, effects, pharmacokinetics, adverse effects, belladonna poisoning, and uses of these anticholinergic drugs like atropine.
2. INTRODUCTION :
• Agents which block the effects of Ach on cholinergic
receptors.
• Commonly antimuscarinic drugs are considered as
anticholinergic drugs.
• [PARASYMPATHOLYTIC DRUGS]
• Atropine is the prototype drug.
4. ATROPINE
• It is a natural alkaloid Obtained from atropine
belladonna.
• They are muscarinic antagonist.
5. MECHANISM OF ACTION :
• Bind to muscarinic receptors & block the effects of acetylcholine at
the receptors.
• Competitive antagonist.
• Antagonism reversible by increasing the concentration of agonist.
• Acetylcholine & scopolamine are non- selective antagonist & block
all the sub types (M1 to M5)