Researchers at Boston Children's Hospital have developed lipidic oxygen-containing microparticles (LOMs) that can be injected intravenously to rapidly oxygenate the blood. The LOMs are composed of oxygen gas encapsulated in a lipid layer averaging 2-4 micrometers in size. When injected into the bloodstream of rabbits with low blood oxygen, the LOMs restored oxygen saturation to near-normal levels within seconds. The researchers hope these injectable oxygen microparticles could stabilize patients in emergency situations until more definitive treatments can be administered.

1. Presented By:
Aqsa Ayoub
Kinnaird
College For
Women
Lahore
INJECTING
LIFESAVING OXYGEN
INTO A VEIN

2.  Patients unable to breathe
because of acute lung failure
or an obstructed airway need
another way to get oxygen to
their blood -- and fast -- to
avoid cardiac arrest and brain
injury.
INTRODUCTION
 A team led by researchers at boston children's
hospital has designed tiny, gas-filled microparticles
that can be injected directly into the bloodstream to
quickly oxygenate the blood.
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3.  The scientist began investigating the idea of injectable
oxygen many years back , after caring for a little girl
who sustained a severe brain injury resulting from a
severe pneumonia that caused bleeding into her lungs
and severely low oxygen levels. Despite the team's best
efforts, she died before they could place her on a
heart-lung machine. Frustrated by this, he formed a
team to search for another way to deliver oxygen.
BACKGROUND
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4.  In the studies reported in the
paper, they used a device called
a sonicator, which uses high-
intensity sound waves to mix the
oxygen and lipids together.
 The process traps oxygen gas
inside particles averaging 2 to 4
micrometers in size . The
resulting solution, with oxygen
gas making up 70 percent of the
volume, mixed efficiently with
human blood.
MICROPARTICLE FORMATION
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5.  Lipidic oxygen-containing
microparticles (LOMs)
 They are composed of oxygen gas
pocketed in a layer of lipids, a
natural molecule that usually
stores energy or serves as a
component to cell membranes.
 Lipids can be waxes, some
vitamins, monoglycerides,
diglycerides, triglycerides,
phospholipids, or—as in this
case—fats.
WHAT THESE MICROPARTICLES ARE????
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6.  The LOMs solutions are
portable and could stabilize
patients in emergency
situations, buying time for
paramedics, emergency
clinicians or intensive care
clinicians to more safely place
a breathing tube or perform
other life-saving therapies,
LOM’S SOLUTIONS
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HOW THEY WORK…..

8. HOW THEY WORK………
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 After intravenous injection,
LOM suspensions mixed with
venous blood, which was then
oxygenated

9.  The check the effect of LOMs to blood, they desaturated
human red blood cells using nitrogen gas and
maintained them at 37°C under continuous motion on
stir plate. LOMs were added added to the sample
results indicate that the oxygen content of the blood
increased by about 1 ml for each milliliter of O2 gas
(encapsulated by LOMs) that was added to the blood
sample.
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EX VIVO ADMINISTRATION

10.  The LOMs solution was injected intravenously into
rabbits with low blood oxygen levels, which caused the
restoration of blood oxygen saturation within seconds
to near-normal levels.
 When the trachea was completely blocked – a more
dangerous “real world” scenario - these microparticles
kept the animals alive and reduced the incidence of
cardiac arrest and organ injury.
IN VIVO ADMINISRARTION
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11.  It sounds like magic, but it was just the start of what,
after years of investigation, became this real life-
giving liquid in a bottle.
 This is what the future is about. And it's a beautiful one
indeed, one that is arriving earlier than we ever could
have expected.
CONCLUSION
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12.  http://mediclopaedia.com/post/49449703562/oxygen-
microparticle-injections-the-microparticles
 http://nextbigfuture.com/2013_05_12_archive.html
 http://www.33rdsquare.com/2012/06/researchers-
develop-new-way-to-breath.html
REFERENCES
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Thank you