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Introduction to
Meta-analysis
Youngjun Na, PhD
Github: https://github.com/youngjunna
Email: ruminoreticulum@gmail.com
A three minute primer on meta-analysis
▪ https://www.youtube.com/watch?v=i675gZNe3MY
What is meta-analysis?
▪ Meta‐analysis is the process of combining data from multiple studies with the
goal of better estimating the true effect of a specific intervention or exposure on
a particular outcome.
Why performed a meta-analysis?
▪ Because the narrative review is based on discrete reports from a series of studies,
▪ it provides no real mechanism for synthesizing the data.
▪ By contrast, in a meta-analysis we introduce two fundamental changes.
▪ 1) Meta-analysis work directly with the effect size from each study rather than
the p-value.
▪ 2) Meta-analysis include all of the effects in a single statistical synthesis.
Effect size (ES) = Standardized Mean Difference (SMD)
Forest plot
▪ Forest plot is a graphical display of estimated results from a meta-analysis.
Publication bias
▪ Publication bias is a type of bias that occurs in published academic research.
▪ If the result showed positive effect -> easy to publication
▪ BUT, If the result showed negative effect -> NOT easy to publication -> remains
the data in the hard-disk… orz
▪ It can be determined using funnel plot.
Thank you
Q&A

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Introduction to meta-analysis

  • 1. Introduction to Meta-analysis Youngjun Na, PhD Github: https://github.com/youngjunna Email: ruminoreticulum@gmail.com
  • 2. A three minute primer on meta-analysis ▪ https://www.youtube.com/watch?v=i675gZNe3MY
  • 3. What is meta-analysis? ▪ Meta‐analysis is the process of combining data from multiple studies with the goal of better estimating the true effect of a specific intervention or exposure on a particular outcome.
  • 4. Why performed a meta-analysis? ▪ Because the narrative review is based on discrete reports from a series of studies, ▪ it provides no real mechanism for synthesizing the data. ▪ By contrast, in a meta-analysis we introduce two fundamental changes. ▪ 1) Meta-analysis work directly with the effect size from each study rather than the p-value. ▪ 2) Meta-analysis include all of the effects in a single statistical synthesis.
  • 5. Effect size (ES) = Standardized Mean Difference (SMD)
  • 6. Forest plot ▪ Forest plot is a graphical display of estimated results from a meta-analysis.
  • 7.
  • 8. Publication bias ▪ Publication bias is a type of bias that occurs in published academic research. ▪ If the result showed positive effect -> easy to publication ▪ BUT, If the result showed negative effect -> NOT easy to publication -> remains the data in the hard-disk… orz ▪ It can be determined using funnel plot.
  • 9.