This document provides information about a themed competition focused on identifying innate response targets for medical countermeasures against biological threats. The competition seeks innovative proposals to identify new cellular or host pathway targets, candidate therapies, or platform technologies. Proposals should explore modulating the host response through cellular targets and pathways in a generic way applicable to multiple threats. Successful projects will work with a technical partner and may receive follow-on funding to further develop technologies of interest to defence.
This document provides information about an Innovation Network event hosted by the Defence Science and Technology Laboratory (DSTL) on February 10, 2016. It discusses DSTL's Centre for Defence Enterprise (CDE), which aims to foster innovation in defence and security technologies. The CDE funds early-stage research projects through competitions in various themes. It has provided over £69 million in funding to over 1000 projects since its inception. The document outlines some of CDE's current and upcoming competitions in areas like synthetic biology, autonomous systems, and military challenges. It also discusses challenges around developing new adhesives, corrosion resistance, and erosion protection through synthetic biology approaches.
Presentation slides from CDE themed competition launch. For full details of this competition see: http://www.science.mod.uk/events/event_detail.aspx?eventID=258
The National Guard Chemical, Biological, Radiological, Nuclear and high-yield explosive Enhanced Response Force Package (CERFP) provides immediate response to CBRN incidents. It is comprised of five operational elements that include search and extraction, decontamination, medical care, fatality recovery, and command and control. The CERFP's mission is to conduct search and rescue operations, decontaminate casualties, provide medical treatment, and recover fatalities in order to assist local authorities in responding to CBRN incidents. There are 17 fully operational CERFP teams located across the 10 FEMA regions.
The document announces a themed competition hosted by the Centre for Defence Enterprise (CDE) to develop future sonar technology. It outlines three challenges seeking proposals: 1) harnessing discovery for sonar advantage, 2) measuring decision effectiveness of new sonar technologies, and 3) improving non-destructive evaluation of sonar equipment. Successful proposals will receive initial funding up to £850k and may qualify for additional long-term funding to further mature their solutions. The deadline for submissions is May 29, 2014.
FY 2013 R&D REPORT January 6 2014 - Department of Homeland SecurityLyle Birkey
The Department of Homeland Security (DHS) was established in 2003 to protect the US from threats. It oversees environmental research and development through two main divisions - the US Coast Guard and Science & Technology Directorate. The Coast Guard conducts environmental R&D related to its missions of protecting resources and responding to pollution. The Science & Technology Directorate manages research to strengthen security and resiliency through knowledge and innovative technologies. DHS also coordinates with national laboratories and research centers to develop capabilities against biological and agricultural threats.
Presentations from 9 July 2015 Innovation Network event. For more information see: https://www.gov.uk/government/news/cde-innovation-network-event-9-july-2015-london
This document provides information about an Innovation Network event hosted by the Defence Science and Technology Laboratory (DSTL) on February 10, 2016. It discusses DSTL's Centre for Defence Enterprise (CDE), which aims to foster innovation in defence and security technologies. The CDE funds early-stage research projects through competitions in various themes. It has provided over £69 million in funding to over 1000 projects since its inception. The document outlines some of CDE's current and upcoming competitions in areas like synthetic biology, autonomous systems, and military challenges. It also discusses challenges around developing new adhesives, corrosion resistance, and erosion protection through synthetic biology approaches.
Presentation slides from CDE themed competition launch. For full details of this competition see: http://www.science.mod.uk/events/event_detail.aspx?eventID=258
The National Guard Chemical, Biological, Radiological, Nuclear and high-yield explosive Enhanced Response Force Package (CERFP) provides immediate response to CBRN incidents. It is comprised of five operational elements that include search and extraction, decontamination, medical care, fatality recovery, and command and control. The CERFP's mission is to conduct search and rescue operations, decontaminate casualties, provide medical treatment, and recover fatalities in order to assist local authorities in responding to CBRN incidents. There are 17 fully operational CERFP teams located across the 10 FEMA regions.
The document announces a themed competition hosted by the Centre for Defence Enterprise (CDE) to develop future sonar technology. It outlines three challenges seeking proposals: 1) harnessing discovery for sonar advantage, 2) measuring decision effectiveness of new sonar technologies, and 3) improving non-destructive evaluation of sonar equipment. Successful proposals will receive initial funding up to £850k and may qualify for additional long-term funding to further mature their solutions. The deadline for submissions is May 29, 2014.
FY 2013 R&D REPORT January 6 2014 - Department of Homeland SecurityLyle Birkey
The Department of Homeland Security (DHS) was established in 2003 to protect the US from threats. It oversees environmental research and development through two main divisions - the US Coast Guard and Science & Technology Directorate. The Coast Guard conducts environmental R&D related to its missions of protecting resources and responding to pollution. The Science & Technology Directorate manages research to strengthen security and resiliency through knowledge and innovative technologies. DHS also coordinates with national laboratories and research centers to develop capabilities against biological and agricultural threats.
Presentations from 9 July 2015 Innovation Network event. For more information see: https://www.gov.uk/government/news/cde-innovation-network-event-9-july-2015-london
This document summarizes a webinar presented by the Centre for Defence Enterprise (CDE) on funding opportunities for research on innate host response targets for therapy against biothreat agents. The CDE is launching a themed competition seeking short proof-of-concept proposals in three challenge areas: 1) Identification of new cellular or host pathway targets, 2) Identification of new candidate therapies, and 3) Identification of new platform technologies for assessing therapeutic benefit. Successful proposals will receive up to £80,000 in funding and may qualify for additional follow-on funding to further develop technologies of interest to the UK Ministry of Defence. The competition aims to fund highly innovative early-stage research with potential military and civilian applications.
The document discusses the UK's chemical, biological, radiological and nuclear (CBRN) protection capabilities and challenges. It notes that terrorism and state threats involving CBRN weapons are top national security risks. The UK's policy is for armed forces to be able to "survive and operate" in all CBRN environments, but current capabilities to detect and treat CBRN hazards remain difficult. Various projects are underway to improve protection, but continued investment is needed to address this evolving threat.
Slides from launch event on 16 July 2013 for CDE themed call for research proposals. For full details of this call see: http://www.science.mod.uk/events/event_detail.aspx?eventid=260
The document summarizes key aspects of Health Service Support operations from MCWP 4-11.1 chapters 1, 2, and 4. It discusses the mission to minimize effects of wounds and disease, forms of threat as enemy casualties and disease/non-battle injuries. It outlines casualty care management and functional areas medical plans must address. The document also summarizes intelligence sources and logistics considerations including allowance, resupply, and disposal of materials.
- The document discusses the multi-disciplinary approach needed to prevent and control the COVID-19 outbreak, which involves combining knowledge and skills from various disciplines like public health, nursing, medicine, and more.
- Key aspects of the multi-disciplinary approach include clear goals, defined roles for each discipline, effective communication, and measurable processes and outcomes. Principles that guide the approach are situation awareness, inter-sectoral coordination, and adherence to core disease response capacities.
- Strategic approaches discussed include surveillance at points of entry, containment of local clusters, implementing mitigation measures during a large outbreak, and a programmatic approach should COVID-19 become endemic. Working closely with states involves oversight, sharing of plans and guidelines
This document discusses the problem of increasing antimicrobial resistance and outlines strategies for antimicrobial stewardship programs. It recognizes antimicrobial resistance as a serious global problem that requires immediate action. Antimicrobial stewardship is defined as optimizing antibiotic use through selecting appropriate treatment duration, dose, and spectrum of coverage. The document recommends establishing multidisciplinary stewardship teams and implementing interventions like guidelines, audit and feedback, and streamlining of therapy to improve antibiotic use and slow the development of resistance. Physicians are identified as key players that can help address the problem through their antibiotic prescribing practices.
This document discusses several topics related to human performance as it relates to defense and security. It addresses themes like systems interface, survivability, sustainment, training and education, and medical sciences. It discusses how human performance will be intrinsic to future force capabilities and how defense personnel will achieve a symbiotic relationship with technology. It also summarizes research areas like combat casualty care, medical systems and logistics, simulation for training and education, and mental health. The document emphasizes that people are central to delivering military capability and that provision of capable, trained personnel is critical to operational success.
ECDC supports preparedness efforts in three main ways:
1. By identifying and disseminating best practices in preparedness planning through literature reviews, case studies, and tools.
2. By building national preparedness capacities through workshops, training, and supporting the development of specific capabilities.
3. By fostering interoperability between country preparedness plans and promoting multi-sectoral cooperation to address cross-border health threats.
Presentation slides from CDE themed call launch event on 25 June - for full details of this call see: http://www.science.mod.uk/events/event_detail.aspx?eventid=259
This document discusses reducing the burden of noise-induced hearing loss and tinnitus in military personnel. It outlines the Defence Medical Services' research strategy to prioritize prevention, early detection, and treatment of hearing loss. The strategy aims to sustain military capability by protecting hearing and quality of life. The document advertises a competition seeking disruptive ideas that can detect hearing damage earlier, slow or reverse established hearing loss, and limit further harm through prevention methods like protective equipment or drugs. The goal is to shift focus from managing disability to preempting and intervening on hearing deterioration.
1. Graham Love discusses the development of personalized medicine in Ireland from the perspective of the Health Research Board.
2. While some personalized cancer care exists, moving towards personalized medicine research requires large-scale sequencing efforts and clinical trials to validate biomarkers and treatments.
3. For personalized medicine to become a true revolution, there needs to be greater efforts to educate decision-makers and the general public about what personalized medicine is and its potential benefits.
The document discusses approaches to tackling antimicrobial resistance (AMR) through research funding and collaboration. It outlines that the Medical Research Council (MRC) leads a cross-council initiative in the UK to fund AMR research across four themes. The MRC also coordinates an AMR Funders Forum and the Joint Programming Initiative on AMR to strategically support the field. Current funding includes a £40 million commitment for multidisciplinary AMR research projects and international partnerships through programs like Newton Fund.
Dr. Graham Love, CEO, Health Research BoardInvestnet
- Research active hospitals had lower risk-adjusted mortality rates even after adjusting for staffing and structural factors, showing the benefits of clinical research.
- Healthcare is a knowledge industry but expectations are rising faster than resources, requiring smarter use of resources and greater self-learning capacity through research.
- The Health Research Board invests over €200 million between 2010-2014, with the largest areas being disease management, treatment evaluation, and health services research.
- Actions are outlined to speed up hospital approvals for studies, encourage more research via clinical research facilities, and involve research in upcoming health system strategies and multi-site feasibility and full studies.
Enhanced Recovery After Surgery (ERAS®) is the Enhanced Recovery After Surgery (ERAS®) is the implementation of patient-focused, standardized, evidencefocused, standardized, evidencefocused, standardized, evidencefocused, standardized, evidencefocused, standardized, evidencefocused, standardized, evidence-based, interdisciplinary perioperative guidelines.
Learn more about Enhanced Recovery Canada:
http://ow.ly/hR3j30jsnjR
The document provides details about an upcoming learning series on anticipatory action and cash. It includes an agenda with 3 sessions over 3 weeks that will discuss theories of anticipatory action and cash, examples of cash in early action protocols, and using cash in contingency plans for imminent crises. Session 1, which is summarized here, includes an introduction to facilitators and presentations on cash-based programming theory, anticipatory action theory including disaster risk management, and the potential to include cash-based approaches in anticipatory action.
The document discusses risk assessment requirements and strategies for conducting risk assessments in a less prescriptive regulatory environment. It outlines the need to conduct overarching, local, medical surveillance, emergency response, and communication risk assessments. Local risk assessments require identifying hazards, likelihood of occurrence, and consequences for specific experimental protocols. Considerations for viral vector systems include potential for replication-competent viruses and effects of foreign proteins. A less prescriptive approach requires more documentation to justify flexibility in work environments and procedures.
The Department for International Trade helps UK businesses export, especially in the defense, security, and cybersecurity sectors. It works with these industries and other government departments to promote UK capabilities abroad, build relationships with overseas buyers, and support key export opportunities. The DIT also led a strategy exercise with industry to define how the UK government will support the security sector in exporting from 2019-2024. This new strategy focuses on using all of the UK government's capabilities to help companies export in a collaborative way.
The document summarizes research and development efforts in the UK fire service. It describes the national structure which includes a national lead, regional leads across 11 regions, and support from 50 UK fire and rescue services. It works closely with various partners from government, industry, academia, and other emergency services. The approach covers fundamental, industrial, and capability development research. Key partners include various government defense and security organizations, universities, the fire industry association, and international partners through IFAFRI. It conducts surveys to identify emerging research needs and aims to map out fire and rescue related research. Future plans include more horizon scanning, capability analysis, and challenges to access science and technology assets.
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This document summarizes a webinar presented by the Centre for Defence Enterprise (CDE) on funding opportunities for research on innate host response targets for therapy against biothreat agents. The CDE is launching a themed competition seeking short proof-of-concept proposals in three challenge areas: 1) Identification of new cellular or host pathway targets, 2) Identification of new candidate therapies, and 3) Identification of new platform technologies for assessing therapeutic benefit. Successful proposals will receive up to £80,000 in funding and may qualify for additional follow-on funding to further develop technologies of interest to the UK Ministry of Defence. The competition aims to fund highly innovative early-stage research with potential military and civilian applications.
The document discusses the UK's chemical, biological, radiological and nuclear (CBRN) protection capabilities and challenges. It notes that terrorism and state threats involving CBRN weapons are top national security risks. The UK's policy is for armed forces to be able to "survive and operate" in all CBRN environments, but current capabilities to detect and treat CBRN hazards remain difficult. Various projects are underway to improve protection, but continued investment is needed to address this evolving threat.
Slides from launch event on 16 July 2013 for CDE themed call for research proposals. For full details of this call see: http://www.science.mod.uk/events/event_detail.aspx?eventid=260
The document summarizes key aspects of Health Service Support operations from MCWP 4-11.1 chapters 1, 2, and 4. It discusses the mission to minimize effects of wounds and disease, forms of threat as enemy casualties and disease/non-battle injuries. It outlines casualty care management and functional areas medical plans must address. The document also summarizes intelligence sources and logistics considerations including allowance, resupply, and disposal of materials.
- The document discusses the multi-disciplinary approach needed to prevent and control the COVID-19 outbreak, which involves combining knowledge and skills from various disciplines like public health, nursing, medicine, and more.
- Key aspects of the multi-disciplinary approach include clear goals, defined roles for each discipline, effective communication, and measurable processes and outcomes. Principles that guide the approach are situation awareness, inter-sectoral coordination, and adherence to core disease response capacities.
- Strategic approaches discussed include surveillance at points of entry, containment of local clusters, implementing mitigation measures during a large outbreak, and a programmatic approach should COVID-19 become endemic. Working closely with states involves oversight, sharing of plans and guidelines
This document discusses the problem of increasing antimicrobial resistance and outlines strategies for antimicrobial stewardship programs. It recognizes antimicrobial resistance as a serious global problem that requires immediate action. Antimicrobial stewardship is defined as optimizing antibiotic use through selecting appropriate treatment duration, dose, and spectrum of coverage. The document recommends establishing multidisciplinary stewardship teams and implementing interventions like guidelines, audit and feedback, and streamlining of therapy to improve antibiotic use and slow the development of resistance. Physicians are identified as key players that can help address the problem through their antibiotic prescribing practices.
This document discusses several topics related to human performance as it relates to defense and security. It addresses themes like systems interface, survivability, sustainment, training and education, and medical sciences. It discusses how human performance will be intrinsic to future force capabilities and how defense personnel will achieve a symbiotic relationship with technology. It also summarizes research areas like combat casualty care, medical systems and logistics, simulation for training and education, and mental health. The document emphasizes that people are central to delivering military capability and that provision of capable, trained personnel is critical to operational success.
ECDC supports preparedness efforts in three main ways:
1. By identifying and disseminating best practices in preparedness planning through literature reviews, case studies, and tools.
2. By building national preparedness capacities through workshops, training, and supporting the development of specific capabilities.
3. By fostering interoperability between country preparedness plans and promoting multi-sectoral cooperation to address cross-border health threats.
Presentation slides from CDE themed call launch event on 25 June - for full details of this call see: http://www.science.mod.uk/events/event_detail.aspx?eventid=259
This document discusses reducing the burden of noise-induced hearing loss and tinnitus in military personnel. It outlines the Defence Medical Services' research strategy to prioritize prevention, early detection, and treatment of hearing loss. The strategy aims to sustain military capability by protecting hearing and quality of life. The document advertises a competition seeking disruptive ideas that can detect hearing damage earlier, slow or reverse established hearing loss, and limit further harm through prevention methods like protective equipment or drugs. The goal is to shift focus from managing disability to preempting and intervening on hearing deterioration.
1. Graham Love discusses the development of personalized medicine in Ireland from the perspective of the Health Research Board.
2. While some personalized cancer care exists, moving towards personalized medicine research requires large-scale sequencing efforts and clinical trials to validate biomarkers and treatments.
3. For personalized medicine to become a true revolution, there needs to be greater efforts to educate decision-makers and the general public about what personalized medicine is and its potential benefits.
The document discusses approaches to tackling antimicrobial resistance (AMR) through research funding and collaboration. It outlines that the Medical Research Council (MRC) leads a cross-council initiative in the UK to fund AMR research across four themes. The MRC also coordinates an AMR Funders Forum and the Joint Programming Initiative on AMR to strategically support the field. Current funding includes a £40 million commitment for multidisciplinary AMR research projects and international partnerships through programs like Newton Fund.
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- Research active hospitals had lower risk-adjusted mortality rates even after adjusting for staffing and structural factors, showing the benefits of clinical research.
- Healthcare is a knowledge industry but expectations are rising faster than resources, requiring smarter use of resources and greater self-learning capacity through research.
- The Health Research Board invests over €200 million between 2010-2014, with the largest areas being disease management, treatment evaluation, and health services research.
- Actions are outlined to speed up hospital approvals for studies, encourage more research via clinical research facilities, and involve research in upcoming health system strategies and multi-site feasibility and full studies.
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The document discusses risk assessment requirements and strategies for conducting risk assessments in a less prescriptive regulatory environment. It outlines the need to conduct overarching, local, medical surveillance, emergency response, and communication risk assessments. Local risk assessments require identifying hazards, likelihood of occurrence, and consequences for specific experimental protocols. Considerations for viral vector systems include potential for replication-competent viruses and effects of foreign proteins. A less prescriptive approach requires more documentation to justify flexibility in work environments and procedures.
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The Department for International Trade helps UK businesses export, especially in the defense, security, and cybersecurity sectors. It works with these industries and other government departments to promote UK capabilities abroad, build relationships with overseas buyers, and support key export opportunities. The DIT also led a strategy exercise with industry to define how the UK government will support the security sector in exporting from 2019-2024. This new strategy focuses on using all of the UK government's capabilities to help companies export in a collaborative way.
The document summarizes research and development efforts in the UK fire service. It describes the national structure which includes a national lead, regional leads across 11 regions, and support from 50 UK fire and rescue services. It works closely with various partners from government, industry, academia, and other emergency services. The approach covers fundamental, industrial, and capability development research. Key partners include various government defense and security organizations, universities, the fire industry association, and international partners through IFAFRI. It conducts surveys to identify emerging research needs and aims to map out fire and rescue related research. Future plans include more horizon scanning, capability analysis, and challenges to access science and technology assets.
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Join us to learn how UiPath Apps can directly and easily interact with prebuilt connectors via Integration Service--including Salesforce, ServiceNow, Open GenAI, and more.
The best part is you can achieve this without building a custom workflow! Say goodbye to the hassle of using separate automations to call APIs. By seamlessly integrating within App Studio, you can now easily streamline your workflow, while gaining direct access to our Connector Catalog of popular applications.
We’ll discuss and demo the benefits of UiPath Apps and connectors including:
Creating a compelling user experience for any software, without the limitations of APIs.
Accelerating the app creation process, saving time and effort
Enjoying high-performance CRUD (create, read, update, delete) operations, for
seamless data management.
Speakers:
Russell Alfeche, Technology Leader, RPA at qBotic and UiPath MVP
Charlie Greenberg, host
Conversational agents, or chatbots, are increasingly used to access all sorts of services using natural language. While open-domain chatbots - like ChatGPT - can converse on any topic, task-oriented chatbots - the focus of this paper - are designed for specific tasks, like booking a flight, obtaining customer support, or setting an appointment. Like any other software, task-oriented chatbots need to be properly tested, usually by defining and executing test scenarios (i.e., sequences of user-chatbot interactions). However, there is currently a lack of methods to quantify the completeness and strength of such test scenarios, which can lead to low-quality tests, and hence to buggy chatbots.
To fill this gap, we propose adapting mutation testing (MuT) for task-oriented chatbots. To this end, we introduce a set of mutation operators that emulate faults in chatbot designs, an architecture that enables MuT on chatbots built using heterogeneous technologies, and a practical realisation as an Eclipse plugin. Moreover, we evaluate the applicability, effectiveness and efficiency of our approach on open-source chatbots, with promising results.
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...Alex Pruden
Folding is a recent technique for building efficient recursive SNARKs. Several elegant folding protocols have been proposed, such as Nova, Supernova, Hypernova, Protostar, and others. However, all of them rely on an additively homomorphic commitment scheme based on discrete log, and are therefore not post-quantum secure. In this work we present LatticeFold, the first lattice-based folding protocol based on the Module SIS problem. This folding protocol naturally leads to an efficient recursive lattice-based SNARK and an efficient PCD scheme. LatticeFold supports folding low-degree relations, such as R1CS, as well as high-degree relations, such as CCS. The key challenge is to construct a secure folding protocol that works with the Ajtai commitment scheme. The difficulty, is ensuring that extracted witnesses are low norm through many rounds of folding. We present a novel technique using the sumcheck protocol to ensure that extracted witnesses are always low norm no matter how many rounds of folding are used. Our evaluation of the final proof system suggests that it is as performant as Hypernova, while providing post-quantum security.
Paper Link: https://eprint.iacr.org/2024/257
Your One-Stop Shop for Python Success: Top 10 US Python Development Providersakankshawande
Simplify your search for a reliable Python development partner! This list presents the top 10 trusted US providers offering comprehensive Python development services, ensuring your project's success from conception to completion.
Skybuffer SAM4U tool for SAP license adoptionTatiana Kojar
Manage and optimize your license adoption and consumption with SAM4U, an SAP free customer software asset management tool.
SAM4U, an SAP complimentary software asset management tool for customers, delivers a detailed and well-structured overview of license inventory and usage with a user-friendly interface. We offer a hosted, cost-effective, and performance-optimized SAM4U setup in the Skybuffer Cloud environment. You retain ownership of the system and data, while we manage the ABAP 7.58 infrastructure, ensuring fixed Total Cost of Ownership (TCO) and exceptional services through the SAP Fiori interface.
Monitoring and Managing Anomaly Detection on OpenShift.pdfTosin Akinosho
Monitoring and Managing Anomaly Detection on OpenShift
Overview
Dive into the world of anomaly detection on edge devices with our comprehensive hands-on tutorial. This SlideShare presentation will guide you through the entire process, from data collection and model training to edge deployment and real-time monitoring. Perfect for those looking to implement robust anomaly detection systems on resource-constrained IoT/edge devices.
Key Topics Covered
1. Introduction to Anomaly Detection
- Understand the fundamentals of anomaly detection and its importance in identifying unusual behavior or failures in systems.
2. Understanding Edge (IoT)
- Learn about edge computing and IoT, and how they enable real-time data processing and decision-making at the source.
3. What is ArgoCD?
- Discover ArgoCD, a declarative, GitOps continuous delivery tool for Kubernetes, and its role in deploying applications on edge devices.
4. Deployment Using ArgoCD for Edge Devices
- Step-by-step guide on deploying anomaly detection models on edge devices using ArgoCD.
5. Introduction to Apache Kafka and S3
- Explore Apache Kafka for real-time data streaming and Amazon S3 for scalable storage solutions.
6. Viewing Kafka Messages in the Data Lake
- Learn how to view and analyze Kafka messages stored in a data lake for better insights.
7. What is Prometheus?
- Get to know Prometheus, an open-source monitoring and alerting toolkit, and its application in monitoring edge devices.
8. Monitoring Application Metrics with Prometheus
- Detailed instructions on setting up Prometheus to monitor the performance and health of your anomaly detection system.
9. What is Camel K?
- Introduction to Camel K, a lightweight integration framework built on Apache Camel, designed for Kubernetes.
10. Configuring Camel K Integrations for Data Pipelines
- Learn how to configure Camel K for seamless data pipeline integrations in your anomaly detection workflow.
11. What is a Jupyter Notebook?
- Overview of Jupyter Notebooks, an open-source web application for creating and sharing documents with live code, equations, visualizations, and narrative text.
12. Jupyter Notebooks with Code Examples
- Hands-on examples and code snippets in Jupyter Notebooks to help you implement and test anomaly detection models.
Freshworks Rethinks NoSQL for Rapid Scaling & Cost-EfficiencyScyllaDB
Freshworks creates AI-boosted business software that helps employees work more efficiently and effectively. Managing data across multiple RDBMS and NoSQL databases was already a challenge at their current scale. To prepare for 10X growth, they knew it was time to rethink their database strategy. Learn how they architected a solution that would simplify scaling while keeping costs under control.
Essentials of Automations: Exploring Attributes & Automation ParametersSafe Software
Building automations in FME Flow can save time, money, and help businesses scale by eliminating data silos and providing data to stakeholders in real-time. One essential component to orchestrating complex automations is the use of attributes & automation parameters (both formerly known as “keys”). In fact, it’s unlikely you’ll ever build an Automation without using these components, but what exactly are they?
Attributes & automation parameters enable the automation author to pass data values from one automation component to the next. During this webinar, our FME Flow Specialists will cover leveraging the three types of these output attributes & parameters in FME Flow: Event, Custom, and Automation. As a bonus, they’ll also be making use of the Split-Merge Block functionality.
You’ll leave this webinar with a better understanding of how to maximize the potential of automations by making use of attributes & automation parameters, with the ultimate goal of setting your enterprise integration workflows up on autopilot.
24. UNCLASSIFIED
Biological Agents
• Very low infectious dose
– Highly toxic
• Infectious via the inhalational route
• Cause endemic disease
• Usually zoonotic diseases
• Lethal or incapacitating
• BTWC has no schedules and no verification regime
28. UNCLASSIFIED
Regulations and Best Practise
• Dangerous Pathogens work conducted in accordance
with Health and Safety Executive
(ACDP/ACGM/COSHH) and DEFRA guidelines
• Animal studies conducted under licence by the Home
Office
29. UNCLASSIFIED
Vaccination
• Name derived from use of cowpox (Vaccinia) to protect against
smallpox
– Jenner 1796
– Pasteur 1881
• Suspension of dead, attenuated or otherwise modified micro-
organisms USED TO INDUCE IMMUNITY TO A DISEASE
– Stimulates immune system (e.g. antibodies)
– Induces memory
– Eradicates disease
The most cost effect way to treat infectious disease
31. UNCLASSIFIED
Antibiotics
• Not active against some bacteria
– Natural resistance
• Different antibiotics required for different agents
• Relapsing infection
• Trigger to treat required
• Compliance/Side effects
– 44% completed 60 day course during BA letter attacks
BUT
• Broad spectrum of activity
• No predefined threat spectrum
32. UNCLASSIFIED
CFI is a broad spectrum antibiotic effective
against multiple BW agents
• Treatment with encapsulated
ciprofloxacin effectively treats three
BW agents: F. tularensis, Y. pestis
and C. burnetii
• In collaboration with Health
Protection Agency, Defence
Research and Development
Canada and Aradigm Corporation
33. UNCLASSIFIED
Humanised Antibody for the Treatment of Venezuelan
Equine Encephalitis Virus (VEEV)
• No available licensed vaccines or
antivirals for treatment of VEEV
• A mouse monoclonal antibody is
effective for the treatment of
VEEV in a mouse model of
disease
• Humanised antibody produced to
reduce potential adverse
reactions in humans
– biologically active
– protects mice against lethal
VEEV challenge
0 5 25 50 75 100
0
20
40
60
80
100
Antibody (μg) Administered
PercentSurvival
Survival of BALB/c mice pre-treated with humanised
antibody before challenge with 100LD50 of VEEV
O'Brien LM et al, Virology. 2012,
Goodchild SA, et al, Antiviral Res. 2011
34. UNCLASSIFIED
Summary
• A flexible response is essential
• Vaccines provide excellent protection for those
immunised before exposure
• Post-exposure therapies provide a rapid response
capability against some agents
• Following a BW attack, and for some agents, it will be
necessary to use both post-exposure therapies and
vaccines
35. Innate response targets for therapy
CDE themed competition
March 25 - June 5 2014
31 March 2014