This document outlines the history and development of infection control programs in hospitals. It discusses how modern programs began in the 1950s in England to control staphylococcal outbreaks. In the 1960s, the CDC began training courses in infection control and the JCAHO required hospitals to have infection control committees. The AIDS epidemic in the 1980s greatly challenged infection control professionals. The document proposes developing an infection control plan that assesses needs, formulates goals and objectives, evaluates programs, and ensures appropriate isolation of patients and antibiotic utilization to control infections in hospitals.