International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
A slide show of the paper- Tribology of artificial joints, T D Stewart BSc PhD Lecturer in Medical Engineering, Institute of Medical and Biological Engineering, The University of Leeds, Leeds, UK, Journal- ORTHOPAEDICS AND TRAUMA 24:6
articular cartilage present in joint surface of articulating bone .role of articular cartilage in load bearing is important its damage cause arthritis so should know about its biomechanics
A slide show of the paper- Tribology of artificial joints, T D Stewart BSc PhD Lecturer in Medical Engineering, Institute of Medical and Biological Engineering, The University of Leeds, Leeds, UK, Journal- ORTHOPAEDICS AND TRAUMA 24:6
articular cartilage present in joint surface of articulating bone .role of articular cartilage in load bearing is important its damage cause arthritis so should know about its biomechanics
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is a team of researchers not publication services or private publications running the journals for monetary benefits, we are association of scientists and academia who focus only on supporting authors who want to publish their work. The articles published in our journal can be accessed online, all the articles will be archived for real time access.
Our journal system primarily aims to bring out the research talent and the works done by sciaentists, academia, engineers, practitioners, scholars, post graduate students of engineering and science. This journal aims to cover the scientific research in a broader sense and not publishing a niche area of research facilitating researchers from various verticals to publish their papers. It is also aimed to provide a platform for the researchers to publish in a shorter of time, enabling them to continue further All articles published are freely available to scientific researchers in the Government agencies,educators and the general public. We are taking serious efforts to promote our journal across the globe in various ways, we are sure that our journal will act as a scientific platform for all researchers to publish their works online.
Maxillofacial Surgery
Dental Students Fifth Year First semester
Lecture Name TMJ anatomy examination 2
Lecture 9
Al Azhar University Gaza Palestine
Dr. Lama El Banna
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
International Journal of Engineering Research and Applications (IJERA) is a team of researchers not publication services or private publications running the journals for monetary benefits, we are association of scientists and academia who focus only on supporting authors who want to publish their work. The articles published in our journal can be accessed online, all the articles will be archived for real time access.
Our journal system primarily aims to bring out the research talent and the works done by sciaentists, academia, engineers, practitioners, scholars, post graduate students of engineering and science. This journal aims to cover the scientific research in a broader sense and not publishing a niche area of research facilitating researchers from various verticals to publish their papers. It is also aimed to provide a platform for the researchers to publish in a shorter of time, enabling them to continue further All articles published are freely available to scientific researchers in the Government agencies,educators and the general public. We are taking serious efforts to promote our journal across the globe in various ways, we are sure that our journal will act as a scientific platform for all researchers to publish their works online.
Maxillofacial Surgery
Dental Students Fifth Year First semester
Lecture Name TMJ anatomy examination 2
Lecture 9
Al Azhar University Gaza Palestine
Dr. Lama El Banna
Lipid Translocation (flip-flop) as One of the Least Understood Dynamical Proc...asclepiuspdfs
The lipids molecules translocation in phospholipid membrane is named the (flip-flop) event. For this purpose, the translocation
may take place in vivo with the surface of articular cartilage. Flip-flops are one of the least understood dynamical processes
in vivo in cartilage membranes. In this work, we explain the molecular mechanism lipid translocation (flip-flop) in vivo
during the drying process cartilage surface. Wettability of cartilage surface versus drying time was determined. Our findings
strongly support the idea that the process of translocation lipid (flip-flop) transformed the hydrophilic surface in hydrophobic
in dry-air conditions for healthy and osteoarthritic cartilage. Such material can be classified as “smart material” and this fact
is poorly known in the literature.
Micro and nanoengineering approaches to developing gradient biomaterials sui...Dr. Sitansu Sekhar Nanda
Interface tissue found between soft and hard tissue regions such as cartilage-bone, tendon-bone, ligament-bone and other tissues. (e.g. dentin-enamel). Conventional Biomaterials are monophasic or composite materials are inefficient facilitating tissue formation. So, gradient materials are required for interface tissue engineering.
This report focuses on study of behavior of a human knee cartilage on application of point load. A cartilage is a tissue which covers the long bones at the knee joint.it is known as articular cartilage in the medical world. It prevents osteoarthritis and other knee related injuries. The main challenge of this project was to define material properties of bone and cartilage in ANSYS workbench. Initially the physical structure and function of knee bone and cartilage is defined and all the material properties are defined in workbench and in the subsequent section a thorough explicit analysis is done on ANSYS workbench and force vs displacement, internal energy-time graphs are plotted. Next, a structural and 2D analysis done in ANSYS –APDL. Next an explicit analysis done in LS-Dyna and plots for displacement-force and Internal energy-time are determined.
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Role of water in Biomaterials· The primary role water plays in bMalikPinckney86
Role of water in Biomaterials
· The primary role water plays in biomaterials is as a solvent system.
· Water is the “universal ether” as it has been termed (Baier and Meyer, 1996), dissolving inorganic salts and large organic macromolecules such as proteins or carbohydrates (solutes) with nearly equal efficiency (Pain, 1982).
· Water is an active participant in biology, which simply could not and would not work the way it does without the special mediating properties of water.
· Moreover, it is widely believed that water is the first molecule to contact biomaterials in any clinical application (Andrade et al., 1981; Baier, 1978).
· This is because water is the majority molecule in any biological mixture, constituting 70 wt % or more of most living organisms, and because water is such a small and agile molecule, only about 0.25 nm in the longest dimension.
· Consequently, behavior of water near surfaces and the role of water in biology are very important subjects in biomaterials science.
· Self-association confers unique properties on water, many of which are still active areas of scientific investigation even after more than 200 years of chemical and physical research applied to water (Franks, 1972).
WATER SOLVENT PROPERTIES
A
C
B
D
FIG. Atomic structure of water illustrating (A) tetrahedral bonding arrangement wherein hydrogen atoms (H, light-colored spheres) are Lewis acid centers and the two lone-pair electrons on oxygen (O, dark-colored spheres) are Lewis base centers that permit water to hydrogen bond with four nearest-neighbor water molecules; (B) electron density map superimposed on an atomic-radius sphere model of water providing a more authentic representation of molecular water; (C) approximate molecular dimensions; and (D) five water molecules participating in a portion of a hydrogen-bond network.
· Hydrogen bonds in water are relatively weak 3–5 kcal/mole associations with little covalent character (Iassacs et al., 1999; Marshall, 1999).
· Hydrogen bonds are quite transient in nature, persisting only for a few tens of picoseconds (Berendsen, 1967; Luzar and Chandler, 1996).
· Modern molecular simulations suggest, however, that more than 75% of liquid-water molecules are interconnected in a three-dimensional (3D) network of three or four nearest neighbors at any particular instant in time (Robinson et al., 1996).
· In chemical terminology, less self-associated water has a greater chemical potential than more self associated water.
· This is why water ice with a complete crystalline network is less dense than liquid water and floats upon unfrozen water, a phenomenon with profound environmental impact.
· Water is amphoteric in this sense because, as illustrated in Figs. 1A and 1D, it can simultaneously share and donate electron density. Hydrogen atoms (the Lewis acids) on one or more adjacent water molecules can accept electron density from the unshared electron pairs on the oxygen atom (the Lewis bases) of another water molec ...
Enhancing Performance with Globus and the Science DMZGlobus
ESnet has led the way in helping national facilities—and many other institutions in the research community—configure Science DMZs and troubleshoot network issues to maximize data transfer performance. In this talk we will present a summary of approaches and tips for getting the most out of your network infrastructure using Globus Connect Server.
PHP Frameworks: I want to break free (IPC Berlin 2024)Ralf Eggert
In this presentation, we examine the challenges and limitations of relying too heavily on PHP frameworks in web development. We discuss the history of PHP and its frameworks to understand how this dependence has evolved. The focus will be on providing concrete tips and strategies to reduce reliance on these frameworks, based on real-world examples and practical considerations. The goal is to equip developers with the skills and knowledge to create more flexible and future-proof web applications. We'll explore the importance of maintaining autonomy in a rapidly changing tech landscape and how to make informed decisions in PHP development.
This talk is aimed at encouraging a more independent approach to using PHP frameworks, moving towards a more flexible and future-proof approach to PHP development.
SAP Sapphire 2024 - ASUG301 building better apps with SAP Fiori.pdfPeter Spielvogel
Building better applications for business users with SAP Fiori.
• What is SAP Fiori and why it matters to you
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• How to get started with SAP Fiori today
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• How SAP Build Code includes SAP Fiori tools and other generative artificial intelligence capabilities
• How SAP Fiori paves the way for using AI in SAP apps
The Metaverse and AI: how can decision-makers harness the Metaverse for their...Jen Stirrup
The Metaverse is popularized in science fiction, and now it is becoming closer to being a part of our daily lives through the use of social media and shopping companies. How can businesses survive in a world where Artificial Intelligence is becoming the present as well as the future of technology, and how does the Metaverse fit into business strategy when futurist ideas are developing into reality at accelerated rates? How do we do this when our data isn't up to scratch? How can we move towards success with our data so we are set up for the Metaverse when it arrives?
How can you help your company evolve, adapt, and succeed using Artificial Intelligence and the Metaverse to stay ahead of the competition? What are the potential issues, complications, and benefits that these technologies could bring to us and our organizations? In this session, Jen Stirrup will explain how to start thinking about these technologies as an organisation.
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
Generative AI Deep Dive: Advancing from Proof of Concept to ProductionAggregage
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In his public lecture, Christian Timmerer provides insights into the fascinating history of video streaming, starting from its humble beginnings before YouTube to the groundbreaking technologies that now dominate platforms like Netflix and ORF ON. Timmerer also presents provocative contributions of his own that have significantly influenced the industry. He concludes by looking at future challenges and invites the audience to join in a discussion.
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Iq3415931597
1. Biswajit Bera / International Journal of Engineering Research and Applications
(IJERA) ISSN: 2248-9622 www.ijera.com
Vol. 3, Issue 4, Jul-Aug 2013, pp.1593-1597
1593 | P a g e
Mechanism of Boundary Lubrication and Wear of Frictionless
Synovial Joint
Biswajit Bera
Department of Mechanical Engineering, NIT, Durgapur, India
Abstract
The natural synovial joints have excellent
lubricating ability to provide very low frictional
resistance and high wear resistance during various
activities of human being. Synovial fluid is having
mainly constituents of glycoproteins and
phospholipids. Albumin adsorbs over globulin by
hydrophobic bonding after formation of globulin
coating on hydrophilic cartilage surface and
phosphatidylcholine adsorbs over hydrophilic
surface of albumin by the formation of
phospholipid bilayer. Different interface of
adsorbed proteins and phospholipids layer
produces very low shear stress and produces the
synovial joint highly slippery and frictionless. Still,
synovial joints are effected by Osteoarthritis due
to degeneration of cartilage surface. Due to very
very slippery boundary lubrication of synovial
joint, abrasive and adhesive sliding wear of
cartilage surface is not possible. Present study
describes the damage mechanism of articular
cartilage on the basis of asperity fatigue model. As
knee joint bear much more load than that of hip
joint during walking, knee joint is early effected in
Osteoarthritis. As gradually, cartilage surface
detoriates loosing ultimate strength and modulus
of elasticity, wear rate increases with aging of
human being. It indicates ultimate result of
Osteoarthritis at old age.
Keyword: Synovial joint, Boundary lubrication,
Asperity fatigue wear, Osteoarthritis
I. Introduction
Synovial joint is an amazing mechanical
bearing created by God. The bone ends are covered
with articular cartilage within the synovial joint. The
synovial joint is sealed from the surrounding tissues
by the synovial membranes and the cavity is filled
with synovial fluid. The main purpose of the end
surface is to generate very good lubrication producing
very low frictional resistance so that subchondral
bone could be saved from early damage due to
excessive wear of bone to bone contact. According to
Charnley, animal joints have very low coefficient of
friction of the order of 10-3
[ 1 ] and very low
frictional surface of the synovial joint can be
compared as skating over icy surface. However,
synovial joint of human being produces rolling
motion to perform different common activity like
sitting, walking and running etc. Generally, during
rolling motion of a wheel on rough surface, friction
force is generated at the interface which produces
translation of the wheel and torque produces
rotational motion of the wheel. Now, as interface of
cartilage contact is highly slippery and almost
frictionless, as usual conventional rolling motion is
not possible in any synovial joint. So, cross connected
ligaments and muscles of any synovial joint produces
rolling motion ( articulation ) satisfying principle of
four bar mechanism which happens prominently, in
knee joint [ 2 ]. So, highly slippery lubrication of any
synovial joint is possible only by boundary lubrication
of synovial fluid. First, McCutchen postulated that
when two joint surfaces are compressed together,
porous cartilage surface weeps (exudes) fluid which
behave as a boundary lubricant. They showed that
when small specimens of articular cartilage were
rubbed against glass in presence of synovial fluid, the
co-efficient of friction was lower than in presence of
water [ 3 ]. W H Davis et al. have postulated that
lubricating glycoprotein (LGP) is adsorbed to the
surface and reduction in surface shear accomplished
by formation of hydration shells about the polar
surface of the adsorbed LGP creating thin layer of
viscous structured water at the surface [ 4 ]. Hill have
hypothesized that phospholipid, phosphatidylcholine
have better lubricating property and it becomes
surface active phospholipid after binding with mobile
Ca2+ and it will adsorbed with negatively charged
proteoglycans of the cartilage [ 5 ]. T Murakami et al.
have reported the phospholipid, phosphatidylcholine
of 0.01 g/dl as physiological concentration and
gamma globulin of 1.0g/dl at higher concentration
than the physiological level is effective in lower
frictional resistance of the synovial joint. The
adsorbed film and underlying gel film of proteoglycan
have protective roles against severe loading [ 6 ]. M
H Naka etall. have reported that water content and
substances present on the articular surface play an
important role in lubrication through the formation of
a layer with a high water content (hydrated layer) [ 7
]. The mode of boundary lubrication with integration
of lubricating effects of all synovia constituents,
phosphatidylcholine, albumin, and, gamma globulin is
not yet done to understand good boundary lubricating
ability of synovial fluid over articular cartilage
surface.
As synovial joint is very slippery and
frictionless, so sliding wear of cartilage surface is not
2. Biswajit Bera / International Journal of Engineering Research and Applications
(IJERA) ISSN: 2248-9622 www.ijera.com
Vol. 3, Issue 4, Jul-Aug 2013, pp.1593-1597
1594 | P a g e
possible. Basic mechanism of cartilage wear could be
understood from mechanism of different mode of
wear. Abrasive wear mode is not possible as hardness
of matting surfaces of cartilages are not different.
Wear from cartilage rubbing against cartilage surfaces
is not the result of adhesive wear mode since cartilage
surface do not cold weld together like metal surfaces
when their micro-asperities come in contact. So, there
is only possibility of fatigue wear mode of cartilage
surface by physiological cyclic compressive joint
loading. B B Seedhom has hypothesized that cartilage
is living tissue, the threshold at which it fails by either
mechanism of high stress or fatigue are determined by
human activities and life style [ 8 ]. Triona
McCormack et al. postulated that the fatigue
mechanism of cartilage induces truama in the
cartilage causing a weakening of interfibril
connections which link collagen fibril in the matrix,
leading to reduction in tensile strength [ 9 ]. Still now,
fatigue mechanism of cartilage in vivo is not yet
reported elsewhere. On the other hand, A Wang et al.
have investigated early wear of UHMWPE of
artificial joints by microscopic asperity fatigue
mechanism considering cyclic tangential motion
under constant normal load [ 10 ]. However, as
natural joint provides excellent lubrication ( <
0.005), so, only, cyclic tangential motion could not be
effective in the asperity fatigue mechanism of
cartilage surface in vivo due to very low frictional
resistance. Here, asperity fatigue of cartilage surface
in vivo is considered to occur due to cyclic loading
and unloading of Hertzian contact zone by
compressive normal load during articulation of a
synovial joints.
II. Theoretical mechanism and
formulation
2.1 Mechanism of boundary lubrication
Synovial fluid is a protein-lipid colloidal
solution and it’s main boundary lubricating
constituents are Albumin, globulin and
phosphatidylcholine those maintain colloidal stability
through their mutual interaction. Phosphatidylcholine
is a natural phospholipid that is available in Soyabin
oil. When the phopholipids are exposed to water of
synovial fluid, they arrange themselves into a
spherical two-layer sheet (a bilayer) with all of their
tails pointing toward the centre of the sheet. This
assembly process is similar to the coalescing of oil
droplets in water and is driven by the same force,
called the hydrophobic effect. On the other hand, at
the molecular level, the hydrophobic effect is
important in driving protein folding and aggregation
in water. So, Albumin would aggregate with
Globulin by hydrophobic bonding producing
glycoprotein gel in synovial fluid. So, through mutual
interaction of phospholipids bilayer and glycoprotein
gel, the protein gel would be encapsulated by
spherical phospholipids bilayer like cell membrane [
15 ] producing colloidal stability in synovial fluid.
Now, during rolling or articulation of synovial joint
under compressive loading, localized protein-lipid
adsorption occurs on hydrated cartilage surface.
Mechanism of protein adsorption could be explained
from nature of end group and secondary structure of
proteins. According to CD spectroscopy, BSA is
mainly construct from helix structure (60-67%) and
globulin is constructed from sheet structure [ 11 ].
Also, It is known that when protein adsorbs to a
surface, it’s a helix structure changes to random coil
and/or sheet structure [ 12 ]. So, in between synovia
glycoprotein, albumin and globulin, as globulin is
constructed of sheet secondary structure, so,
naturally, it will adsorb first onto cartilage surface by
strong hydrophilic bonding as a coating layer initially.
Due to high shear strength of globulin [ 12 ], it will
form a very rigid beta sheets layer over
microscopically, rough surface of cartilage [ 13 ] and
during articulation of synovial joint under
compressive loading, the asperities of cartilage
surface will be deformed gradually through globulin
coating. However, Secondly, albumin will adsorb
over coated globulin by natural hydrophobic
bonding due to presence of more number of
hydrophobic group of albumin. Experimentally, it is
observed that both of the protein, albumin and
globulin prefer to adsorb by hydrophobic bonding and
it is reviewed by M Malmsten also that most proteins
tend to adsorb more extensively at hydrophobic than
hydrophilic protein surfaces due to more limited
exchange at hydrophobic interaction [ 14 ]. Albumin
will form separate protein layer over globulin.
Thereafter, phosphatidylcholine of synovial fluid will
be adsorbed on hydrophilic surface of albumin by
hydrophilic bonding through formation of
phospholipid bilayer.
2.2 Asperity fatigue wear of cartilage surface
According to Greenwood and Williamson
model, two rough flat surfaces could be represented
by an equivalent rough surface in contact with a
smooth flat surface [ 17 ]. Similarly, the contact
between two rough spheres can be analyzed by a
physical model of a rough sphere with equivalent
radius of both spheres pressed against a smooth flat
surface. Generally, rolling occurs in any synovial joint
under normal compressive loading and Hertzian
contact zone of cartilage surface is repeatedly loaded
and unloaded. Due to normal cyclic loading and
unloading on Hertzian contact zone, asperities
deformation of spherical cartilage surface will be
elastic, plastic and elastic-plastic with bulk
deformation of curve cartilage surface. Let n number
asperities will be plastically deformed within Hertzian
contact zone. Due to cyclic loading and unloading,
fatigue strength of asperities will fall down
exponentially. When fatigue strength ( u
) of a
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1595 | P a g e
asperity equals to Hertzian contact pressure ( p ), a
hemispherical wear particle will be formed from tip of
the asperity ( as considered in adhesive wear law ).
So, py u
or,
u
p
y
(1)
where, y is the fatigue strength factor, which
determine the number of wear particles formation.
Let, x fraction of n umber of plastically deformed
asperities will produce x.n number of wear particle
from the elementary Hertzian contact area and volume
of wear particle is pv .
So, elementary wear volume is proportional to
number of wear particles volume of wear particle
pxnvdV
As number of plastically deformed asperities
increases with increment of Hertzian contact area so,
n dA and from the equation (1), it implies that
number of wear particle increases with increment of
fatigue strength fator, so, x y
Now, pydAvdV
Substituting, value of y in the above equation taking
from eqn
(1), it is obtained
p
u
dAv
p
dV
(2)
Volume of asperity deformation over curve cartilage
surface would be proportional with bulk deformation
of curve cartilage surface because merging of
asperities beside asperities would occur.
Simultaneously, the volume of asperity deformation
over curve cartilage surface would be inversely
proportional with surface roughness as tendency of
merging of asperities beside asperities would occur
much more if surface roughness is small. So, volume
of a hemispherical wear particle from asperity tip
under Hertzian cyclic fatigue loading could be written
as follows.
So, 2
3
p
a
v
(3)
Now, elementary wear volume could be obtained by
substituting value of eqn
(3) in eqn
(2)
pdA
a
dV 2
u
3
So, total volume of wear of curve cartilage surface
under Hertzian constant compressive loading (ie a =
Const)
A
2
u
3
pdA
a
V
2
2
u
N
K
R
(4)
This is the generalized expression for asperity fatigue
wear volume of cartilage for a synovial Joints.
III. Results and Discussion
3.1 Boundary lubrication
K Nakashima et al. have hypothesized that
1:2 ratio of glycoproteins, albumin and globulin,
constituted synergistic adsorb film for wear reduction
of PVA surface under severe loading condition and
has reported that equal (1:1) ratio of synovia
glycoproteins forms separate protein layer of albumin
over globulin producing very high wear rate [ 16 ].
It indicates that adsorption albumin on globulin is
the only possibility to produce very low boundary
friction on cartilage surface of synovial joint. Hill
have hypothesized that only surface active
phopholipid, phosphatidylcholine is a very good
boundary lubricant of synovial joint producing low
frictional resistance [ 5 ]. Also, T Murakami et al.
have reported the observation from pendulum test of
porcine shoulder joint. The phosphatidylcholine of
0.01 g/dl as physiological concentration and
globulin of 1.0g/dl at higher concentration than the
physiological level were effective in lower frictional
resistance of the synovial joint [ 6 ]. So the
phosphatidylcholine have better boundary lubricating
property of synovial joint due to weak hydrophobic
bonding of the phospholipid bilayer. Afterall,
boundary lubrication phenomenon of synovial fluid
resembles with boundary lubrication of lamellate
Graphite. Hydrophobic bonding of adsorbed
glycoproteins bilayer and phospholipids bilayer (like
bonding of Graphite lamellae layer) are weak shearing
interface producing very good boundary lubricating
ability of synovial fluid.
3.2 Osteoarthritic cartilage damage
From the final expression of wear volume, it
imply that wear volume of cartilage surface linearly
depends upon dimensional parameters of joint, radius
of bone end ( R ), inversely depends material
properties parameters of cartilage, modulus of
elasticity and ultimate strength of articular cartilage (
K and u
), and square of rms surface roughness of
the cartilage ( σ2
), and linearly proportional with
square of value of compressive normal joint contact
force ( N2
). For a particular subject, material
properties parameters, and surface roughness of
cartilage could be considered as constant, so,
characteristic of fatigue wear of cartilage surface
could be understood from the variation of dimensional
parameters of and value of compressive normal load
of the synovial joint. Generally, lower limb’s synovial
joints are affected by Osteoarthritis due to cyclic
compressive and tensile loading during human
walking. In reality, as knee joint works under more
load than hip joint during normal human walking [ 18
] , it is expected that elastic superfacial layer of knee
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Vol. 3, Issue 4, Jul-Aug 2013, pp.1593-1597
1596 | P a g e
cartilage will wear out early than that of hip joint.
Possibly, that is why, knee cartilage surface is extra
protected by meniscus layer whereas hip cartilage
surface have no need of such layer. So, meniscus
layer over knee cartilage surface plays very important
role to protect the joint from osteoarthritis. If
somehow, it is damaged early by any unwanted
accident, then the knee cartilage surface will wear out
very early period of time unexpectedly. In this regard,
it should be noted also that obesity, defined as being
20% over one's healthy weight, places people
(particularly women) at increased risk for
osteoarthritis due to increment of normal joint
loading. However, due to gradual loss of articular
cartilage by normal fatigue loading, its material
parameters, strength and modulus of elasticity will fall
down causing further fast wear rate of cartilage
surface with aging of human being. Now, the gradual
loss of tide superfacial layer cartilage surface
ultimately, causes Osteoarthritis of the any synovial
joint. After complete loss of tide superfacial layer
where collagen fibers are oriented tangentially,
middle layer of cartilage surface would be exposed.
Thereafter, randomly oriented collagen fibers of
cartilage middle layer would be gradually opened by
interstitial fluid pressure during cyclic Heartzian
compressive loading and eventually, it leads to
Osteoarthritis of the synovial joint.
IV. Conclusion
Theoretical mechanism of boundary
lubrication explains why synovial joints are so
slippery and almost frictionless. Mainly adsorption of
Albumin over Gamma globulin after formation of
globulin coating on hydrophilic cartilage surface
produces very very low shear stress and it is enhanced
by effect of phospholipids. Abrasive and adhesive
sliding wear are not possible causing any wear of
frictionless cartilage surface. Asperity fatigue wear of
cartilage surface under Heatzian cyclic fatigue
compressive joint loading produces gradual loss of
tide superfacial layer of cartilage surface and
eventually, middle layer of cartilage surface is
exposed. And gradually, it is opened by interstitial
fluid pressure cyclic compressive loading and
resulting Osteoarthritis of the synovial joint.
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