Dronedarone is a noniodinated benzofuran derivative that is similar to amiodarone in its electrophysiological effects. A clinical trial studied the effectiveness of dronedarone compared to placebo in maintaining sinus rhythm in patients with atrial fibrillation. The study found that dronedarone significantly reduced the risk of recurrence of atrial fibrillation compared to placebo and was associated with fewer adverse effects than amiodarone. However, longer term studies are still needed to fully evaluate dronedarone's safety profile.