The document summarizes key points from the 2010 WHO guidelines for preventing mother-to-child transmission of HIV, treating pediatric HIV, and HIV treatment for adults and adolescents. Major changes included treating all HIV-positive pregnant women and children under 2, simplifying adult regimens, and emphasizing exclusive breastfeeding. Implementing these guidelines could virtually eliminate pediatric HIV but would require increased resources, integration, monitoring, and research to inform future revisions. The Elizabeth Glaser Pediatric AIDS Foundation aims to support countries in adapting and applying the guidelines through toolkits, advocacy, evaluation, and collaboration.