Down syndrome is a genetic disorder caused by the presence of an extra chromosome. It is one of the most common genetic causes of intellectual disabilities. Individuals with Down syndrome often have characteristic facial features including a flat nose, small ears, upward slanting eyes, and a single deep crease across the palm of the hand. They also tend to experience mild to moderate intellectual disabilities and developmental delays. Common health issues associated with Down syndrome include congenital heart defects, respiratory and hearing problems, and an increased risk of certain cancers.