- Research active hospitals had lower risk-adjusted mortality rates even after adjusting for staffing and structural factors, showing the benefits of clinical research. - Healthcare is a knowledge industry but expectations are rising faster than resources, requiring smarter use of resources and greater self-learning capacity through research. - The Health Research Board invests over €200 million between 2010-2014, with the largest areas being disease management, treatment evaluation, and health services research. - Actions are outlined to speed up hospital approvals for studies, encourage more research via clinical research facilities, and involve research in upcoming health system strategies and multi-site feasibility and full studies.